目的 探讨利拉鲁肽对糖尿病视网膜病变(DR)的临床疗效及机制。方法 前瞻性选取120例非增生型糖尿病视网膜病变(NPDR)患者,随机分为对照组和研究组。对照组采用常规治疗,研究组在对照组治疗的基础上使用利拉鲁肽0.6 mg/d皮下注射。分析两...目的 探讨利拉鲁肽对糖尿病视网膜病变(DR)的临床疗效及机制。方法 前瞻性选取120例非增生型糖尿病视网膜病变(NPDR)患者,随机分为对照组和研究组。对照组采用常规治疗,研究组在对照组治疗的基础上使用利拉鲁肽0.6 mg/d皮下注射。分析两组NPDR患者临床疗效、氧化应激指标及对胰高血糖素样肽-1(GLP-1)mRNA及内皮型一氧化氮(e-NOS)mRNA表达。采用非条件Logistic回归分析NPDR危险因素,采用Pearson相关性分析临床及氧化应激指标的相关性。结果 治疗后研究组总有效率高于对照组( P <0.05),而视野灰度值(VGV)低于对照组( P <0.05)。治疗后研究组体质量指数(BMI)、糖化血红蛋白(HbA1c)、甘油三酯(TG)、3-硝基酪氨酸(3-NT)低于对照组,空腹C肽(C-P)、一氧化氮(NO)、超氧化物歧化酶(SOD)、谷胱甘肽(GSH)高于对照组( P <0.05)。HbA1c、3-NT为NPDR的危险因素( P <0.05),NO、SOD、GSH、eNOS mRNA、GLP mRNA为NPDR的保护因素( P <0.05)。NO、SOD及GSH与TG、3-NT呈负相关,与GLP-1 mRNA及e-NOS mRNA呈正相关。结论 利拉鲁肽有明显治疗NPDR的效果,可能与利拉鲁肽抗氧化应激以及刺激GLP-eNOS/NO通路有关。展开更多
The complexity of underwater environment poses a challenge to underwater acoustic communication.In marine environment,different temperatures,depths and salinities would affect the performance of acoustic communication...The complexity of underwater environment poses a challenge to underwater acoustic communication.In marine environment,different temperatures,depths and salinities would affect the performance of acoustic communication.The analysis of the underwater acoustic channel under the influence of temperature factors provides a reference for further study of the underwater acoustic channel estimation problem based on filter bank multi-carrier(FBMC).The FBMC based offset quadrature amplitude modulation(OQAM)technology(FBMC/OQAM)was introduced into the underwater acoustic communication.Based on FBMC,the underwater acoustic channel estimation technology was studied.By changing the pilot structure to adapt to the complex and variable underwater acoustic channel,the iterative method was used to obtain the channel information with higher accuracy and further improve the performance of channel estimation.Theoretical analysis and simulation results show that iterative channel estimation algorithm based on the new interference approximation method(IAM)pilot proposed in this paper has better performance in underwater acoustic channel.展开更多
文摘目的 探讨利拉鲁肽对糖尿病视网膜病变(DR)的临床疗效及机制。方法 前瞻性选取120例非增生型糖尿病视网膜病变(NPDR)患者,随机分为对照组和研究组。对照组采用常规治疗,研究组在对照组治疗的基础上使用利拉鲁肽0.6 mg/d皮下注射。分析两组NPDR患者临床疗效、氧化应激指标及对胰高血糖素样肽-1(GLP-1)mRNA及内皮型一氧化氮(e-NOS)mRNA表达。采用非条件Logistic回归分析NPDR危险因素,采用Pearson相关性分析临床及氧化应激指标的相关性。结果 治疗后研究组总有效率高于对照组( P <0.05),而视野灰度值(VGV)低于对照组( P <0.05)。治疗后研究组体质量指数(BMI)、糖化血红蛋白(HbA1c)、甘油三酯(TG)、3-硝基酪氨酸(3-NT)低于对照组,空腹C肽(C-P)、一氧化氮(NO)、超氧化物歧化酶(SOD)、谷胱甘肽(GSH)高于对照组( P <0.05)。HbA1c、3-NT为NPDR的危险因素( P <0.05),NO、SOD、GSH、eNOS mRNA、GLP mRNA为NPDR的保护因素( P <0.05)。NO、SOD及GSH与TG、3-NT呈负相关,与GLP-1 mRNA及e-NOS mRNA呈正相关。结论 利拉鲁肽有明显治疗NPDR的效果,可能与利拉鲁肽抗氧化应激以及刺激GLP-eNOS/NO通路有关。
基金Focus on Research and Development Plan in Shandong Province(Special Public Welfare Project)(No.2018GHY115022)National Natural Science Foundation of China(No.61471224)。
文摘The complexity of underwater environment poses a challenge to underwater acoustic communication.In marine environment,different temperatures,depths and salinities would affect the performance of acoustic communication.The analysis of the underwater acoustic channel under the influence of temperature factors provides a reference for further study of the underwater acoustic channel estimation problem based on filter bank multi-carrier(FBMC).The FBMC based offset quadrature amplitude modulation(OQAM)technology(FBMC/OQAM)was introduced into the underwater acoustic communication.Based on FBMC,the underwater acoustic channel estimation technology was studied.By changing the pilot structure to adapt to the complex and variable underwater acoustic channel,the iterative method was used to obtain the channel information with higher accuracy and further improve the performance of channel estimation.Theoretical analysis and simulation results show that iterative channel estimation algorithm based on the new interference approximation method(IAM)pilot proposed in this paper has better performance in underwater acoustic channel.
