Enantioselective aldol condensation under catalytic condition remains a challenging task in modern organic synthesis,and numerous efforts have been directed to this area.In particular,the direct catalytic asymmetric a...Enantioselective aldol condensation under catalytic condition remains a challenging task in modern organic synthesis,and numerous efforts have been directed to this area.In particular,the direct catalytic asymmetric aldol reaction is very attractive considering the requirement of atom efficiency.This has been studied only recently,and several very practical processes have been developed.We have recently initiated a study on the direct asymmetric aldol type reaction with ethyl diazoacetate as nucleophile.Moderate enantioselectivities(65%~91%ee)were achieved in the condensation of aldehydes with ethyl diazoacetate catalyzed by the chiral complex of BINOL derivatives-Zr(OBu-t)_(4).展开更多
文摘Enantioselective aldol condensation under catalytic condition remains a challenging task in modern organic synthesis,and numerous efforts have been directed to this area.In particular,the direct catalytic asymmetric aldol reaction is very attractive considering the requirement of atom efficiency.This has been studied only recently,and several very practical processes have been developed.We have recently initiated a study on the direct asymmetric aldol type reaction with ethyl diazoacetate as nucleophile.Moderate enantioselectivities(65%~91%ee)were achieved in the condensation of aldehydes with ethyl diazoacetate catalyzed by the chiral complex of BINOL derivatives-Zr(OBu-t)_(4).
