慢性非特异性腰痛(nonspecific chronic low back pain,NSCLBP)是一种常见疾病,已经引起了广泛关注,但发病机制尚不明确。近年来,借助相关设备研究NSCLBP发生发展的生物力学机制越来越受到重视。本文以腰椎核心功能屈伸运动为重点,综述...慢性非特异性腰痛(nonspecific chronic low back pain,NSCLBP)是一种常见疾病,已经引起了广泛关注,但发病机制尚不明确。近年来,借助相关设备研究NSCLBP发生发展的生物力学机制越来越受到重视。本文以腰椎核心功能屈伸运动为重点,综述国内外关于NSCLBP腰椎屈伸生物力学特征的研究进展,通过对具体研究方法及观察指标的深入探讨及总结展望,发现患者运动学、动力学、表面肌电等参数存在异常征象,为探索NSCLBP发病机制及其科学防治开拓思路。展开更多
目的:探讨推拿通过p38丝裂原活化蛋白激酶(MAPK)信号通路抑制脊髓背角中枢敏化从而参与腰椎间盘突出症(L D H)大鼠镇痛的作用机制。方法:将32只大鼠随机分为假手术组、模型组、推拿组、推拿+p38激动剂组,采用背根神经节持续压迫(CCD)模...目的:探讨推拿通过p38丝裂原活化蛋白激酶(MAPK)信号通路抑制脊髓背角中枢敏化从而参与腰椎间盘突出症(L D H)大鼠镇痛的作用机制。方法:将32只大鼠随机分为假手术组、模型组、推拿组、推拿+p38激动剂组,采用背根神经节持续压迫(CCD)模型模拟LDH病理变化。推拿组大鼠在造模后第4天开始推拿干预术侧委中穴,推拿+p38激动剂组在此基础上鞘内注射Anisomycin。实验过程中,采用电子Von Frey对大鼠右后足缩足阈值(P W T)测试以观察机械痛阈值变化;干预结束后取大鼠L4-L6段脊髓背角组织,采用Western Bolt检测p38MAPK、p-p38MAPK以及炎症因子肿瘤坏死因子(TNF)-α、白细胞介素(IL)-1β蛋白表达水平。结果:模型组P W T造模后下降趋势明显,且均显著低于同期假手术组(P<0.01);推拿组P W T在造模后先降低后上升,并在第10至21天均显著高于同期模型组(P<0.01);推拿+p38激动剂组P W T在造模后先降低后保持稳定,但均显著低于同期推拿组(P<0.01)。Western Blot结果显示,与假手术组比较,模型组大鼠脊髓背角中p38MAPK、p-p38MAPK、TNF-α、IL-1β蛋白表达均显著升高(P<0.01);与模型组比较,推拿干预后的大鼠p38MAPK、p-p38MAPK、TNF-α、IL-1β蛋白表达均显著降低(P<0.01,P<0.05);与单纯推拿比较,推拿+p38激动剂组大鼠p38MAPK、p-p38MAPK、TNF-α、IL-1β蛋白表达均显著升高(P<0.01)。结论:推拿可能通过p38MAPK信号通路调控下游炎症反应,进而抑制脊髓背角中枢敏化从而参与LDH的镇痛环节。展开更多
Objective To analyze the clinical application of manual therapy(MT)to tumor-related adverse reactions via summarizing the research at home and abroad,in order to provide more theoretical evidence for the clinical prom...Objective To analyze the clinical application of manual therapy(MT)to tumor-related adverse reactions via summarizing the research at home and abroad,in order to provide more theoretical evidence for the clinical promotion of MT.Methods We searched 7 Chinese and English databases,including China National Knowledge Infrastructure(CNKI),Wanfang Academic Journal Full-text Database(Wanfang),Chongqing VIP Database(CQVIP),PubMed,Excerpta Medica Database(EMBASE),Ovid and EBSCO.The publication date was between the establishment date of the database and December 31,2020.We screened the literature according to the inclusion and exclusion criteria,and then sorted and analyzed the selected information.Results A total of 46 papers were analyzed.Most studies focused on the adverse reactions in breast cancer patients.MT interventions demonstrated the best efficacy for fatigue,followed by pain,depression and anxiety.In different MT interventions,Tuina(Chinese therapeutic massage)was mainly adopted for fatigue,pain,anxiety,depression,and limb dysfunctions.Acupoint pressing was mainly adopted for gastrointestinal and psychological problems such as abdominal bloating,insomnia,depression and anxiety.The application of reflexotherapy was similar to that of Tuina.Conclusion MT can alleviate various adverse reactions by effectively relieving patients’somatic symptoms and improving their psychological states and overall functions.It can be popularized as a significant non-drug therapy.Currently,however,the clinical application of MT is neither extensive nor has sufficient basic research.Consequently,we should attach importance to this application.展开更多
