Metal-organic frameworks(MOFs)composed of functional metal ions/clusters and suitable bridging ligands are highly designable,which have shown excellent catalytic activity as nanozymes and are promising for antibacteri...Metal-organic frameworks(MOFs)composed of functional metal ions/clusters and suitable bridging ligands are highly designable,which have shown excellent catalytic activity as nanozymes and are promising for antibacterial therapy.Herein,twodimensional(2D)copper MOF nanosheets(Cu-MOF NSs)as effective antibacterial agents were prepared through a simple onestep method.The 2D Cu-MOF NSs displayed a peroxidase-like activity toward H_(2)O_(2)decomposition into highly cytotoxic hydroxyl radicals(·OH).Notably,the 2D morphology of Cu-MOF NSs provides a high density of Cu^(2+)/Cu^(+)surface active sites,which could efficiently oxidize the proteins and lipids on the bacterial surface and induce the death of bacteria.It is found that the as-prepared 2D Cu-MOF NSs exhibited antibacterial properties against Staphylococcus aureus(S.aureus)and could efficiently eradicate the biofilm of S.aureus.Up to 99.9%bacteria were killed at a Cu-MOF concentration of 4μg/m L.This study opens a new avenue for the design of MOF-based antibacterial agents to combat pathogenic bacterial infections.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.52173271,51922022 and 51773013)the Beijing Outstanding Young Scientist Program(Grant No.BJJWZYJH01201910010024)+3 种基金the China Postdoctoral Science Foundation(Grant Nos.2021T140044 and 2020M670110)the Beijing Municipal Natural Science Foundation(Grant No.2214074)the Beijing Municipal Science and Technology Project(Grant No.Z191100006619099)the Fundamental Research Funds for the Central Universities(Grant Nos.BHYC1705A and XK1802-2)。
文摘Metal-organic frameworks(MOFs)composed of functional metal ions/clusters and suitable bridging ligands are highly designable,which have shown excellent catalytic activity as nanozymes and are promising for antibacterial therapy.Herein,twodimensional(2D)copper MOF nanosheets(Cu-MOF NSs)as effective antibacterial agents were prepared through a simple onestep method.The 2D Cu-MOF NSs displayed a peroxidase-like activity toward H_(2)O_(2)decomposition into highly cytotoxic hydroxyl radicals(·OH).Notably,the 2D morphology of Cu-MOF NSs provides a high density of Cu^(2+)/Cu^(+)surface active sites,which could efficiently oxidize the proteins and lipids on the bacterial surface and induce the death of bacteria.It is found that the as-prepared 2D Cu-MOF NSs exhibited antibacterial properties against Staphylococcus aureus(S.aureus)and could efficiently eradicate the biofilm of S.aureus.Up to 99.9%bacteria were killed at a Cu-MOF concentration of 4μg/m L.This study opens a new avenue for the design of MOF-based antibacterial agents to combat pathogenic bacterial infections.
