The effects of exercise interventions on brain-derived neurotrophic factor levels in children and adolescents:a meta-analysis

Brain-derived neurotrophic factor is a crucial neurotrophic factor that plays a significant role in brain health. Although the vast majority of meta-analyses have confirmed that exercise interventions can increase brain-derived neurotrophic factor levels in children and adolescents, the effects of specific types of exercise on brain-derived neurotrophic factor levels are still controversial. To address this issue, we used meta-analytic methods to quantitatively evaluate, analyze, and integrate relevant studies. Our goals were to formulate general conclusions regarding the use of exercise interventions, explore the physiological mechanisms by which exercise improves brain health and cognitive ability in children and adolescents, and provide a reliable foundation for follow-up research. We used the Pub Med, Web of Science, Science Direct, Springer, Wiley Online Library, Weipu, Wanfang, and China National Knowledge Infrastructure databases to search for randomized controlled trials examining the influences of exercise interventions on brain-derived neurotrophic factor levels in children and adolescents. The extracted data were analyzed using Review Manager 5.3. According to the inclusion criteria, we assessed randomized controlled trials in which the samples were mainly children and adolescents, and the outcome indicators were measured before and after the intervention. We excluded animal experiments, studies that lacked a control group, and those that did not report quantitative results. The mean difference(MD;before versus after intervention) was used to evaluate the effect of exercise on brain-derived neurotrophic factor levels in children and adolescents. Overall, 531 participants(60 children and 471 adolescents, 10.9–16.1 years) were included from 13 randomized controlled trials. Heterogeneity was evaluated using the Q statistic and I^(2) test provided by Review Manager software. The meta-analysis showed that there was no heterogeneity among the studies(P = 0.67, I^(2) = 0.00%). The combined effect of the interventions was significant(MD = 2.88, 95% CI: 1.53–4.22, P < 0.0001), indicating that the brain-derived neurotrophic factor levels of the children and adolescents in the exercise group were significantly higher than those in the control group. In conclusion, different types of exercise interventions significantly increased brain-derived neurotrophic factor levels in children and adolescents. However, because of the small sample size of this meta-analysis, more high-quality research is needed to verify our conclusions. This metaanalysis was registered at PROSPERO(registration ID: CRD42023439408).

Covalent Organic Framework with 3D Ordered Channel and Multi-Functional Groups Endows Zn Anode with Superior Stability

Achieving a highly robust zinc(Zn)metal anode is extremely important for improving the performance of aqueous Zn-ion batteries(AZIBs)for advancing“carbon neutrality”society,which is hampered by the uncontrollable growth of Zn dendrite and severe side reactions including hydrogen evolution reaction,corrosion,and passivation,etc.Herein,an interlayer containing fluorinated zincophilic covalent organic framework with sulfonic acid groups(COF-S-F)is developed on Zn metal(Zn@COF-S-F)as the artificial solid electrolyte interface(SEI).Sulfonic acid group(-SO_(3)H)in COF-S-F can effectively ameliorate the desolvation process of hydrated Zn ions,and the three-dimensional channel with fluoride group(-F)can provide interconnected channels for the favorable transport of Zn ions with ion-confinement effects,endowing Zn@COF-S-F with dendrite-free morphology and suppressed side reactions.Consequently,Zn@COF-S-F symmetric cell can stably cycle for 1,000 h with low average hysteresis voltage(50.5 m V)at the current density of 1.5 m A cm^(-2).Zn@COF-S-F|Mn O_(2)cell delivers the discharge specific capacity of 206.8 m Ah g^(-1)at the current density of 1.2 A g^(-1)after 800 cycles with high-capacity retention(87.9%).Enlightening,building artificial SEI on metallic Zn surface with targeted design has been proved as the effective strategy to foster the practical application of high-performance AZIBs.

