Dissipative Kerr solitons from optical microresonators,commonly referred to as soliton microcombs,have been developed for a broad range of applications,including precision measurement,optical frequency synthesis,and u...Dissipative Kerr solitons from optical microresonators,commonly referred to as soliton microcombs,have been developed for a broad range of applications,including precision measurement,optical frequency synthesis,and ultrastable microwave and millimeter wave generation,all on a chip.An important goal for microcombs is self-referencing,which requires octave-spanning bandwidths to detect and stabilize the comb carrier envelope offset frequency.Further,detection and locking of the comb spacings are often achieved using frequency division by electro-optic modulation.The thin-film lithium niobate photonic platform,with its low loss,strong second-and third-order nonlinearities,as well as large Pockels effect,is ideally suited for these tasks.However,octave-spanning soliton microcombs are challenging to demonstrate on this platform,largely complicated by strong Raman effects hindering reliable fabrication of soliton devices.Here,we demonstrate entirely connected and octave-spanning soliton microcombs on thin-film lithium niobate.With appropriate control over microresonator free spectral range and dissipation spectrum,we show that soliton-inhibiting Raman effects are suppressed,and soliton devices are fabricated with near-unity yield.Our work offers an unambiguous method for soliton generation on strongly Raman-active materials.Further,it anticipates monolithically integrated,self-referenced frequency standards in conjunction with established technologies,such as periodically poled waveguides and electro-optic modulators,on thin-film lithium niobate.展开更多
Objective:to evaluate the clinical efficacy and safety of ultra-early lumbar puncture drainage of cerebrospinal fluid(CSF)in patients with aneurysmal subarachnoid hemorrhage(SAH).Methods:patients(n=140)with aneurysmal...Objective:to evaluate the clinical efficacy and safety of ultra-early lumbar puncture drainage of cerebrospinal fluid(CSF)in patients with aneurysmal subarachnoid hemorrhage(SAH).Methods:patients(n=140)with aneurysmal SAH were randomly divided into observation group(n=70)and control group(n=70).After admission,CSF was drained by ultra-early lumbar puncture in the observation group and intermittent lumbar puncture after aneurysm operation in the control group.The incidences of early aneurysm rupture,acute hydrocephalus and delayed hydrocephalus were compared between the two groups.Results:there was no significant diflerence in the incidence of early-ruptured aneurysm and acute hydrocephalus between the two groups,but the incidence of delayed hydrocephalus in the observation group was significantly lower than that in the control group.Conclusion:ultra-early lumbar puncture drainage of CSF in anexirysmal SAH can effectively reduce the incidence of long-term delayed hydrocephalus and it is a safe and effective treatment.展开更多
Objective:to investigate the effect of improving prehospital hypotension and hypoxemia on the prognosis of different subgroups of patients with traumatic brain injury(TBI).Methods:medical staff were trained about the ...Objective:to investigate the effect of improving prehospital hypotension and hypoxemia on the prognosis of different subgroups of patients with traumatic brain injury(TBI).Methods:medical staff were trained about the prehospital first aid for 2 months to fully master the methods of improving prehospital hypotension and hypoxemia,then the prognosis of TBI patients pre-and post-training for 12 months was collected and recorded.The prognostic differences of different TBI subgroups were discussed through data analysis.Results:after the training,the proportion of prehospital hypotension and hypoxemia in TBI patients decreased by 77%(8.5%vs.1.9%)and 63%(9.9%vs.3.6%,P<0.05),respectively.However,only the prognosis of moderate and severe TBI patients was improved,the proportion of patients with"good prognosis^increased by 14%(61.4%vs.70.5%,respectively)and 62%(35.6%vs.58%),and no significant effect showed in mild and critical TBI patients.Conclusion:reducing the incidence of prehospital hypoxemia and hypotension can improve the prognosis of moderate and severe TBI patients,while no significant effect on mild and critical TBI patients.展开更多
The recent emergence of thin-film lithium niobate(TFLN)has extended the landscape of integrated photonics.This has been enabled by the commercialization of TFLN wafers and advanced nanofabrication of TFLN such as high...The recent emergence of thin-film lithium niobate(TFLN)has extended the landscape of integrated photonics.This has been enabled by the commercialization of TFLN wafers and advanced nanofabrication of TFLN such as high-quality dry etching.However,fabrication imperfections still limit the propagation loss to a few dB/m,restricting the impact of this platform.Here,we demonstrate TFLN microresonators with a record-high intrinsic quality(Q)factor of twenty-nine million,corresponding to an ultra-low propagation loss of 1.3 dB/m.We present spectral analysis and the statistical distribution of Q factors across different resonator geometries.Our work pushes the fabrication limits of TFLN photonics to achieve a Q factor within 1 order of magnitude of the material limit.展开更多
