目的:分析重症监护病房(Intensive Care Unit,ICU)念珠菌血流感染的病原菌分布、患者的临床特点及死亡的危险因素。方法:采用回顾性分析法,收集中南大学湘雅医院2016年1月至2020年12月ICU念珠菌血流感染患者的临床资料、感染相关指标及...目的:分析重症监护病房(Intensive Care Unit,ICU)念珠菌血流感染的病原菌分布、患者的临床特点及死亡的危险因素。方法:采用回顾性分析法,收集中南大学湘雅医院2016年1月至2020年12月ICU念珠菌血流感染患者的临床资料、感染相关指标及预后情况,分析念珠菌血流感染病原菌分布及患者的临床特点,并根据预后将患者分为死亡组和生存组,采用单因素分析及多因素logistic回归分析其死亡的危险因素。结果:在80例血流念珠菌感染患者中,白念珠菌感染率(36.3%)最高。药敏结果表明各种念珠菌对两性霉素B均为野生型,相对敏感。白念珠菌对氟康唑、伊曲康唑、伏立康唑相对敏感(均≥96.6%),非白念珠菌对氟康唑、伊曲康唑、伏立康唑有一定程度的耐药。80例患者中29例(36.3%)死亡。单因素分析显示急性生理学和慢性健康状况评价Ⅱ(acute physiology and chronic health evaluation Ⅱ,APACHEⅡ)评分≥20、糖尿病及机械通气与念珠菌血流感染患者死亡相关。Logistic回归分析提示APACHE Ⅱ评分≥20是念珠菌血流感染患者死亡的独立危险因素(OR=0.220,95%CI:0.078~0.619,P=0.004)。结论:白念珠菌是ICU患者念珠菌血流感染最常见的菌种。APACHE Ⅱ评分≥20是念珠菌血流感染患者死亡的独立危险因素。展开更多
The aerodynamic model of propeller,wing,fuselage and vertical tail are established for the tilt quad rotor(TQR)with partial tilt-wing,and then the flight dynamic model is established.Based on the six-degree-of-freedom...The aerodynamic model of propeller,wing,fuselage and vertical tail are established for the tilt quad rotor(TQR)with partial tilt-wing,and then the flight dynamic model is established.Based on the six-degree-of-freedom equation and the small disturbance linearization assumption,the trimming and stability of the tilt quad rotor with partial tilt-wing and the tilt quad rotor without tilt-wing are analyzed.The results show that in the hovering state,due to the existence of tilt-wing,the propeller wake reduces the downwash on the wing,thereby reducing the vertical weight gain of the aircraft.It is beneficial to increase the endurance time and improve the endurance performance.The transition corridor of the TQR with tilt-wing is narrower than that of the TQR without tilt-wing,but the transition corridor of TQR with tilt-wing still has a large space for design.Furthermore,the stability analysis shows that the Dutch roll damping ratio is larger,and in other modes the aircraft has a certain stability.The manipulation response analysis shows that in the transition mode the lateral-directional coupling is strong.展开更多
文摘目的:分析重症监护病房(Intensive Care Unit,ICU)念珠菌血流感染的病原菌分布、患者的临床特点及死亡的危险因素。方法:采用回顾性分析法,收集中南大学湘雅医院2016年1月至2020年12月ICU念珠菌血流感染患者的临床资料、感染相关指标及预后情况,分析念珠菌血流感染病原菌分布及患者的临床特点,并根据预后将患者分为死亡组和生存组,采用单因素分析及多因素logistic回归分析其死亡的危险因素。结果:在80例血流念珠菌感染患者中,白念珠菌感染率(36.3%)最高。药敏结果表明各种念珠菌对两性霉素B均为野生型,相对敏感。白念珠菌对氟康唑、伊曲康唑、伏立康唑相对敏感(均≥96.6%),非白念珠菌对氟康唑、伊曲康唑、伏立康唑有一定程度的耐药。80例患者中29例(36.3%)死亡。单因素分析显示急性生理学和慢性健康状况评价Ⅱ(acute physiology and chronic health evaluation Ⅱ,APACHEⅡ)评分≥20、糖尿病及机械通气与念珠菌血流感染患者死亡相关。Logistic回归分析提示APACHE Ⅱ评分≥20是念珠菌血流感染患者死亡的独立危险因素(OR=0.220,95%CI:0.078~0.619,P=0.004)。结论:白念珠菌是ICU患者念珠菌血流感染最常见的菌种。APACHE Ⅱ评分≥20是念珠菌血流感染患者死亡的独立危险因素。
基金supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
文摘The aerodynamic model of propeller,wing,fuselage and vertical tail are established for the tilt quad rotor(TQR)with partial tilt-wing,and then the flight dynamic model is established.Based on the six-degree-of-freedom equation and the small disturbance linearization assumption,the trimming and stability of the tilt quad rotor with partial tilt-wing and the tilt quad rotor without tilt-wing are analyzed.The results show that in the hovering state,due to the existence of tilt-wing,the propeller wake reduces the downwash on the wing,thereby reducing the vertical weight gain of the aircraft.It is beneficial to increase the endurance time and improve the endurance performance.The transition corridor of the TQR with tilt-wing is narrower than that of the TQR without tilt-wing,but the transition corridor of TQR with tilt-wing still has a large space for design.Furthermore,the stability analysis shows that the Dutch roll damping ratio is larger,and in other modes the aircraft has a certain stability.The manipulation response analysis shows that in the transition mode the lateral-directional coupling is strong.
