目的 评估中药痰浊阻肺协定方对慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者的临床疗效及对实验室指标的影响。方法 选取2021年1月至2022年12月于常德市第一人民医院住院治疗...目的 评估中药痰浊阻肺协定方对慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者的临床疗效及对实验室指标的影响。方法 选取2021年1月至2022年12月于常德市第一人民医院住院治疗的AECOPD患者191例,根据患者治疗意愿将其分为观察组(96例)和对照组(95例)。对照组患者接受常规西医治疗方案,观察组患者在此基础上口服本院中药痰浊阻肺协定方,疗程1周。比较两组患者的中医证候积分、慢性阻塞性肺病评估测试(COPD assessment test,CAT)、肺功能、实验室指标和疗效。结果 观察组患者的总有效率显著高于对照组(χ^(2)=4.573,P=0.030)。治疗后,两组患者的中医证候积分、CAT评分、超敏C反应蛋白(hypersensitive C-reaction protein,hsCRP)、白细胞介素-6(interleukin-6,IL-6)均显著低于本组治疗前,用力肺活量占预计值百分比(percentage of forced vital capacity to predicted value,FVC%)、第1秒用力呼气容积占预计值百分比(percentage of forced expiratory volume in one second to predicted value,FEV_(1)%)均显著高于本组治疗前(P<0.05);观察组患者的动脉血二氧化碳分压(arterial partial pressure of carbon dioxide,PaCO_(2))低于本组治疗前,动脉血氧分压(arterial partial pressure of oxygen,PaO_(2))高于本组治疗前(P<0.05);观察组患者的中医证候积分、CAT评分、hsCRP、IL-6均显著低于对照组,FVC%、FEV_(1)%、PaO_(2)均显著高于对照组(P<0.05)。结论 在西医治疗基础上辅以痰浊阻肺协定方可更有效改善AECOPD患者的临床症状,缓解体内炎症,有助于肺功能恢复,提高患者的生活质量。展开更多
Providing early safety warning for batteries in real-world applications is challenging.In this study,comprehensive thermal abuse experiments are conducted to clarify the multidimensional signal evolution of battery fa...Providing early safety warning for batteries in real-world applications is challenging.In this study,comprehensive thermal abuse experiments are conducted to clarify the multidimensional signal evolution of battery failure under various preload forces.The time-sequence relationship among expansion force,voltage,and temperature during thermal abuse under five categorised stages is revealed.Three characteristic peaks are identified for the expansion force,which correspond to venting,internal short-circuiting,and thermal runaway.In particular,an abnormal expansion force signal can be detected at temperatures as low as 42.4°C,followed by battery thermal runaway in approximately 6.5 min.Moreover,reducing the preload force can improve the effectiveness of the early-warning method via the expansion force.Specifically,reducing the preload force from 6000 to 1000 N prolongs the warning time(i.e.,227 to 398 s)before thermal runaway is triggered.Based on the results,a notable expansion force early-warning method is proposed that can successfully enable early safety warning approximately 375 s ahead of battery thermal runaway and effectively prevent failure propagation with module validation.This study provides a practical reference for the development of timely and accurate early-warning strategies as well as guidance for the design of safer battery systems.展开更多
Alzheimer's disease(AD)is a common cause of dementia,characterised by cerebral amyloid-βdeposition,pathological tau and neurodegeneration.The prodromal stage of AD(pAD)refers to patients with mild cognitive impai...Alzheimer's disease(AD)is a common cause of dementia,characterised by cerebral amyloid-βdeposition,pathological tau and neurodegeneration.The prodromal stage of AD(pAD)refers to patients with mild cognitive impairment(MCl)and evidence of AD's pathology.At this stage,disease-modifying interventions should be used to prevent the progression to dementia.Given the inherent heterogeneity of MCl,more specific biomarkers are needed to elucidate the underlying AD's pathology.Although the uses of cerebrospinal fluid and positron emission tomography are widely accepted methods for detecting AD's pathology,their clinical applications are limited by their high costs and invasiveness,particularly in low-income areas in China.Therefore,to improve the early detection of Alzheimer's disease(AD)pathology through cost-effective screening methods,a panel of 45neurologists,psychiatrists andgerontologistswas invited to establish a formal consensus on the screening of pAD in China.The supportive evidence and grades of recommendations are based on a systematic literature review andfocus group discussion.National meetings were held to allow participants to review,vote and provide their expert opinions to reach a consensus.A majority(two-thirds)decision was used for questions for which consensus could not be reached.Recommended screening methods are presented in this publication,including neuropsychological assessment,peripheral biomarkers and brain imaging.In addition,a general workflow for Screening pAD in China is established,which will help clinicians identify individuals at high risk and determine therapeutic targets.展开更多
In this paper, the preparation technique of lavender essential oil microcapsules and the construction method of aromatic textiles were expounded, and the research status of bed curtains and lavender microcapsules at h...In this paper, the preparation technique of lavender essential oil microcapsules and the construction method of aromatic textiles were expounded, and the research status of bed curtains and lavender microcapsules at home and abroad was analyzed and studied from the perspective of application in textiles. The application of lavender essential oil to bed curtains through the microcapsule technique was put forward to allow lavender essential oil to play its role of helping sleep in bed curtains. This paper expounded the material selection and preparation technique of lavender microcapsule agents, and put forward the preparation method of microcapsules with mixed solutions of pure Chinese medicine extracts and natural essences as core material and high-viscosity epoxy resin as wall materials. The post-processing techniques and the spray ironing method for clothing were studied and developed, and these techniques and methods were applied to bed curtains, and good results were obtained.展开更多
