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食管鳞状细胞癌肿瘤细胞和间质细胞中podoplanin的表达及临床意义 被引量:1
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作者 田华 杨永国 梅霞 《临床与实验病理学杂志》 CAS CSCD 北大核心 2020年第5期547-551,共5页
目的探讨食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)中podoplanin在肿瘤细胞和间质细胞的表达及其临床意义。方法应用免疫组化EnVision法检测150例ESCC中podoplanin的表达,分析肿瘤细胞、间质细胞中podoplanin表达以及... 目的探讨食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)中podoplanin在肿瘤细胞和间质细胞的表达及其临床意义。方法应用免疫组化EnVision法检测150例ESCC中podoplanin的表达,分析肿瘤细胞、间质细胞中podoplanin表达以及两者共表达与临床病理特征之间的关系。结果150例ESCC中,肿瘤细胞podoplanin阳性者50例,其表达与淋巴结转移、脉管侵犯和TNM分期呈正相关(P<0.05);与患者性别、年龄、肿瘤大小、组织学分级、浸润深度和神经侵犯均无关(P>0.05)。podoplanin在间质细胞中的阳性率为54%(81/150),其表达与浸润深度、淋巴结转移、脉管侵犯和TNM分期均有关(P<0.05);与患者性别、年龄、肿瘤大小、组织学分级及神经侵犯无关(P>0.05)。ESCC肿瘤细胞和间质细胞中podoplanin共阳性者44例,肿瘤细胞和间质细胞中podoplanin共阳性与淋巴结转移、脉管侵犯、神经侵犯和TNM分期密切相关(P<0.05)。相关分析显示肿瘤细胞和间质细胞中podoplanin表达呈正相关(P<0.05)。结论ESCC肿瘤细胞和间质细胞中podoplanin表达可促进食管癌的发展,肿瘤细胞podoplanin表达可能诱导间质细胞表达podoplanin,两者协调促进ESCC的发生。 展开更多
关键词 食管肿瘤 肿瘤细胞 间质细胞 PODOPLANIN 免疫组织化学
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肺多发性梭形细胞非典型类癌1例报道
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作者 李小玲 杨永国 +1 位作者 田华 潘敏鸿 《诊断病理学杂志》 2021年第9期766-768,共3页
肺神经内分泌肿瘤包括小细胞癌、大细胞神经内分泌癌、类癌和弥漫性特发性肺神经内分泌细胞增生[1]。其中小细胞癌、大细胞神经内分泌癌均可与其他类型癌混合,称为复合性小细胞癌、大细胞神经内分泌癌,类癌包括典型和非典型类癌,占所有... 肺神经内分泌肿瘤包括小细胞癌、大细胞神经内分泌癌、类癌和弥漫性特发性肺神经内分泌细胞增生[1]。其中小细胞癌、大细胞神经内分泌癌均可与其他类型癌混合,称为复合性小细胞癌、大细胞神经内分泌癌,类癌包括典型和非典型类癌,占所有肺恶性肿瘤1%~2%,主要发生于支气管周围和肺门部[2-3]。发生于肺部周围较为少见,肿瘤为多发性且呈梭形细胞形态者更为罕见。 展开更多
关键词 肺肿瘤 非典型类癌 梭形细胞 多发性
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Mineral resource analysis by parabolic fractals 被引量:6
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作者 XIE Shu-yun yang yong-guo +2 位作者 BAO Zheng-yu KE Xian-zhong LILT Xiao-long 《Mining Science and Technology》 EI CAS 2009年第1期91-96,共6页
Elemental concentration distributions in space have been analyzed using different approaches. These analyses are of great significance for the quantitative characterization of various kinds of distribution patterns. F... Elemental concentration distributions in space have been analyzed using different approaches. These analyses are of great significance for the quantitative characterization of various kinds of distribution patterns. Fractal and multi-fractal methods have been extensively applied to this topic. Traditionally, approximately linear-fractal laws have been regarded as useful tools for characterizing the self-similarities of element concentrations. But, in nature, it is not always easy to find perfect linear fractal laws. In this paper the parabolic fractal model is used. First a two dimensional multiplicative multi-fractal cascade model is used to study the concentration patterns. The results show the parabolic fractal (PF) properties of the concentrations and the validity of non-linear fractal analysis. By dividing the studied area into four sub-areas it was possible to show that each part follows a non-linear parabolic fractal law and that the dispersion within each part varies. The ratio of the polynomial coefficients of the fitted parabolic curves can reflect, to some degree, the relative concentration and dispersal distribution patterns. This can provide new insight into the ore-forming potential in space. The parabofic fractal evaluations of ore-forming potential for the four suhareas are in good agreement with field investigation work and geochemical mapping results based on analysis of the original data. 展开更多
关键词 parabolic fractal multiplicative multifractal cascade modeling ore-forming potential geochemical mapping
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