Viability of all-solid-state lithium metal battery coupled with oxide solid-state electrolyte and high-capacity cathode

Owing to the utilization of lithium metal as anode with the ultrahigh theoretical capacity density of 3860 mA h g^(-1)and oxide-based ceramic solid-state electrolytes(SE),e.g.,garnet-type Li7La_(3)Zr_(2)O_(12)(LLZO),all-state-state lithium metal batteries(ASLMBs)have been widely accepted as the promising alternatives for providing the satisfactory energy density and safety.However,its applications are still challenged by plenty of technical and scientific issues.In this contribution,the co-sintering temperature at 500℃is proved as a compromise method to fabricate the composite cathode with structural integrity and declined capacity fading of LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2)(NCM).On the other hand,it tends to form weaker grain boundary(GB)inside polycrystalline LLZO at inadequate sintering temperature for LLZO,which can induce the intergranular failure of SE during the growth of Li filament inside the unavoidable defect on the interface of SE.Therefore,increasing the strength of GB,refining the grain to 0.4μm,and precluding the interfacial defect are suggested to postpone the electro-chemo-mechanical failure of SE with weak GB.Moreover,the advanced sintering techniques to lower the co-sintering temperature for both NCM-LLZO composite cathode and LLZO SE can be posted out to realize the viability of state-of-the-art ASLMBs with higher energy density as well as the guaranteed safety.

The wheat sucrose synthase gene TaSus1 is a determinant of grain number per spike

Some haplotypes of the sucrose synthase gene TaSus1 are associated with thousand-grain weight(TGW)in wheat(Triticum aestivum L.).However,no mutations have been identified within the gene to test this association.The effects of TaSus1 on grain number per spike(GNS)also are largely unknown.Our previous genome-wide association study identified TaSus-A1 as a candidate gene controlling fertile spikelet number per spike(FSN).In the present study,we generated two independent mutants for the three TaSus1 homoeologs by CRISPR/Cas9-mediated genome editing.The triple mutants displayed lower FSN,GNS,grain number per spikelet(GNST),and TGW than wild-type plants.In 306 hexaploid wheat accessions,two single-nucleotide polymorphisms in TaSus-A1 contributed differently to GNS.Introgression of the two alleles into a wheat genetic background confirmed their effects.The alleles differed in geographical distribution among the accessions.

Selection of Negative Charged Acidic Polar Additives to Regulate Electric Double Layer for Stable Zinc Ion Battery

Zinc-ion batteries are promising for large-scale electrochemical energy storage systems,which still suffer from interfacial issues,e.g.,hydrogen evolution side reaction(HER),self-corrosion,and uncontrollable dendritic Zn electrodeposition.Although the regulation of electric double layer(EDL)has been verified for interfacial issues,the principle to select the additive as the regulator is still misted.Here,several typical amino acids with different characteristics were examined to reveal the interfacial behaviors in regulated EDL on the Zn anode.Negative charged acidic polarity(NCAP)has been unveiled as the guideline for selecting additive to reconstruct EDL with an inner zincophilic H_(2)O-poor layer and to replace H_(2)O molecules of hydrated Zn^(2+)with NCAP glutamate.Taking the synergistic effects of EDL regulation,the uncontrollable interface is significantly stabilized from the suppressed HER and anti-self-corrosion with uniform electrodeposition.Consequently,by adding NCAP glutamate,a high average Coulombic efficiency of 99.83%of Zn metal is achieved in Zn|Cu asymmetrical cell for over 2000 cycles,and NH4V4O10|Zn full cell exhibits a high-capacity retention of 82.1%after 3000 cycles at 2 A g^(-1).Recapitulating,the NCAP principle posted here can quicken the design of trailblazing electrolyte additives for aqueous Zn-based electrochemical energy storage systems.