Manipulating the frequency and bandwidth of nonclassical light is essential for implementing frequency-encoded/multiplexed quantum computation,communication,and networking protocols,and for bridging spectral mismatch ...Manipulating the frequency and bandwidth of nonclassical light is essential for implementing frequency-encoded/multiplexed quantum computation,communication,and networking protocols,and for bridging spectral mismatch among various quantum systems.However,quantum spectral control requires a strong nonlinearity mediated by light,microwave,or acoustics,which is challenging to realize with high efficiency,low noise,and on an integrated chip.Here,we demonstrate both frequency shifting and bandwidth compression of heralded single-photon pulses using an integrated thin-film lithium niobate(TFLN)phase modulator.We achieve record-high electro-optic frequency shearing of telecom single photons over terahertz range(±641 GHz or±5.2 nm),enabling high visibility quantum interference between frequency-nondegenerate photon pairs.We further operate the modulator as a time lens and demonstrate over eighteen-fold(6.55 nm to 0.35 nm)bandwidth compression of single photons.Our results showcase the viability and promise of on-chip quantum spectral control for scalable photonic quantum information processing.展开更多
基金supported by the Defense Advanced Research Projects Agency(HR001120C0137,D23AP00251-00)Office of Naval Research(N00014-22-C-1041)+4 种基金National Science Foundation(OMA-2137723,OMA2138068)U.S.Navy(N68335-22-C-0413)National Research Foundation of Korea.The device fabrication in this work was performed at the Harvard University Center for Nanoscale Systems(CNS)a member of the National Nanotechnology Coordinated Infrastructure Network(NNCI)which is supported by the National Science Foundation under NSF award no.ECCS-2025158.
文摘Dissipative Kerr solitons from optical microresonators,commonly referred to as soliton microcombs,have been developed for a broad range of applications,including precision measurement,optical frequency synthesis,and ultrastable microwave and millimeter wave generation,all on a chip.An important goal for microcombs is self-referencing,which requires octave-spanning bandwidths to detect and stabilize the comb carrier envelope offset frequency.Further,detection and locking of the comb spacings are often achieved using frequency division by electro-optic modulation.The thin-film lithium niobate photonic platform,with its low loss,strong second-and third-order nonlinearities,as well as large Pockels effect,is ideally suited for these tasks.However,octave-spanning soliton microcombs are challenging to demonstrate on this platform,largely complicated by strong Raman effects hindering reliable fabrication of soliton devices.Here,we demonstrate entirely connected and octave-spanning soliton microcombs on thin-film lithium niobate.With appropriate control over microresonator free spectral range and dissipation spectrum,we show that soliton-inhibiting Raman effects are suppressed,and soliton devices are fabricated with near-unity yield.Our work offers an unambiguous method for soliton generation on strongly Raman-active materials.Further,it anticipates monolithically integrated,self-referenced frequency standards in conjunction with established technologies,such as periodically poled waveguides and electro-optic modulators,on thin-film lithium niobate.
文摘Objective:to evaluate the clinical efficacy and safety of ultra-early lumbar puncture drainage of cerebrospinal fluid(CSF)in patients with aneurysmal subarachnoid hemorrhage(SAH).Methods:patients(n=140)with aneurysmal SAH were randomly divided into observation group(n=70)and control group(n=70).After admission,CSF was drained by ultra-early lumbar puncture in the observation group and intermittent lumbar puncture after aneurysm operation in the control group.The incidences of early aneurysm rupture,acute hydrocephalus and delayed hydrocephalus were compared between the two groups.Results:there was no significant diflerence in the incidence of early-ruptured aneurysm and acute hydrocephalus between the two groups,but the incidence of delayed hydrocephalus in the observation group was significantly lower than that in the control group.Conclusion:ultra-early lumbar puncture drainage of CSF in anexirysmal SAH can effectively reduce the incidence of long-term delayed hydrocephalus and it is a safe and effective treatment.
