Psoriasis is a kind of immune-mediated, chronic, inflammatory skin disease, which is often associated with different degrees of psychological disorders. Specifically, there is a significant correlation between psorias...Psoriasis is a kind of immune-mediated, chronic, inflammatory skin disease, which is often associated with different degrees of psychological disorders. Specifically, there is a significant correlation between psoriasis and depression, and they show the relationships of reciprocal causation and mutual promotion. Psoriasis with depression is more harmful than simple psoriasis, and its prognosis is worse, which brings a huge burden to the family and society and is worthy of clinical attention. Based on the pathogenic factors of western medicine and pathogenesis of traditional Chinese medicine in psoriasis with depression, the paper summarized and elaborated the research progress on the mechanism of traditional Chinese medicine in the treatment of psoriasis with depression, in order to provide new ideas for clinical treatment.展开更多
Objective:To observe the clinical efficacy,immune inflammatory factors and hemorheology of patients with plaque psoriasis by using fire acupuncture combined with the theory of midnight-noon ebb-flow.Methods:Sixty-two ...Objective:To observe the clinical efficacy,immune inflammatory factors and hemorheology of patients with plaque psoriasis by using fire acupuncture combined with the theory of midnight-noon ebb-flow.Methods:Sixty-two patients with plaque psoriasis who met the diagnosis and inclusion criteria were randomly divided into control group and fire acupuncture with midnight-noon ebb-flow,with 31 cases in each group.The control group was treated with carpotriol ointment for external use,while the fire acupuncture group was treated with fire acupuncture with midnight-noon ebb-flow on the basis of the former and selected points by the opening method through midnight-noon ebb-flow theory.The patients in both groups were treated for 8 weeks and followed up for 4 weeks.The levels of PASI,DLQI,PSQI,HAMA,hs-CRP,TNF-αand hemorheology indexes in 2 groups before and after treatment were observed,including the comparison of whole blood viscosity,plasma viscosity and hematocrit.Results:PASI,DLQI,PSQI,HAMA,hs-CRP,TNF-α,blood viscosity and hematocrit levels were significantly improved after treatment(P<0.05,P<0.01),and the group in fire acupuncture with midnight-noon ebb-flow was significantly better than control group after treatment(P<0.01).Conclusion:fire acupuncture with midnight-noon ebb-flow can improve the sleep quality of patients with psoriasis,relieve anxiety and effectively improve the blood cell rheology and microcirculation,alleviate clinical symptoms and improve the quality of life.展开更多
目的观察蜈蚣败毒饮对寻常型银屑病患者血脂代谢水平的影响并分析其相关性。方法将63例寻常型银屑病(血瘀证)患者随机分为治疗组33例及对照组30例。治疗组予蜈蚣败毒饮口服,对照组予郁金银屑片口服,比较两组治疗前后的银屑病面积与严重...目的观察蜈蚣败毒饮对寻常型银屑病患者血脂代谢水平的影响并分析其相关性。方法将63例寻常型银屑病(血瘀证)患者随机分为治疗组33例及对照组30例。治疗组予蜈蚣败毒饮口服,对照组予郁金银屑片口服,比较两组治疗前后的银屑病面积与严重性指数(psoriasis area and severity index,PASI)及血脂变化,采用相关分析对两组总胆固醇(total cholesterol,TC)、三酰甘油(triglyceride,TG)水平与PASI评分行相关性评价。结果两组PASI评分治疗后较本组治疗前均降低(P<0.05),组间比较显示,治疗后治疗组PASI评分低于对照组(P<0.05)。治疗组治疗前后高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)与低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)水平差异无统计学意义(P>0.05);治疗后较治疗前TC、TG水平降低(P<0.05),且△TC、△TG水平与△PASI评分均呈现出线性正相关性(P<0.05)。对照组治疗后与治疗前相比,TC、TG、HDL-C及LDL-C水平差异均无统计学意义(P>0.05),且△TC、△TG水平与△PASI评分无线性相关性(P>0.05)。结论蜈蚣败毒饮在临床上可有效调控银屑病患者血脂代谢水平,中医学病机可能与其解毒化瘀相关,本研究可进一步丰富中医药治疗银屑病的"毒"、"瘀"理论。展开更多
基金National Natural Science Foundation of China(No.81973846)Heilongjiang Province Traditional Chinese Medicine Research Fund Projec(No.t ZHY2022-132)。
文摘Psoriasis is a kind of immune-mediated, chronic, inflammatory skin disease, which is often associated with different degrees of psychological disorders. Specifically, there is a significant correlation between psoriasis and depression, and they show the relationships of reciprocal causation and mutual promotion. Psoriasis with depression is more harmful than simple psoriasis, and its prognosis is worse, which brings a huge burden to the family and society and is worthy of clinical attention. Based on the pathogenic factors of western medicine and pathogenesis of traditional Chinese medicine in psoriasis with depression, the paper summarized and elaborated the research progress on the mechanism of traditional Chinese medicine in the treatment of psoriasis with depression, in order to provide new ideas for clinical treatment.
