本文主要是对在线问诊中产生的医疗文本进行命名实体识别的研究.使用在线医疗问答网站的数据,采用{B, I, O}标注体系构建数据集,抽取疾病、治疗、检查和症状四个医疗实体.以BiLSTM-CRF为基准模型,提出两种深度学习模型IndRNN-CRF和IDCNN...本文主要是对在线问诊中产生的医疗文本进行命名实体识别的研究.使用在线医疗问答网站的数据,采用{B, I, O}标注体系构建数据集,抽取疾病、治疗、检查和症状四个医疗实体.以BiLSTM-CRF为基准模型,提出两种深度学习模型IndRNN-CRF和IDCNN-BiLSTM-CRF,并在自构建数据集上验证模型的有效性.将新提出的两种模型与基准模型通过实验对比得出:模型IDCNN-BiLSTM-CRF的F1值0.8116,超过了BiLSTM-CRF的F1值0.8009, IDCNN-BiLSTM-CRF整体性能好于BiLSTM-CRF模型;模型IndRNN-CRF的精确率0.8427,但该模型在召回率上低于基准模型BiLSTM-CRF.展开更多
Objective:To explore and verify the mechanism of Gan Dou Ling in improving liver fibrosis in Wilson disease(WD)by network pharmacology and copper loaded mice experiments.Methods:The main chemical components and corres...Objective:To explore and verify the mechanism of Gan Dou Ling in improving liver fibrosis in Wilson disease(WD)by network pharmacology and copper loaded mice experiments.Methods:The main chemical components and corresponding gene targets of each drug in Gan Dou Ling were obtained by using TCMSP database.The database of gene mutation and disease related gene was searched through the GeneCards database,DrugBank database,PharmGKB database and the DisGeNET database.After the intersection of drug and disease target genes.The STRING website was used to analyze the protein-protein interaction degree of target genes,and import the data to Cytoscape software 38.2 to analyze protein interaction network.The GO databases and KEGG databases were obtained in R language for enrichment analysis.On this basis,Masson staining were used to observe the degree of liver fibrosis in copper loaded mouse model,and the results of network pharmacological analysis were verified by Western Blot(WB).Results:A total of 108 drug disease intersection genes were analyzed by network pharmacology.Through PPI network analysis,JUN was found to be the key genes.The enrichment analysis of KEGG pathway showed that MAPK signal pathway was the important potential target pathways.Animal experiments showed that Gan Dou Ling could reduce liver fibrosis and inhibit the phosphorylation of P38,JNK and C-JUN in copper loaded mice.Conclusion:Gan Dou Ling may achieve the effect of treating WD liver fibrosis by inhibiting P38/JNK signaling pathway.展开更多
文摘本文主要是对在线问诊中产生的医疗文本进行命名实体识别的研究.使用在线医疗问答网站的数据,采用{B, I, O}标注体系构建数据集,抽取疾病、治疗、检查和症状四个医疗实体.以BiLSTM-CRF为基准模型,提出两种深度学习模型IndRNN-CRF和IDCNN-BiLSTM-CRF,并在自构建数据集上验证模型的有效性.将新提出的两种模型与基准模型通过实验对比得出:模型IDCNN-BiLSTM-CRF的F1值0.8116,超过了BiLSTM-CRF的F1值0.8009, IDCNN-BiLSTM-CRF整体性能好于BiLSTM-CRF模型;模型IndRNN-CRF的精确率0.8427,但该模型在召回率上低于基准模型BiLSTM-CRF.
基金supported by the National Natural Science Foundation of China(No.81973825)the Natural Science Research Foundation of Anhui Province Universities(No.KJ2020A0436)。
文摘Objective:To explore and verify the mechanism of Gan Dou Ling in improving liver fibrosis in Wilson disease(WD)by network pharmacology and copper loaded mice experiments.Methods:The main chemical components and corresponding gene targets of each drug in Gan Dou Ling were obtained by using TCMSP database.The database of gene mutation and disease related gene was searched through the GeneCards database,DrugBank database,PharmGKB database and the DisGeNET database.After the intersection of drug and disease target genes.The STRING website was used to analyze the protein-protein interaction degree of target genes,and import the data to Cytoscape software 38.2 to analyze protein interaction network.The GO databases and KEGG databases were obtained in R language for enrichment analysis.On this basis,Masson staining were used to observe the degree of liver fibrosis in copper loaded mouse model,and the results of network pharmacological analysis were verified by Western Blot(WB).Results:A total of 108 drug disease intersection genes were analyzed by network pharmacology.Through PPI network analysis,JUN was found to be the key genes.The enrichment analysis of KEGG pathway showed that MAPK signal pathway was the important potential target pathways.Animal experiments showed that Gan Dou Ling could reduce liver fibrosis and inhibit the phosphorylation of P38,JNK and C-JUN in copper loaded mice.Conclusion:Gan Dou Ling may achieve the effect of treating WD liver fibrosis by inhibiting P38/JNK signaling pathway.
