In these times of despair when a nano-sized organism,the SARS-CoV-2,has rendered the human race helpless,made the global health status decline,and drowned the world economy,a ray of hope comes from another nano-sized ...In these times of despair when a nano-sized organism,the SARS-CoV-2,has rendered the human race helpless,made the global health status decline,and drowned the world economy,a ray of hope comes from another nano-sized particle,the exosome.The potential of mesenchymal stem cells has already been established in COVID-19;however,cell-based therapy has its risks.We thereby propose cell-free therapy using stem cells-derived exosomes to fight against COVID-19,as they can be a game-changer owing to their immunomodulatory nature,which combats the cytokine storm characterizing this disease,and their practical efficiency,which will realistically aid large access to therapy worldwide.展开更多
Neurodegenerative disorders are a vicious woe to the public health and wellness.Uncertainty in their underlying causes,lack of effective biomarkers for their early detection,existence of only supportive therapy,and th...Neurodegenerative disorders are a vicious woe to the public health and wellness.Uncertainty in their underlying causes,lack of effective biomarkers for their early detection,existence of only supportive therapy,and their ever rising incidence creates an unmatched need for targeted therapies.Mesenchymal Stem Cells(MSCs)have found to be promising candidates for regenerative and remedial therapy in neurodegenerative disorders,however several biological risks and practical issues impede in their translational utility.Deriving from MSCs are certain Extracellular Vesicles(EVs),which aid in the paracrine action of MSCs and have lately gained the scientific interest for their implacability in diverse set ups.Their cargo is of utmost importance and is being explored in various different diseases like heart diseases,neuronal diseases,respiratory diseases and hepatic diseases.They thereby hold the position of a likely prospective remedial candidate for therapy against neurodegenerative disorders.展开更多
文摘In these times of despair when a nano-sized organism,the SARS-CoV-2,has rendered the human race helpless,made the global health status decline,and drowned the world economy,a ray of hope comes from another nano-sized particle,the exosome.The potential of mesenchymal stem cells has already been established in COVID-19;however,cell-based therapy has its risks.We thereby propose cell-free therapy using stem cells-derived exosomes to fight against COVID-19,as they can be a game-changer owing to their immunomodulatory nature,which combats the cytokine storm characterizing this disease,and their practical efficiency,which will realistically aid large access to therapy worldwide.
文摘Neurodegenerative disorders are a vicious woe to the public health and wellness.Uncertainty in their underlying causes,lack of effective biomarkers for their early detection,existence of only supportive therapy,and their ever rising incidence creates an unmatched need for targeted therapies.Mesenchymal Stem Cells(MSCs)have found to be promising candidates for regenerative and remedial therapy in neurodegenerative disorders,however several biological risks and practical issues impede in their translational utility.Deriving from MSCs are certain Extracellular Vesicles(EVs),which aid in the paracrine action of MSCs and have lately gained the scientific interest for their implacability in diverse set ups.Their cargo is of utmost importance and is being explored in various different diseases like heart diseases,neuronal diseases,respiratory diseases and hepatic diseases.They thereby hold the position of a likely prospective remedial candidate for therapy against neurodegenerative disorders.
