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基于LC-MS技术的急性冠脉综合征代谢组学研究 被引量:2
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作者 俞鹏 杨哲君 +3 位作者 石瑞洁 孙伟新 陈晓虎 沈乐 《海南医学院学报》 CAS 2022年第22期1694-1703,共10页
目的:观察不稳定型心绞痛(UA)与急性心肌梗死(AMI)患者的血浆代谢组分,筛选潜在的差异性标志物,探讨可能的生物学机制,为急性冠脉综合征的早期评估提供参考。方法:收集UA和AMI患者的血浆样本,获取一般信息,运用液质联用技术检测代谢物... 目的:观察不稳定型心绞痛(UA)与急性心肌梗死(AMI)患者的血浆代谢组分,筛选潜在的差异性标志物,探讨可能的生物学机制,为急性冠脉综合征的早期评估提供参考。方法:收集UA和AMI患者的血浆样本,获取一般信息,运用液质联用技术检测代谢物。通过偏最小二乘判别分析、正交化偏最小二乘判别分析模型,并结合单变量统计分析,进一步确定显著差异代谢物及其通路。结果:共纳入UA组33例、AMI组47例样本进行检测,发现UA与AMI的显著差异代谢物54种,代谢通路共20条。泮托拉唑、乙酰左旋肉碱、棕榈酰乙醇酰胺、甜菜碱、辛酸、胆红素、组氨酸、油酸、枸橼酸盐、香草醛等代谢物可作为鉴别二者的潜在生物标志物,其涉及的通路包括ABC转运蛋白、氨酰-tRNA生物合成、癌症的中心碳代谢等。结论:UA与AMI的血浆代谢组分存在显著差异,代谢组学相关研究对探求其生物学本质具有一定指导意义。 展开更多
关键词 急性冠脉综合征 不稳定型心绞痛 急性心肌梗死 代谢组学 差异代谢物
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Study on metabonomics in patients with acute coronary syndrome based on LC-MS technology
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作者 YU Peng yang zhe-jun +3 位作者 SHI Rui-jie SUN Wei-xin CHEN Xiao-hu SHEN Le 《Journal of Hainan Medical University》 2022年第22期15-23,共9页
Objective:To investigate the plasma metabolic components of patients with unstable angina(UA)and acute myocardial infarction(AMI),and to screen potential biomarkers and explore possible biological mechanisms in order ... Objective:To investigate the plasma metabolic components of patients with unstable angina(UA)and acute myocardial infarction(AMI),and to screen potential biomarkers and explore possible biological mechanisms in order to provide reference for early evaluation of acute coronary syndrome.Methods:Plasma samples from patients with UA and AMI were collected to obtain their general information,and the metabolites were detected by LCMS technology.Combined with univariate statistical analysis,the significantly different metabolites and their pathways were further determined by partial least squares discriminant analysis and orthogonalized partial least squares discriminant analysis models.Results:A total of 33 samples from UA group and 47 samples from AMI group were included for testing.Then 54 metabolites and 20 pathways were found to be significantly different between them.Metabolites such as pantoprazole,acetylcarnitine,palmitoyl ethanolamide,betaine,caprylic acid,bilirubin,histidine,oleic acid,citrate,vanillin can be used as potential biomarkers to distinguish them.The pathways include ABC transporters,aminoacyl-tRNA biosynthesis,central carbon metabolism in cancer and so on.Conclusion:There are significant differences in the plasma metabolic components of UA and AMI.Studies related to metabolomics may guide significance for exploring the biological nature of ACS. 展开更多
关键词 Acute coronary syndrome Unstable angina Acute myocardial infarction Metabolomics Differential metabolites
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