目的:为了解小鼠BMAL1蛋白的结构和功能。方法:从NCBI数据库中获取小鼠BMAL1蛋白氨基酸序列,利用TMHMM Server v.2.0、ExPAsy、InterPro等在线软件分析其生物学特征,并通过STRING构建BMAL1蛋白相互作用网络。结果:BMAL1蛋白是由626个氨...目的:为了解小鼠BMAL1蛋白的结构和功能。方法:从NCBI数据库中获取小鼠BMAL1蛋白氨基酸序列,利用TMHMM Server v.2.0、ExPAsy、InterPro等在线软件分析其生物学特征,并通过STRING构建BMAL1蛋白相互作用网络。结果:BMAL1蛋白是由626个氨基酸构成,进化过程保守的不稳定亲水性蛋白。该蛋白二级结构主要为无规则卷曲,存在多个磷酸化和乙酰化位点,其相互作用蛋白大多与心血管疾病(cardiovascular disease,CVD)相关。结论:通过分析BMAL1蛋白结构和功能,提示其在动脉粥样硬化(atherosclerosis,AS)以及CVD疾病中具有潜在临床价值。展开更多
Pharmaceuticals and personal care products(PPCPs)are a new kind of contaminant widely existing in the surface water and groundwater environment.In recent years,PPCPs have been received widely attention from many resea...Pharmaceuticals and personal care products(PPCPs)are a new kind of contaminant widely existing in the surface water and groundwater environment.In recent years,PPCPs have been received widely attention from many researchers.The migration and transformation of PPCPs are mainly photolysis,biodegradation,adsorption and hydrolysis in aquifer environment.The influencing factors of PPCPs migration include PPCPs’own physical and chemical properties,types and contents of organic matter,pH,lithology,geotechnical structure and the thickness of vadose zone,etc.At present,the research of PPCPs in China is still in the primary stage,especially on the contaminant in aquifer system.Therefore,the research in this field needs to be further strengthened.展开更多
文摘目的:为了解小鼠BMAL1蛋白的结构和功能。方法:从NCBI数据库中获取小鼠BMAL1蛋白氨基酸序列,利用TMHMM Server v.2.0、ExPAsy、InterPro等在线软件分析其生物学特征,并通过STRING构建BMAL1蛋白相互作用网络。结果:BMAL1蛋白是由626个氨基酸构成,进化过程保守的不稳定亲水性蛋白。该蛋白二级结构主要为无规则卷曲,存在多个磷酸化和乙酰化位点,其相互作用蛋白大多与心血管疾病(cardiovascular disease,CVD)相关。结论:通过分析BMAL1蛋白结构和功能,提示其在动脉粥样硬化(atherosclerosis,AS)以及CVD疾病中具有潜在临床价值。
基金This study was supported by National Natural Science Foundation of China(No.4197021272).
文摘Pharmaceuticals and personal care products(PPCPs)are a new kind of contaminant widely existing in the surface water and groundwater environment.In recent years,PPCPs have been received widely attention from many researchers.The migration and transformation of PPCPs are mainly photolysis,biodegradation,adsorption and hydrolysis in aquifer environment.The influencing factors of PPCPs migration include PPCPs’own physical and chemical properties,types and contents of organic matter,pH,lithology,geotechnical structure and the thickness of vadose zone,etc.At present,the research of PPCPs in China is still in the primary stage,especially on the contaminant in aquifer system.Therefore,the research in this field needs to be further strengthened.
