CLEC3A gene three polymorphisms and risk of gastric cancer in Northwestern Chinese population

This study aimed to evaluate the association between the CLEC3A gene polymorphisms(rs2735401/rs2293776/rs2072665)and the gastric cancer risk in the Northwestern Chinese population.A hospital-based case-control study was conducted on 681 cases and 756 healthy controls.Odds ratio(OR)and 95%confidence intervals(CI)were applied to evaluate the association of the CLEC3A polymorphisms on gastric cancer risk.We found that there was no significant association between the CLEC3A polymorphisms and gastric cancer susceptibility,which was detected in the main analysis or stratification analyses of age,gender,and clinical stages.Our findings verified that the CLEC3A polymorphisms are not associated with gastric cancer susceptibility in the Northwestern Chinese population;other polymorphisms should be investigated to further clarify the susceptibility to gastric cancer.

人细小病毒B19分子生物学研究进展

人细小病毒B19(Human parvovirus B19,简称B19病毒),是目前为止已知能够感染并引起人类疾病的两种细小病毒科成员之一。B19病毒作为一种重要病原,能够引起如儿童传染性红斑、急性再障危象、胎儿水肿甚至死胎等疾病。文中从B19病毒基因型、病毒受体、基因组结构特点与复制、病毒转录与转录后调控、病毒非结构和结构蛋白特点与功能以及病毒诊断及抗病毒药物研究策略6个方面来综述B19病毒的最新研究进展,以期为B19病毒致病机制的深入研究与治疗诊断策略的制定提供参考。