A new method for the synthesis of 1,4-dihydropyridine(1,4-DHP)calcium channel antagonists felodipme, nitrendipine and their derivatives via papain-catalyzed three-component reactions of aldehyde,methyl acetoacetate an...A new method for the synthesis of 1,4-dihydropyridine(1,4-DHP)calcium channel antagonists felodipme, nitrendipine and their derivatives via papain-catalyzed three-component reactions of aldehyde,methyl acetoacetate and ethyl 3-aminocrotonate was developed.Operational simplicity,mild reaction conditions and eco-friendliness are the key features of this protocol.展开更多
A series of highly timctionalized 1,4-dihydropyridines was synthesized via one-pot multicomponent reactions of aromatic aldehyde,malononitrile and N-methyl-1-(methylthio)-2-nitroethenamine using Porcine pancreatic lip...A series of highly timctionalized 1,4-dihydropyridines was synthesized via one-pot multicomponent reactions of aromatic aldehyde,malononitrile and N-methyl-1-(methylthio)-2-nitroethenamine using Porcine pancreatic lipase(PPL)as catalyst in DMSO.This protocol is featured by mild reaction conditions,simple operation and environmental acceptability.展开更多
基金the National Natural Science Foundation of China(No.21706236)the China Postdoctoral Science Foundation (No.2016M592012)the Foundation for Selected Postdoctoral Project of Zhejiang Province,China(No.BSH1502150).
文摘A new method for the synthesis of 1,4-dihydropyridine(1,4-DHP)calcium channel antagonists felodipme, nitrendipine and their derivatives via papain-catalyzed three-component reactions of aldehyde,methyl acetoacetate and ethyl 3-aminocrotonate was developed.Operational simplicity,mild reaction conditions and eco-friendliness are the key features of this protocol.
基金the National Natural Science Foundation of China(No.21706236)the China Postdoctoral Science Foundation(No.2016M592012)the Foundation for Selected Postdoctoral Project of Zhejiang Province,China(No.BSH1502150).
文摘A series of highly timctionalized 1,4-dihydropyridines was synthesized via one-pot multicomponent reactions of aromatic aldehyde,malononitrile and N-methyl-1-(methylthio)-2-nitroethenamine using Porcine pancreatic lipase(PPL)as catalyst in DMSO.This protocol is featured by mild reaction conditions,simple operation and environmental acceptability.