Cold-rolled 2024-T3 sheet alloy was subjected to bobbin-tool friction stir welding （BTFSW）. The microstructural characteristics and mechanical properties of the nugget zone in the as-welded state were investigated. ...Cold-rolled 2024-T3 sheet alloy was subjected to bobbin-tool friction stir welding （BTFSW）. The microstructural characteristics and mechanical properties of the nugget zone in the as-welded state were investigated. The results show that the equiaxed grain size of BTFSW 2024-T3 alloy decreases from 7.6 to 2.8 μm as the welding speed is increased from 80 to 120 mm/min; in addition, fine grains are generated in the nugget zone and the size distribution is non-uniform. All A12CuMg （S＇） precipitates dissolve into the A1 matrix, whereas Mn-rich phases confirmed as T phases （Al20CuEMn3, A16Mn, or AlaMn） remain unchanged. The optimized parameters for BTFSW are veri- fied as the rotation speed of 350 r/min and the travel speed of 100 mm/min. The variations in precipitation and dislocation play more impor- tant roles than grain size in the nugget zone with respect to influencing the mechanical properties during the BTFSW process. After the BTFSW process, the fracture mode of base material 2024-T3 alloy transforms from ductile rupture to ductile-brittle mixed fi＇acture.展开更多
Surfaces with controllable micro structures are significant in fundamental development of superhydrophobicity. However,preparation of superhydrophobic surfaces with array structures on metal substrates is not effectiv...Surfaces with controllable micro structures are significant in fundamental development of superhydrophobicity. However,preparation of superhydrophobic surfaces with array structures on metal substrates is not effective using existing methods. A new method was presented to fabricate super-hydrophobic post arrays on aluminum(Al) substrates using mask electrochemical machining and fluoridation. Electrochemical etching was first applied on Al plates with pre-prepared photoresist arrays to make the post array structures. Surface modification was subsequently applied to reduce the surface energy, followed by interaction with water to realize superhydrophobicity. Simulation and experimental verification were conducted to investigate how machining parameters affect the array structures. Analysis of the water contact angle was implemented to explore the relationship between wettability and micro structures.The results indicate that superhydrophobic surfaces with controllable post structures can be fabricated through this proposed method, producing surfaces with high water static contact angles.展开更多
文摘目的 评估中药痰浊阻肺协定方对慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者的临床疗效及对实验室指标的影响。方法 选取2021年1月至2022年12月于常德市第一人民医院住院治疗的AECOPD患者191例,根据患者治疗意愿将其分为观察组(96例)和对照组(95例)。对照组患者接受常规西医治疗方案,观察组患者在此基础上口服本院中药痰浊阻肺协定方,疗程1周。比较两组患者的中医证候积分、慢性阻塞性肺病评估测试(COPD assessment test,CAT)、肺功能、实验室指标和疗效。结果 观察组患者的总有效率显著高于对照组(χ^(2)=4.573,P=0.030)。治疗后,两组患者的中医证候积分、CAT评分、超敏C反应蛋白(hypersensitive C-reaction protein,hsCRP)、白细胞介素-6(interleukin-6,IL-6)均显著低于本组治疗前,用力肺活量占预计值百分比(percentage of forced vital capacity to predicted value,FVC%)、第1秒用力呼气容积占预计值百分比(percentage of forced expiratory volume in one second to predicted value,FEV_(1)%)均显著高于本组治疗前(P<0.05);观察组患者的动脉血二氧化碳分压(arterial partial pressure of carbon dioxide,PaCO_(2))低于本组治疗前,动脉血氧分压(arterial partial pressure of oxygen,PaO_(2))高于本组治疗前(P<0.05);观察组患者的中医证候积分、CAT评分、hsCRP、IL-6均显著低于对照组,FVC%、FEV_(1)%、PaO_(2)均显著高于对照组(P<0.05)。结论 在西医治疗基础上辅以痰浊阻肺协定方可更有效改善AECOPD患者的临床症状,缓解体内炎症,有助于肺功能恢复,提高患者的生活质量。
基金supported by the National Key R&D Program of China(2022YFB2404300)the National Natural Science Foundation of China(NSFC Nos.52177217 and 52106244)。
文摘Providing early safety warning for batteries in real-world applications is challenging.In this study,comprehensive thermal abuse experiments are conducted to clarify the multidimensional signal evolution of battery failure under various preload forces.The time-sequence relationship among expansion force,voltage,and temperature during thermal abuse under five categorised stages is revealed.Three characteristic peaks are identified for the expansion force,which correspond to venting,internal short-circuiting,and thermal runaway.In particular,an abnormal expansion force signal can be detected at temperatures as low as 42.4°C,followed by battery thermal runaway in approximately 6.5 min.Moreover,reducing the preload force can improve the effectiveness of the early-warning method via the expansion force.Specifically,reducing the preload force from 6000 to 1000 N prolongs the warning time(i.e.,227 to 398 s)before thermal runaway is triggered.Based on the results,a notable expansion force early-warning method is proposed that can successfully enable early safety warning approximately 375 s ahead of battery thermal runaway and effectively prevent failure propagation with module validation.This study provides a practical reference for the development of timely and accurate early-warning strategies as well as guidance for the design of safer battery systems.
