Background:The maintenance dosage of selexipag is categorized as low,medium or high.In order to assess the efficacy and safety of different dosages of selexipag for the risk stratification of pulmonary arterial hypert...Background:The maintenance dosage of selexipag is categorized as low,medium or high.In order to assess the efficacy and safety of different dosages of selexipag for the risk stratification of pulmonary arterial hypertension(PAH),we performed a sys-tematic review and meta-analysis.Methods:Studies assessing PAH risk stratification indices,such as the World Health Organization functional class(WHO-FC),six-minute walk distance(6MWD),N-terminal pro-B-type natriuretic peptide(NT-proBNP)level,right atrial pressure(RAP),cardiac index(CI)and mixed venous oxygen saturation(SvO2),were included.Results:Thirteen studies were included.Selexipag led to improvements in the 6MWD(MD:24.20 m,95%CI:10.74-37.67),NT-proBNP(SMD:-0.41,95%CI:-0.79-0.04),CI(MD:0.47 L/min/m^(2),95%CI:0.17-0.77)and WHO-FC(OR:0.564,95%CI:0.457-0.697).Subgroup analysis demonstrated that all three dosages improved the 6MWD.A moderate dosage led to improvements in the CI(MD:0.30 L/min/m^(2),95%CI:0.15-0.46)and WHO-FC(OR:0.589,95%CI:0.376-0.922).Within 6 months of treatment,only the WHO-FC and CI were significantly improved(OR:0.614,95%CI:0.380-0.993;MD:0.30 L/min/m^(2),95%CI:0.16-0.45,respectively).More than 6 months of treatment significantly improved the 6MWD,WHO-FC and NT-proBNP(MD:40.87 m,95%CI:10.97-70.77;OR:0.557,95%CI:0.440-0.705;SMD:-0.61,95%CI:-1.17-0.05,respectively).Conclusions:Low,medium,and high dosages of selexipag all exhibited good effects.When treatment lasted for more than 6 months,selexipag exerted obvious effects,even in the low-dosage group.This finding is important for guiding individualized treatments.展开更多
Early Cambrian shale is an important petroleum source rock around the world.Because of little drilling data and poor seismic data,until recently,organic matter enrichment of the Lower Cambrian Yuertusi and Xishanbulak...Early Cambrian shale is an important petroleum source rock around the world.Because of little drilling data and poor seismic data,until recently,organic matter enrichment of the Lower Cambrian Yuertusi and Xishanbulake formations shale is still an enigma in the Tarim Basin,northwestern China.Total organic carbon(TOC),major and trace element data of Cambrian shale samples from five boreholes have been analyzed to decipher the mechanism of the organic matter enrichment.The results show that the shales deposited in the western restricted intraplatform have much higher TOC contents(3.2%-19.8%,on average 11.0%)than those from the eastern basin(2.2%-10.2%,on average 4.5%).The paleoproductivity proxies(Ba,Ba/Al,P/Al)in the western restricted platform are much higher than those in the eastern basin.The trace element indicators such as V/Cr,Ni/Co,Mo-TOC and Mo_(EF)-U_(EF)suggest an anoxic environment across the basin,but a more restricted environment in the western intraplatform.The paleoproductivity rather than anoxic condition and hydrothermal activity are concluded to have resulted in the differentiation of the organic matter enrichment from the western intraplatform to eastern basin in the early Cambrian shales;the restricted environment was favorable for paleoproductivity and preservation of organic matter.展开更多
Previous studies have identified two emission modes in PSR B1859+07: a normal mode that has three prominent components in the average profile, with the trailing one being the brightest, and an anomalous mode(i.e., the...Previous studies have identified two emission modes in PSR B1859+07: a normal mode that has three prominent components in the average profile, with the trailing one being the brightest, and an anomalous mode(i.e., the A mode) where emissions seem to be shifted to an earlier phase. Within the normal mode, further analysis has revealed the presence of two submodes, i.e., the cW mode and c B mode, where the central component can appear either weak or bright. As for the anomalous mode, a new bright component emerges in the advanced phase while the bright trailing component in the normal mode disappears. New observations of PSR B1859+07 using the Fivehundred-meter Aperture Spherical Radio Telescope(FAST) have revealed the existence of a previously unknown emission mode, dubbed the Af mode. In this mode, all emission components seen in the normal and anomalous modes are detected. Notably, the mean polarization profiles of both the A and Af modes exhibit a jump in the orthogonal polarization angle modesin the bright leading component. The polarization angles for the central component in the original normal mode follow two distinct orthogonal polarization modes in the A and Af modes respectively. The polarization angles for the trailing component show almost the same but a small systematic shift in the A and Af modes, roughly following the values for the c W and cB modes. Those polarization features of this newly detected emission mode imply that the anomalous mode A of PSR B1859+07 is not a result of “phase shift”or “swooshes” of normal components, but simply a result of the varying intensities of different profile components.Additionally, subpulse drifting has been detected in the leading component of the Af mode.展开更多