基于光声技术的椎弓根螺钉穿刺路径上骨组织特性研究

在脊柱内固定术中,实现PS的准确植入是一个难题。该文基于光声技术研究PS穿刺路径上骨组织的差异,将为光声技术的术中应用提供一个重要的支撑。具体地,分析研究骨组织的光学特性差异,然后研究骨膜、骨松质、骨密质对于特定光的光声参数差异。研究表明,基于光声技术可以实现不同骨组织的区分。

Improved GNSS Cooperation Positioning Algorithm for Indoor Localization

For situations such as indoor and underground parking lots in which satellite signals are obstructed,GNSS cooperative positioning can be used to achieve highprecision positioning with the assistance of cooperative nodes.Here we study the cooperative positioning of two static nodes,node 1 is placed on the roof of the building and the satellite observation is ideal,node 2 is placed on the indoor windowsill where the occlusion situation is more serious,we mainly study how to locate node 2 with the assistance of node 1.Firstly,the two cooperative nodes are located with pseudo-range single point positioning,and the positioning performance of cooperative node is analyzed,therefore the information of pseudo-range and position of node 1 is obtained.Secondly,the distance between cooperative nodes is obtained by using the baseline method with double-difference carrier phase.Finally,the cooperative location algorithms are studied.The Extended Kalman Filtering(EKF),Unscented Kalman Filtering(UKF)and Particle Filtering(PF)are used to fuse the pseudo-range,ranging information and location information respectively.Due to the mutual influences among the cooperative nodes in cooperative positioning,the EKF,UKF and PF algorithms are improved by resetting the error covariance matrix of the cooperative nodes at each update time.Experimental results show that after being improved,the influence between the cooperative nodes becomes smaller,and the positioning performance of the nodes is better than before.

First-principles study on the mechanical properties and thermodynamic properties of Mo-Ta alloys

The mechanical properties,thermodynamic properties and electronic structure of Mo1-xTax(Mo-Ta)alloys(x=0,0.0625,0.125,0.25,0.3125,0.5 and 1)were calculated by using firstprinciples.The electronic structure of Mo-Ta alloys was analysed by the projected density of states(PDOS).The low temperature heat capacity was estimated by Fermi energy and Debye temperature.It is shown that the formation enthalpy will decrease with the increase of Ta content,and the cohesive energy will increase with the increase of the Ta content.On the other hand,the addition of Ta atoms will reduce the strength and improve the ductility of Mo-Ta alloys,the Debye temperature will decrease and the low temperature heat capacity will be improved with the increase of the Ta content.All these results will be useful for the research of new plasma grid(PG)materials,which is mainly used in neutral beam injection(NBI)systems to produce negative hydrogen ions.

Statistical properties of kinetic-scale magnetic holes in terrestrial space

Kinetic-scale magnetic holes(KSMHs)are structures characterized by a significant magnetic depression with a length scale on the order of the proton gyroradius.These structures have been investigated in recent studies in near-Earth space,and found to be closely related to energy conversion and particle acceleration,wave-particle interactions,magnetic reconnection,and turbulence at the kineticscale.However,there are still several major issues of the KSMHs that need further study—including(a)the source of these structures(locally generated in near-Earth space,or carried by the solar wind),(b)the environmental conditions leading to their generation,and(c)their spatio-temporal characteristics.In this study,KSMHs in near-Earth space are investigated statistically using data from the Magnetospheric Multiscale mission.Approximately 200,000 events were observed from September 2015 to March 2020.Occurrence rates of such structures in the solar wind,magnetosheath,and magnetotail were obtained.We find that KSMHs occur in the magnetosheath at rates far above their occurrence in the solar wind.This indicates that most of the structures are generated locally in the magnetosheath,rather than advected with the solar wind.Moreover,KSMHs occur in the downstream region of the quasi-parallel shock at rates significantly higher than in the downstream region of the quasi-perpendicular shock,indicating a relationship with the turbulent plasma environment.Close to the magnetopause,we find that the depths of KSMHs decrease as their temporal-scale increases.We also find that the spatial-scales of the KSMHs near the subsolar magnetosheath are smaller than those in the flanks.Furthermore,their global distribution shows a significant dawn-dusk asymmetry(duskside dominating)in the magnetotail.