基金the National Natural Science Foundation of China(82171198,U20A20354)the Sci-Tech Innovation 2030 Agenda of China(2022ZD0211603).
文摘Alzheimer's disease(AD)is a common cause of dementia,characterised by cerebral amyloid-βdeposition,pathological tau and neurodegeneration.The prodromal stage of AD(pAD)refers to patients with mild cognitive impairment(MCl)and evidence of AD's pathology.At this stage,disease-modifying interventions should be used to prevent the progression to dementia.Given the inherent heterogeneity of MCl,more specific biomarkers are needed to elucidate the underlying AD's pathology.Although the uses of cerebrospinal fluid and positron emission tomography are widely accepted methods for detecting AD's pathology,their clinical applications are limited by their high costs and invasiveness,particularly in low-income areas in China.Therefore,to improve the early detection of Alzheimer's disease(AD)pathology through cost-effective screening methods,a panel of 45neurologists,psychiatrists andgerontologistswas invited to establish a formal consensus on the screening of pAD in China.The supportive evidence and grades of recommendations are based on a systematic literature review andfocus group discussion.National meetings were held to allow participants to review,vote and provide their expert opinions to reach a consensus.A majority(two-thirds)decision was used for questions for which consensus could not be reached.Recommended screening methods are presented in this publication,including neuropsychological assessment,peripheral biomarkers and brain imaging.In addition,a general workflow for Screening pAD in China is established,which will help clinicians identify individuals at high risk and determine therapeutic targets.
基金Supported by Undergraduate Training Program for Innovation and Entrepreneurship of Guangxi University of Chinese Medicine in 2023(S202310600084)。
文摘In this paper, the preparation technique of lavender essential oil microcapsules and the construction method of aromatic textiles were expounded, and the research status of bed curtains and lavender microcapsules at home and abroad was analyzed and studied from the perspective of application in textiles. The application of lavender essential oil to bed curtains through the microcapsule technique was put forward to allow lavender essential oil to play its role of helping sleep in bed curtains. This paper expounded the material selection and preparation technique of lavender microcapsule agents, and put forward the preparation method of microcapsules with mixed solutions of pure Chinese medicine extracts and natural essences as core material and high-viscosity epoxy resin as wall materials. The post-processing techniques and the spray ironing method for clothing were studied and developed, and these techniques and methods were applied to bed curtains, and good results were obtained.
文摘Cold-rolled 2024-T3 sheet alloy was subjected to bobbin-tool friction stir welding （BTFSW）. The microstructural characteristics and mechanical properties of the nugget zone in the as-welded state were investigated. The results show that the equiaxed grain size of BTFSW 2024-T3 alloy decreases from 7.6 to 2.8 μm as the welding speed is increased from 80 to 120 mm/min; in addition, fine grains are generated in the nugget zone and the size distribution is non-uniform. All A12CuMg （S＇） precipitates dissolve into the A1 matrix, whereas Mn-rich phases confirmed as T phases （Al20CuEMn3, A16Mn, or AlaMn） remain unchanged. The optimized parameters for BTFSW are veri- fied as the rotation speed of 350 r/min and the travel speed of 100 mm/min. The variations in precipitation and dislocation play more impor- tant roles than grain size in the nugget zone with respect to influencing the mechanical properties during the BTFSW process. After the BTFSW process, the fracture mode of base material 2024-T3 alloy transforms from ductile rupture to ductile-brittle mixed fi＇acture.
基金Supported by National Natural Science Foundation of China(Grant No.51605078)Science Fund for Creative Research Groups of NSFC(51621064)National Basic Research Program of China(973 Program,Grant No.2015CB057304)
文摘Surfaces with controllable micro structures are significant in fundamental development of superhydrophobicity. However,preparation of superhydrophobic surfaces with array structures on metal substrates is not effective using existing methods. A new method was presented to fabricate super-hydrophobic post arrays on aluminum(Al) substrates using mask electrochemical machining and fluoridation. Electrochemical etching was first applied on Al plates with pre-prepared photoresist arrays to make the post array structures. Surface modification was subsequently applied to reduce the surface energy, followed by interaction with water to realize superhydrophobicity. Simulation and experimental verification were conducted to investigate how machining parameters affect the array structures. Analysis of the water contact angle was implemented to explore the relationship between wettability and micro structures.The results indicate that superhydrophobic surfaces with controllable post structures can be fabricated through this proposed method, producing surfaces with high water static contact angles.