基金This study was supported by National Natural Science Foundation of China(No.81973846)Natural Science Foundation of Heilongjiang Province(No.LH2019H108)Graduate Innovative Research Project of Heilongjiang University of Chinese Medicine(No.2020yjscx029)。
文摘Objective:To observe the clinical efficacy,immune inflammatory factors and hemorheology of patients with plaque psoriasis by using fire acupuncture combined with the theory of midnight-noon ebb-flow.Methods:Sixty-two patients with plaque psoriasis who met the diagnosis and inclusion criteria were randomly divided into control group and fire acupuncture with midnight-noon ebb-flow,with 31 cases in each group.The control group was treated with carpotriol ointment for external use,while the fire acupuncture group was treated with fire acupuncture with midnight-noon ebb-flow on the basis of the former and selected points by the opening method through midnight-noon ebb-flow theory.The patients in both groups were treated for 8 weeks and followed up for 4 weeks.The levels of PASI,DLQI,PSQI,HAMA,hs-CRP,TNF-αand hemorheology indexes in 2 groups before and after treatment were observed,including the comparison of whole blood viscosity,plasma viscosity and hematocrit.Results:PASI,DLQI,PSQI,HAMA,hs-CRP,TNF-α,blood viscosity and hematocrit levels were significantly improved after treatment(P<0.05,P<0.01),and the group in fire acupuncture with midnight-noon ebb-flow was significantly better than control group after treatment(P<0.01).Conclusion:fire acupuncture with midnight-noon ebb-flow can improve the sleep quality of patients with psoriasis,relieve anxiety and effectively improve the blood cell rheology and microcirculation,alleviate clinical symptoms and improve the quality of life.
文摘目的观察蜈蚣败毒饮对寻常型银屑病患者血脂代谢水平的影响并分析其相关性。方法将63例寻常型银屑病(血瘀证)患者随机分为治疗组33例及对照组30例。治疗组予蜈蚣败毒饮口服,对照组予郁金银屑片口服,比较两组治疗前后的银屑病面积与严重性指数(psoriasis area and severity index,PASI)及血脂变化,采用相关分析对两组总胆固醇(total cholesterol,TC)、三酰甘油(triglyceride,TG)水平与PASI评分行相关性评价。结果两组PASI评分治疗后较本组治疗前均降低(P<0.05),组间比较显示,治疗后治疗组PASI评分低于对照组(P<0.05)。治疗组治疗前后高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)与低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)水平差异无统计学意义(P>0.05);治疗后较治疗前TC、TG水平降低(P<0.05),且△TC、△TG水平与△PASI评分均呈现出线性正相关性(P<0.05)。对照组治疗后与治疗前相比,TC、TG、HDL-C及LDL-C水平差异均无统计学意义(P>0.05),且△TC、△TG水平与△PASI评分无线性相关性(P>0.05)。结论蜈蚣败毒饮在临床上可有效调控银屑病患者血脂代谢水平,中医学病机可能与其解毒化瘀相关,本研究可进一步丰富中医药治疗银屑病的"毒"、"瘀"理论。