We have carried out the Galactic Plane Pulsar Snapshot(GPPS)survey by using the Five-hundred-meter Aperture Spherical radio Telescope(FAST),the most sensitive systematic pulsar survey in the Galactic plane.In addition...We have carried out the Galactic Plane Pulsar Snapshot(GPPS)survey by using the Five-hundred-meter Aperture Spherical radio Telescope(FAST),the most sensitive systematic pulsar survey in the Galactic plane.In addition to more than 500 pulsars already discovered through normal periodical search,we report here the discovery of 76 new transient radio sources with sporadic strong pulses,detected by using the newly developed module for a sensitive single-pulse search.Their small DM values suggest that they all are Galactic rotating radio transients(RRATs).They show different properties in the follow-up observations.More radio pulses have been detected from 26 transient radio sources but no periods can be found due to a limited small number of pulses from all FAST observations.The followup observations show that 16 transient sources are newly identified as being the prototypes of RRATs with a period already determined from more detected sporadic pulses,and 10 sources are extremely nulling pulsars,and 24 sources are weak pulsars with sparse strong pulses.On the other hand,48 previously known RRATs have been detected by the FAST,either during verification observations for the GPPS survey or through targeted observations of applied normal FAST projects.Except for one RRAT with four pulses detected in a session of 5-minute observation and four RRATs with only one pulse detected in a session,sensitive FAST observations reveal that 43 RRATs are just generally weak pulsars with sporadic strong pulses or simply very nulling pulsars,so that the previously known RRATs always have an extreme emission state together with a normal hardly detectable weak emission state.This is echoed by the two normal pulsars J1938+2213 and J1946+1449 with occasional brightening pulses.Though strong pulses of RRATs are very outstanding in the energy distribution,their polarization angle variations follow the polarization angle curve of the averaged normal pulse profile,suggesting that the predominant sparse pulses of RRATs are emitted in the same region with the same geometry as normal weak pulsars.展开更多
基金Program of the National Natural Science Foundation of China,Grant/Award Number:81700045,81870042 and 82200065The Department Development Fund of Shanghai Pulmonary Hospital,Grant/Award Number:201906-0314+2 种基金The Program of Shanghai Pulmonary Hospital,Grant/Award Number:FKLY20011The Three-year Action Plan to Promote Clinical Skills and Clinical Innovation in Municipal Hospitals,Grant/Award Number:SHDC2020CR4021Young Talent Program of Shanghai Municipal Health Commission,Grant/Award Number:2022YQ070。
文摘Background:The maintenance dosage of selexipag is categorized as low,medium or high.In order to assess the efficacy and safety of different dosages of selexipag for the risk stratification of pulmonary arterial hypertension(PAH),we performed a sys-tematic review and meta-analysis.Methods:Studies assessing PAH risk stratification indices,such as the World Health Organization functional class(WHO-FC),six-minute walk distance(6MWD),N-terminal pro-B-type natriuretic peptide(NT-proBNP)level,right atrial pressure(RAP),cardiac index(CI)and mixed venous oxygen saturation(SvO2),were included.Results:Thirteen studies were included.Selexipag led to improvements in the 6MWD(MD:24.20 m,95%CI:10.74-37.67),NT-proBNP(SMD:-0.41,95%CI:-0.79-0.04),CI(MD:0.47 L/min/m^(2),95%CI:0.17-0.77)and WHO-FC(OR:0.564,95%CI:0.457-0.697).Subgroup analysis demonstrated that all three dosages improved the 6MWD.A moderate dosage led to improvements in the CI(MD:0.30 L/min/m^(2),95%CI:0.15-0.46)and WHO-FC(OR:0.589,95%CI:0.376-0.922).Within 6 months of treatment,only the WHO-FC and CI were significantly improved(OR:0.614,95%CI:0.380-0.993;MD:0.30 L/min/m^(2),95%CI:0.16-0.45,respectively).More than 6 months of treatment significantly improved the 6MWD,WHO-FC and NT-proBNP(MD:40.87 m,95%CI:10.97-70.77;OR:0.557,95%CI:0.440-0.705;SMD:-0.61,95%CI:-1.17-0.05,respectively).Conclusions:Low,medium,and high dosages of selexipag all exhibited good effects.When treatment lasted for more than 6 months,selexipag exerted obvious effects,even in the low-dosage group.This finding is important for guiding individualized treatments.