Error Probability Analysis for Ultra-Massive MIMO System and Near-Optimal Signal Detection

In this paper,average bit error probability(ABEP)bound of optimal maximum likelihood(ML)detector is first derived for ultra massive(UM)multiple-input-multiple-output(MIMO)system with generalized amplitude phase modulation(APM),which is confirmed by simulation results.Furthermore,a minimum residual criterion(MRC)based lowcomplexity near-optimal ML detector is proposed for UM-MIMO system.Specifically,we first obtain an initial estimated signal by a conventional detector,i.e.,matched filter(MF),or minimum mean square error(MMSE)and so on.Furthermore,MRC based error correction mechanism(ECM)is proposed to correct the erroneous symbol encountered in the initial result.Simulation results are shown that the performance of the proposed MRC-ECM based detector is capable of approaching theoretical ABEP of ML,despite only imposing a slightly higher complexity than that of the initial detector.

A real-time artifact reduction algorithm based on precise threshold during short-separation optical probe insertion in neurosurgery

During neurosurgery,an optical probe has been used to guide the micro-electrode,which is punc-tured into the globus pallidus(GP)to create a lesion that can relieve the cardinal symptoms.Accurate target localization is the key factor to afect the treatment.However,considering the scattering nature of the tissue,the“look ahead distance(LAD)”of optical probe makes the boundary between the diferent tissues blurred and difficult to be distinguished,which is defined as artifact.Thus,it is highly desirable to reduce the artifact caused by LAD.In this paper,a real-time algorithm based on precise threshold was proposed to eliminate the artifact.The value of the threshold was determined by the maximum error of the measurement system during the calibration procession automatically.Then,the measured data was processed sequentially only based on the threshold and the former data.Moreover,100μm double-fiber probe and two-layer and multi-layer phantom models were utilized to validate the precision of the algorithm.The error of the algorithm is one puncture step,which was proved in the theory and experiment.It was concluded that the present method could reduce the artifact caused by LAD and make the real boundary sharper and less blurred in real-time.It might be potentially used for the neurosurgery navigation.

Investigation of optical reflectance from different animal vertebra along the fixation trajectory of pedicle screw in frequency domain

Accurate placement of pedicle screw(PS)is crucial in spinal surgery.Developing new real-time intra-operative monitoring and navigation methods is an important direction of clinical appli-cation research.In this paper,we studied the spectrum along the fixation trajectory of PS in frequency domain to tackle the accuracy problem.Fresh porcine vertebrae,bovine vertebrae and ovine vertebrae were measured with the near-infrared spectrum(NIR)device to obtain the reflected spectrum from the vertebrae.Along the fixation trajectory of PS,average energy from different groups was calculated and used for identifying different tissues and compared to achieve the optimal recognition factor.Compared with the time domain approach,the frequency domain method could divide the spectra measured at different tissue points into different groups more stably and accurately,which could serve as a new method to assist the PS insertion.The results gained from this study are significant to the development of hi-tech medical instruments with independent intellectual property rights.

Different frequencies of electroacupuncture and semen coicis decrease glial fibrillary acidic protein expression in rats with hemisection spinal cord injury

This study established the following groups of rats： a normal group, a sham surgery group, a spinal cord injury model group, a low-frequency electroacupuncture group, a high-frequency electroacupuncture group and a semen coicis group. In all but the normal and sham surgery groups the left half of Tlo was transected. Four hours after model induction, 5-Hz and 100-Hz electroacupuncture were used to stimulate the acupoints I-luantiao （GB 30）, Zusan/i （ST 36）, Zhiyan9 （DU 9） and Xuanshu （DU 5）, or crude extract from semen coicis was intraperitoneally injected, for 8 consecutive weeks. The results indicated that electroacupuncture stimulation and intraperitoneal injection of semen coicis improved the morphology of spinal cord tissue, promoted the recovery of motion-evoked potentials, suppressed glial fibrillary acidic protein expression, and ameliorated motor function in rats with hemisection spinal cord injury. The effects of high-frequency （100 Hz） electroacupuncture ancl semen coicis were significant.

