Prolactinoma is an estrogen-related tumor and leukemia-related protein 16 （LRP16） is correlated with the progression of estrogen-related tumors, but the regulatory mechanism between LRP16 and prolactinoma remain unc...Prolactinoma is an estrogen-related tumor and leukemia-related protein 16 （LRP16） is correlated with the progression of estrogen-related tumors, but the regulatory mechanism between LRP16 and prolactinoma remain unclear. This study demonstrates a variation in LRP16 with estrogen receptor a （ERa） in prolactinoma models and the up and downregulation effects of LRP16 on prolactin secretion of pituitary adenomas cells （GH3 cells）. In our study, 50 male SD rats （30-day-old） were randomly divided into five groups of 10 rats each. After 120 days of treatment,展开更多
基金financially supported by the National Natural Science Foundation of China and Hainan Province.[NSFC,Grant Nos.81570705 and 81270866NSFH,Grant No.20168353]
文摘Prolactinoma is an estrogen-related tumor and leukemia-related protein 16 （LRP16） is correlated with the progression of estrogen-related tumors, but the regulatory mechanism between LRP16 and prolactinoma remain unclear. This study demonstrates a variation in LRP16 with estrogen receptor a （ERa） in prolactinoma models and the up and downregulation effects of LRP16 on prolactin secretion of pituitary adenomas cells （GH3 cells）. In our study, 50 male SD rats （30-day-old） were randomly divided into five groups of 10 rats each. After 120 days of treatment,
