Kaposi＆#39;s sarcoma （KS） is a rare,malignant vascular.tumor of the skin,mucosa,and viscera with an increased incidence in human immunodeficiency virus （HIV）-positive patients.According to the clinical characteri...Kaposi＆#39;s sarcoma （KS） is a rare,malignant vascular.tumor of the skin,mucosa,and viscera with an increased incidence in human immunodeficiency virus （HIV）-positive patients.According to the clinical characteristics and the affected population,four clinical types of KS have been described successively：classic,endemic to Africa,acquired immunodeficiency syndrome （AIDS）-associated,and immunosuppression associated type.Bullous pemphigoid （BP） is an acquired autoimmune bullous skin disease that frequently occurs in the elderly and is characterized by intraepidermal blisters and immunoglobulin G （IgG） deposits on the basement membrane.A few cases of KS have occurred in immunosuppressed patients with BP.Here,we report a Chinese female patient diagnosed with immunosuppression associated KS that was induced by the short-term use of immunosuppressive agents for BP.We also present a review of the literature on immunosuppressed KS with BP and discuss the potential role of human herpesvirus-8 （HHV-8） in the pathogenic mechanism.展开更多
富镁(Mg)次生黏土矿物是海底热液过程中水-岩反应的重要产物,广泛存在于全球的海底热液系统中,从而在海洋Mg循环中发挥着重要作用.然而,目前对Mg在该类型矿物中的富集程度和Mg的同位素分馏,特别是对产生在弧和弧后盆地中-高温(100~300℃...富镁(Mg)次生黏土矿物是海底热液过程中水-岩反应的重要产物,广泛存在于全球的海底热液系统中,从而在海洋Mg循环中发挥着重要作用.然而,目前对Mg在该类型矿物中的富集程度和Mg的同位素分馏,特别是对产生在弧和弧后盆地中-高温(100~300℃)热液系统的次生黏土矿物尚缺乏足够的认识.本研究以国际大洋钻探计划(IODP)331航次在冲绳海槽中部Iheya North Knoll热液区获得的富热液绿泥石沉积物、火山浮岩和陆源碎屑沉积物为研究对象,分析了其中的Mg含量和Mg同位素组成,并结合前期矿物学、主微量元素组成和Nd同位素组成的相关研究,系统探讨了绿泥石中Mg的来源和中-高温热液蚀变过程中Mg的同位素地球化学行为.研究表明,矿物学组成的差异决定了Mg同位素组成的变化,硅酸盐矿物的Mg同位素比值要高于碳酸盐和氧化物/氢氧化物的比值.Mg同位素在中-高温热液蚀变过程中发生显著分馏,其分馏程度(Δ^(26)Mg)在0.15~0.71‰,并与温度存在负相关关系.这进一步表明,较重的Mg同位素更容易被次生的绿泥石矿物所吸收.结合弧和弧后盆地在全球海洋中的分布范围,推断该构造类型中的热液系统是海洋Mg的重要汇,约占全球河流输入Mg通量的8~14%.虽然热液系统中绝大数的Mg被次生黏土矿物吸收,但仍然有少量的Mg残留在孔隙水和喷出的热液流体中.因为Mg同位素的分馏作用,较轻的Mg同位素留在了流体中,但该部分的通量尚需要更多的案例研究来澄清.展开更多
文摘Kaposi＆#39;s sarcoma （KS） is a rare,malignant vascular.tumor of the skin,mucosa,and viscera with an increased incidence in human immunodeficiency virus （HIV）-positive patients.According to the clinical characteristics and the affected population,four clinical types of KS have been described successively：classic,endemic to Africa,acquired immunodeficiency syndrome （AIDS）-associated,and immunosuppression associated type.Bullous pemphigoid （BP） is an acquired autoimmune bullous skin disease that frequently occurs in the elderly and is characterized by intraepidermal blisters and immunoglobulin G （IgG） deposits on the basement membrane.A few cases of KS have occurred in immunosuppressed patients with BP.Here,we report a Chinese female patient diagnosed with immunosuppression associated KS that was induced by the short-term use of immunosuppressive agents for BP.We also present a review of the literature on immunosuppressed KS with BP and discuss the potential role of human herpesvirus-8 （HHV-8） in the pathogenic mechanism.
文摘富镁(Mg)次生黏土矿物是海底热液过程中水-岩反应的重要产物,广泛存在于全球的海底热液系统中,从而在海洋Mg循环中发挥着重要作用.然而,目前对Mg在该类型矿物中的富集程度和Mg的同位素分馏,特别是对产生在弧和弧后盆地中-高温(100~300℃)热液系统的次生黏土矿物尚缺乏足够的认识.本研究以国际大洋钻探计划(IODP)331航次在冲绳海槽中部Iheya North Knoll热液区获得的富热液绿泥石沉积物、火山浮岩和陆源碎屑沉积物为研究对象,分析了其中的Mg含量和Mg同位素组成,并结合前期矿物学、主微量元素组成和Nd同位素组成的相关研究,系统探讨了绿泥石中Mg的来源和中-高温热液蚀变过程中Mg的同位素地球化学行为.研究表明,矿物学组成的差异决定了Mg同位素组成的变化,硅酸盐矿物的Mg同位素比值要高于碳酸盐和氧化物/氢氧化物的比值.Mg同位素在中-高温热液蚀变过程中发生显著分馏,其分馏程度(Δ^(26)Mg)在0.15~0.71‰,并与温度存在负相关关系.这进一步表明,较重的Mg同位素更容易被次生的绿泥石矿物所吸收.结合弧和弧后盆地在全球海洋中的分布范围,推断该构造类型中的热液系统是海洋Mg的重要汇,约占全球河流输入Mg通量的8~14%.虽然热液系统中绝大数的Mg被次生黏土矿物吸收,但仍然有少量的Mg残留在孔隙水和喷出的热液流体中.因为Mg同位素的分馏作用,较轻的Mg同位素留在了流体中,但该部分的通量尚需要更多的案例研究来澄清.