文摘Objective:to investigate the effect of improving prehospital hypotension and hypoxemia on the prognosis of different subgroups of patients with traumatic brain injury(TBI).Methods:medical staff were trained about the prehospital first aid for 2 months to fully master the methods of improving prehospital hypotension and hypoxemia,then the prognosis of TBI patients pre-and post-training for 12 months was collected and recorded.The prognostic differences of different TBI subgroups were discussed through data analysis.Results:after the training,the proportion of prehospital hypotension and hypoxemia in TBI patients decreased by 77%(8.5%vs.1.9%)and 63%(9.9%vs.3.6%,P<0.05),respectively.However,only the prognosis of moderate and severe TBI patients was improved,the proportion of patients with"good prognosis^increased by 14%(61.4%vs.70.5%,respectively)and 62%(35.6%vs.58%),and no significant effect showed in mild and critical TBI patients.Conclusion:reducing the incidence of prehospital hypoxemia and hypotension can improve the prognosis of moderate and severe TBI patients,while no significant effect on mild and critical TBI patients.
基金Defense Advanced Research Projects Agency(HR001120C0137)U.S.Navy(N68335-22-C-0413)+6 种基金Air Force Office of Scientific Research(FA9550-20-1-01015)Air Force Research Laboratory(FA864921P0781)National Aeronautics and Space Administration(80NSSC22K0262,80NSSC23PB442)National Science Foundation(EEC-1941583,OMA-2137723,2138068)Office of Naval Research(N00014-22-C-1041)National Institutes of Health(5R21EY031895-02)National Research Foundation of Korea。
文摘The recent emergence of thin-film lithium niobate(TFLN)has extended the landscape of integrated photonics.This has been enabled by the commercialization of TFLN wafers and advanced nanofabrication of TFLN such as high-quality dry etching.However,fabrication imperfections still limit the propagation loss to a few dB/m,restricting the impact of this platform.Here,we demonstrate TFLN microresonators with a record-high intrinsic quality(Q)factor of twenty-nine million,corresponding to an ultra-low propagation loss of 1.3 dB/m.We present spectral analysis and the statistical distribution of Q factors across different resonator geometries.Our work pushes the fabrication limits of TFLN photonics to achieve a Q factor within 1 order of magnitude of the material limit.
基金supported by Harvard Quantum Initiative(HQI),ARO/DARPA(W911NF2010248),AFOSR(FA9550-20-1-01015),DARPA LUMOS(HR0011-20-C-0137),DOE(DE-SC0020376),NSF(EEC-1941583,ECCS-1839197),and AFRL(FA9550-21-1-0056)support by HQI post-doctoral fellowship and A*STAR SERC Central Research Fund(CRF)support by the AQT Intelligent Quantum Networks and Technologies(INQNET)research program.
文摘Manipulating the frequency and bandwidth of nonclassical light is essential for implementing frequency-encoded/multiplexed quantum computation,communication,and networking protocols,and for bridging spectral mismatch among various quantum systems.However,quantum spectral control requires a strong nonlinearity mediated by light,microwave,or acoustics,which is challenging to realize with high efficiency,low noise,and on an integrated chip.Here,we demonstrate both frequency shifting and bandwidth compression of heralded single-photon pulses using an integrated thin-film lithium niobate(TFLN)phase modulator.We achieve record-high electro-optic frequency shearing of telecom single photons over terahertz range(±641 GHz or±5.2 nm),enabling high visibility quantum interference between frequency-nondegenerate photon pairs.We further operate the modulator as a time lens and demonstrate over eighteen-fold(6.55 nm to 0.35 nm)bandwidth compression of single photons.Our results showcase the viability and promise of on-chip quantum spectral control for scalable photonic quantum information processing.