基金partly supported by the National Natural Science Foundation of China(Grant No.42241206,91955204)the Science and Technology Cooperation Project of the CNPC-SWPU Innovation Alliance(Grant No.4224100017,2020CX010101)。
文摘Early Cambrian shale is an important petroleum source rock around the world.Because of little drilling data and poor seismic data,until recently,organic matter enrichment of the Lower Cambrian Yuertusi and Xishanbulake formations shale is still an enigma in the Tarim Basin,northwestern China.Total organic carbon(TOC),major and trace element data of Cambrian shale samples from five boreholes have been analyzed to decipher the mechanism of the organic matter enrichment.The results show that the shales deposited in the western restricted intraplatform have much higher TOC contents(3.2%-19.8%,on average 11.0%)than those from the eastern basin(2.2%-10.2%,on average 4.5%).The paleoproductivity proxies(Ba,Ba/Al,P/Al)in the western restricted platform are much higher than those in the eastern basin.The trace element indicators such as V/Cr,Ni/Co,Mo-TOC and Mo_(EF)-U_(EF)suggest an anoxic environment across the basin,but a more restricted environment in the western intraplatform.The paleoproductivity rather than anoxic condition and hydrothermal activity are concluded to have resulted in the differentiation of the organic matter enrichment from the western intraplatform to eastern basin in the early Cambrian shales;the restricted environment was favorable for paleoproductivity and preservation of organic matter.
基金supported by the National Key R&D Program of China (Nos. 2021YFA1600401 and2021YFA1600400)National Natural Science Foundation of China (Nos. 11873058 and 12133004)supported by the National Natural Science Foundation of China (Nos.11988101 and 11833009)。
文摘Previous studies have identified two emission modes in PSR B1859+07: a normal mode that has three prominent components in the average profile, with the trailing one being the brightest, and an anomalous mode(i.e., the A mode) where emissions seem to be shifted to an earlier phase. Within the normal mode, further analysis has revealed the presence of two submodes, i.e., the cW mode and c B mode, where the central component can appear either weak or bright. As for the anomalous mode, a new bright component emerges in the advanced phase while the bright trailing component in the normal mode disappears. New observations of PSR B1859+07 using the Fivehundred-meter Aperture Spherical Radio Telescope(FAST) have revealed the existence of a previously unknown emission mode, dubbed the Af mode. In this mode, all emission components seen in the normal and anomalous modes are detected. Notably, the mean polarization profiles of both the A and Af modes exhibit a jump in the orthogonal polarization angle modesin the bright leading component. The polarization angles for the central component in the original normal mode follow two distinct orthogonal polarization modes in the A and Af modes respectively. The polarization angles for the trailing component show almost the same but a small systematic shift in the A and Af modes, roughly following the values for the c W and cB modes. Those polarization features of this newly detected emission mode imply that the anomalous mode A of PSR B1859+07 is not a result of “phase shift”or “swooshes” of normal components, but simply a result of the varying intensities of different profile components.Additionally, subpulse drifting has been detected in the leading component of the Af mode.
基金This project,as one of five key projects,is being carried out by using FAST,a Chinese national mega-science facility built and operated by the National Astronomical Observatories,Chinese Academy of Sciencessupported by the National Natural Science Foundation of China(NSFC,Nos.11988101 and 11833009)+5 种基金the Key Research Program of the Chinese Academy of Sciences(grant No.QYZDJ-SSWSLH021)supported by the Cultivation Project for the FAST scientific Payoff and Research Achievement of CAMS-CASsupported by NSFC No.12133004,partially supported by NSFC No.U1731120partially supported by the NSFC No.11873058,partially supported by NSFC No.U2031115partially supported by the National SKA program of China No.2020SKA0120200partially supported by the Guangzhou Science and Technology Project No.202102010466。
文摘We have carried out the Galactic Plane Pulsar Snapshot(GPPS)survey by using the Five-hundred-meter Aperture Spherical radio Telescope(FAST),the most sensitive systematic pulsar survey in the Galactic plane.In addition to more than 500 pulsars already discovered through normal periodical search,we report here the discovery of 76 new transient radio sources with sporadic strong pulses,detected by using the newly developed module for a sensitive single-pulse search.Their small DM values suggest that they all are Galactic rotating radio transients(RRATs).They show different properties in the follow-up observations.More radio pulses have been detected from 26 transient radio sources but no periods can be found due to a limited small number of pulses from all FAST observations.The followup observations show that 16 transient sources are newly identified as being the prototypes of RRATs with a period already determined from more detected sporadic pulses,and 10 sources are extremely nulling pulsars,and 24 sources are weak pulsars with sparse strong pulses.On the other hand,48 previously known RRATs have been detected by the FAST,either during verification observations for the GPPS survey or through targeted observations of applied normal FAST projects.Except for one RRAT with four pulses detected in a session of 5-minute observation and four RRATs with only one pulse detected in a session,sensitive FAST observations reveal that 43 RRATs are just generally weak pulsars with sporadic strong pulses or simply very nulling pulsars,so that the previously known RRATs always have an extreme emission state together with a normal hardly detectable weak emission state.This is echoed by the two normal pulsars J1938+2213 and J1946+1449 with occasional brightening pulses.Though strong pulses of RRATs are very outstanding in the energy distribution,their polarization angle variations follow the polarization angle curve of the averaged normal pulse profile,suggesting that the predominant sparse pulses of RRATs are emitted in the same region with the same geometry as normal weak pulsars.