文摘慢性非特异性腰痛(nonspecific chronic low back pain,NSCLBP)是一种常见疾病,已经引起了广泛关注,但发病机制尚不明确。近年来,借助相关设备研究NSCLBP发生发展的生物力学机制越来越受到重视。本文以腰椎核心功能屈伸运动为重点,综述国内外关于NSCLBP腰椎屈伸生物力学特征的研究进展,通过对具体研究方法及观察指标的深入探讨及总结展望,发现患者运动学、动力学、表面肌电等参数存在异常征象,为探索NSCLBP发病机制及其科学防治开拓思路。
文摘目的:探讨推拿通过p38丝裂原活化蛋白激酶(MAPK)信号通路抑制脊髓背角中枢敏化从而参与腰椎间盘突出症(L D H)大鼠镇痛的作用机制。方法:将32只大鼠随机分为假手术组、模型组、推拿组、推拿+p38激动剂组,采用背根神经节持续压迫(CCD)模型模拟LDH病理变化。推拿组大鼠在造模后第4天开始推拿干预术侧委中穴,推拿+p38激动剂组在此基础上鞘内注射Anisomycin。实验过程中,采用电子Von Frey对大鼠右后足缩足阈值(P W T)测试以观察机械痛阈值变化;干预结束后取大鼠L4-L6段脊髓背角组织,采用Western Bolt检测p38MAPK、p-p38MAPK以及炎症因子肿瘤坏死因子(TNF)-α、白细胞介素(IL)-1β蛋白表达水平。结果:模型组P W T造模后下降趋势明显,且均显著低于同期假手术组(P<0.01);推拿组P W T在造模后先降低后上升,并在第10至21天均显著高于同期模型组(P<0.01);推拿+p38激动剂组P W T在造模后先降低后保持稳定,但均显著低于同期推拿组(P<0.01)。Western Blot结果显示,与假手术组比较,模型组大鼠脊髓背角中p38MAPK、p-p38MAPK、TNF-α、IL-1β蛋白表达均显著升高(P<0.01);与模型组比较,推拿干预后的大鼠p38MAPK、p-p38MAPK、TNF-α、IL-1β蛋白表达均显著降低(P<0.01,P<0.05);与单纯推拿比较,推拿+p38激动剂组大鼠p38MAPK、p-p38MAPK、TNF-α、IL-1β蛋白表达均显著升高(P<0.01)。结论:推拿可能通过p38MAPK信号通路调控下游炎症反应,进而抑制脊髓背角中枢敏化从而参与LDH的镇痛环节。
文摘Objective To analyze the clinical application of manual therapy(MT)to tumor-related adverse reactions via summarizing the research at home and abroad,in order to provide more theoretical evidence for the clinical promotion of MT.Methods We searched 7 Chinese and English databases,including China National Knowledge Infrastructure(CNKI),Wanfang Academic Journal Full-text Database(Wanfang),Chongqing VIP Database(CQVIP),PubMed,Excerpta Medica Database(EMBASE),Ovid and EBSCO.The publication date was between the establishment date of the database and December 31,2020.We screened the literature according to the inclusion and exclusion criteria,and then sorted and analyzed the selected information.Results A total of 46 papers were analyzed.Most studies focused on the adverse reactions in breast cancer patients.MT interventions demonstrated the best efficacy for fatigue,followed by pain,depression and anxiety.In different MT interventions,Tuina(Chinese therapeutic massage)was mainly adopted for fatigue,pain,anxiety,depression,and limb dysfunctions.Acupoint pressing was mainly adopted for gastrointestinal and psychological problems such as abdominal bloating,insomnia,depression and anxiety.The application of reflexotherapy was similar to that of Tuina.Conclusion MT can alleviate various adverse reactions by effectively relieving patients’somatic symptoms and improving their psychological states and overall functions.It can be popularized as a significant non-drug therapy.Currently,however,the clinical application of MT is neither extensive nor has sufficient basic research.Consequently,we should attach importance to this application.