Reinforced interface endows the lithium anode with stable cycle at high-temperature of 80℃

Embracing ultrahigh theoretical capacity of 3860 mA h g^(-1)and the lowest reduction potential of-3.04 V(versus standard hydrogen electrode),lithium(Li) is considered as the "holy grail" material for pursuing higher energy density,of which application has been challenged due to the unstable interface caused by the non-uniform electrodeposition as well as high chemical activity.Operating at higher temperature can be recommended to uniform electrodeposition of Li metal.Nevertheless,the intrinsic side-reaction between Li metal anode and electrolyte is inevitably aggravated and thus fosters the failure of Li metal anode rapidly with uneven electrodeposition.Here,a kind of temperature-tolerated ionic liquid(1-methyl-3-ethylimidazole bis(fluorosulfo nyl)imide/lithium bis(trifluoromethylsulfo nyl)imide,EF/LT)based electrolyte that matrixed with poly(vinylidene fluoride-hexafluoropropylene) was designed to maintain the interfacial stabilization of Li metal due to the weak interfacial reaction and uniform electrodeposition at high temperature of 80℃.It is the matter that the 660-h cycle with lower polarization is achieved with EF/LT-based electrolyte at temperature of 80 ℃ and the full cell embraces outstanding cyclic performance,without capacity fading within 100 cycles.Delighting,a door for practical application of Li metal anode for higher energy density as the carbon neutrality progresses in the blooming human society has been opened gradually.

ON THE COMPLETE 2-DIMENSIONALλ-TRANSLATORS WITH A SECOND FUNDAMENTAL FORM OF CONSTANT LENGTH

In this article we study the two-dimensional completeλ-translators immersed in the Euclidean space R^3 and Minkovski space R1^ 3.We obtain two classification theorems:one for two-dimensional completeλ-translators x:M 2→R^3 and one for two-dimensional complete space-likeλ-translators x:M 2→R1^3,with a second fundamental form of constant length.

A Unified Bit-to-Symbol Mapping for Generalized Constellation Modulation

Gray mapping is a well-known way to improve the performance of regular constellation modulation,but it is challenging to be applied directly for irregular alternative.To address this issue,in this paper,a unified bit-to-symbol mapping method is designed for generalized constellation modulation(i.e.,regular and irregular shaping).The objective of the proposed approach is to minimize the average bit error probability by reducing the hamming distance(HD)of symbols with larger values of pairwise error probability.Simulation results show that the conventional constellation modulation(i.e.,phase shift keying and quadrature amplitude modulation(QAM)with the proposed mapping rule yield the same performance as that of classical gray mapping.Moreover,the recently developed golden angle modulation(GAM)with the proposed mapping method is capable of providing around1 d B gain over the conventional mapping counterpart and offers comparable performance to QAM with Gray mapping.

Electro-chemo-mechanical design of polymer matrix in composited LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2) cathode endows solid-state batteries with superior performance

Nickel-rich LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811) cathode material has been widely concerned due to its high voltage,high specific capacity and excellent rate performance,which is considered as one of the most promising cathode materials for the next generation of high-energy-density solid-state lithium batteries.However,serious electro-chemo-mechanical degradation of Nickel-rich cathode during cycling,especially at a high voltage(over 4.5 V),constrains their large-scale application.Here,using the multiphysical simulation,highly-conductive polymer matrix with spontaneous stress-buffering effect was uncovered theoretically for reinforcing the electrochemical performance of composited NCM81 1 cathode through the visualization of uniform concentration distribution of Li-ion coupled with improved stress field inside NCM811 cathode.Thereupon,polyacrylonitrile(PAN) and soft polyvinylidene fluoride(PVDF) were selected as the polymer matrix to fabricate the composited NCM811 cathode(PVDFPAN@NCM811) for improving the electrochemical performance of the solid-state NMC811|Li full cells,which can maintain high capacity over 146.2 mA h g^(-1)after 200 cycles at a high voltage of 4.5 V.Suggestively,designing a multifunctional polymer matrix with high ionic conductivity and mechanical property can buffer the stress and maintain the integrity of the structure,which can be regarded as the door-opening avenue to realize the high electrochemical performance of Ni-rich cathode for solidstate batteries.

