目的探索加味麻黄附子细辛汤治疗腰椎间盘突出症疗效优势人群和和使用禁忌,凸显六经辨证特色和优势。方法选取2019年3月~2020年3月就诊于上海市浦东新区中医医院骨伤门诊患者,采用队列研究分析将运用加味麻黄附子细辛汤结合中医综合治...目的探索加味麻黄附子细辛汤治疗腰椎间盘突出症疗效优势人群和和使用禁忌,凸显六经辨证特色和优势。方法选取2019年3月~2020年3月就诊于上海市浦东新区中医医院骨伤门诊患者,采用队列研究分析将运用加味麻黄附子细辛汤结合中医综合治疗的腰椎间盘突出症与单纯采用中医综合治疗的腰椎间盘突出症患者分为暴露组和对照组,比较两组患者临床疗效,并将暴露组根据性别、年龄、二十四节气、体质量指数(body mass index,BMI)等因素进一步分亚组比较,探索麻黄附子细辛汤疗效优势人群和使用禁忌。结果共收集204例患者,一般资料分析证实各项数据差异均有可比性。经统计分析,所有亚组均可改善腰椎间盘突出症症状;其中年龄>50岁、BMI<26.9 kg/m^(2)、病程<3年、轻中劳动强度、冬春季组为加味麻黄附子细辛汤的疗效优势人群;回归分析显示,患者年龄越大,加味麻黄附子细辛汤疗效越好;病程越长,加味麻黄附子细辛汤疗效越差;高血压具有双向影响机制。结论①加味麻黄附子细辛汤可改善太阳少阴合病腰椎间盘突出症患者的症状;②加味麻黄附子细辛汤具有特定的疗效优势人群,在临床中,应选择有相应特征的患者使用。展开更多
Background:To illustrate the research framework,overall knowledge structure,and development trends of Chinese medicine(CM)treatment for osteosarcoma(OS)by using a bibliometric analysis and newly developed visualizatio...Background:To illustrate the research framework,overall knowledge structure,and development trends of Chinese medicine(CM)treatment for osteosarcoma(OS)by using a bibliometric analysis and newly developed visualization tools.Methods:Research datasets were acquired from the Web of Science(WOS)database from January 1,1980 to September 30,2019.VOS viewer and Citespace software was used to analyze the data and generate visualization knowledge maps.Annual trends of publications,distribution of institutes,distribution of journals,citation and H-index status,co-authorship status,research hotspots and co-citation status were analyzed.Results:A total of 223 publications in the WOS database met the requirement.The number of published articles showed a rise but the citation frequency and the H-index of China were relatively low.The cooperation between the countries,institutes and authors were relatively weak.Most publications were basic researches.Most of the previous researches focused on basic mechanisms of CM in treating OS,and therapy and improvement of dosage form may become a frontier in this research field.Conclusions:Compared with other fields,the field of CM treatment for osteosarcome is still in infancy.The distribution of researches is imbalanced and cooperation between countries,institutions and authors remains to be strengthened.Furthermore,basic research occupies an absolute dominant position,and the exploration of the molecular mechanism of CM in preventing and treating OS may become a key point in the future.展开更多
文摘目的探索加味麻黄附子细辛汤治疗腰椎间盘突出症疗效优势人群和和使用禁忌,凸显六经辨证特色和优势。方法选取2019年3月~2020年3月就诊于上海市浦东新区中医医院骨伤门诊患者,采用队列研究分析将运用加味麻黄附子细辛汤结合中医综合治疗的腰椎间盘突出症与单纯采用中医综合治疗的腰椎间盘突出症患者分为暴露组和对照组,比较两组患者临床疗效,并将暴露组根据性别、年龄、二十四节气、体质量指数(body mass index,BMI)等因素进一步分亚组比较,探索麻黄附子细辛汤疗效优势人群和使用禁忌。结果共收集204例患者,一般资料分析证实各项数据差异均有可比性。经统计分析,所有亚组均可改善腰椎间盘突出症症状;其中年龄>50岁、BMI<26.9 kg/m^(2)、病程<3年、轻中劳动强度、冬春季组为加味麻黄附子细辛汤的疗效优势人群;回归分析显示,患者年龄越大,加味麻黄附子细辛汤疗效越好;病程越长,加味麻黄附子细辛汤疗效越差;高血压具有双向影响机制。结论①加味麻黄附子细辛汤可改善太阳少阴合病腰椎间盘突出症患者的症状;②加味麻黄附子细辛汤具有特定的疗效优势人群,在临床中,应选择有相应特征的患者使用。
基金Supported by the National Science Foundation of China(No.81704097)"Sailing Program"of the Shanghai Science and Technology Committee(No.19YF1449600)the"Yumiao Project"of Longhua Hospital affiliated to Shanghai University of Chinese Medicine(No.LYTD-60)。
文摘Background:To illustrate the research framework,overall knowledge structure,and development trends of Chinese medicine(CM)treatment for osteosarcoma(OS)by using a bibliometric analysis and newly developed visualization tools.Methods:Research datasets were acquired from the Web of Science(WOS)database from January 1,1980 to September 30,2019.VOS viewer and Citespace software was used to analyze the data and generate visualization knowledge maps.Annual trends of publications,distribution of institutes,distribution of journals,citation and H-index status,co-authorship status,research hotspots and co-citation status were analyzed.Results:A total of 223 publications in the WOS database met the requirement.The number of published articles showed a rise but the citation frequency and the H-index of China were relatively low.The cooperation between the countries,institutes and authors were relatively weak.Most publications were basic researches.Most of the previous researches focused on basic mechanisms of CM in treating OS,and therapy and improvement of dosage form may become a frontier in this research field.Conclusions:Compared with other fields,the field of CM treatment for osteosarcome is still in infancy.The distribution of researches is imbalanced and cooperation between countries,institutions and authors remains to be strengthened.Furthermore,basic research occupies an absolute dominant position,and the exploration of the molecular mechanism of CM in preventing and treating OS may become a key point in the future.