Effects of stimulating frequency of NIR LEDs light irradiation on forehead as quantified by EEG measurements

Near-infrared(NIR)light has been shown to produce a range of physiological effects in hunans,however,there is still no agreement on whether and how a single parameter,like the flicker frequency of NIR light,affects the brain.An 810 nm NIR LED was used as the stimulator.Fifty subjects participated in this experiment.Forty subjects were randomly divided into four groups.Each group underwent a 30-minute NIR LED radiation with four different frequencies(i.e.,0 Hz,5 Hz,10 Hz and 20 Hz,respectively)on the forehead.The remaining 10 subjects formed the control group,in which they underwent a 30-minute rest period without light radiation.EEG signals of all subjects during each test were recorded.Gravity frequency(GF),relative energy change,and sample entropy were analyzed.The experimental groups had larger GF values compared to the control group.Higher stimulation frequency would cause larger growth of GF(F=14.75,P<0.001).The amplitude of alpha waves relative energy increased,while theta waves decreased remarkably in the experimental groups(p<0.02),and the extent of increase/decrease was larger at higher stimulation frequency,compared to that of the control.Sample entropy of electrodes in the frontal areas were much larger than those in other brain areas in the experimental groups(p<0.001).Larger frequency of the NIR LED light would cause more distinct brain activities in the stimulated areas.It indicates that NIR LED light may have a positive effect on modulating brain activity.These results may help improve the design of photobiomodulation treatments in the future.

Monte Carlo and phantom study in the brain edema models

Because the brain edema has a crucial impact on morbidity and mortality,it is important to develop a noninvasive method to monitor the process of the brain edema effectively.When the brain edema occurs,the optical properties of the brain will change.The goal of this study is to access the feasibility and reliability of using noninvasive near-infrared spectroscopy(NIRS)monitoring method to measure the brain edema.Specifically,three models,including the water content changes in the cerebrospinal fuid(CSF),gray matter and white matter,were explored.Moreover,these models were numerically simulated by the Monte Carlo studies.Then,the phantom experiments were performed to investigate the light intensity which was measured at different detecting radius on the tissue surface.The results indicated that the light intensity correlated well with the conditions of the brain edema and the detecting radius.Briefly,at the detect ing radius of 3.0 cm and 4.0 cm,the light intensity has a high response to the change of tissue parameters and optical properties.Thus,it is possible to monitor the brain edema noninvasively by NIRS method and the light intensity is a reliable and simple parameter to assess the brain edema.

Performance Analysis for Orthogonal Time Frequency Space Modulation Systems with Generalized Waveform

Orthogonal time-frequency space(OTFS),which exhibits beneficial advantages in high-mobility scenarios,has been considered as a promising technology in future wireless communication systems.In this paper,a universal model for OTFS systems with generalized waveform has been developed.Furthermore,the average bit error probability(ABEP)upper bounds of the optimal maximum likelihood(ML)detector are first derived for OTFS systems with generalized waveforms.Specifically,for OTFS systems with the ideal waveform,we elicit the ABEP bound by recombining the transmitted signal and the received signal.For OTFS systems with practical waveforms,a universal ABEP upper bound expression is derived using moment-generating function(MGF),which is further extended to MIMO-OTFS systems.Numerical results validate that our theoretical ABEP upper bounds are concur with the simulation performance achieved by ML detectors.