Objective:To test the hypothesis thatβ-glucan enhances protective qi(PQi),an important Chinese medicine(CM)concept which stipulates that a protective force circulates throughout the body surface and works as the firs...Objective:To test the hypothesis thatβ-glucan enhances protective qi(PQi),an important Chinese medicine(CM)concept which stipulates that a protective force circulates throughout the body surface and works as the first line of defense against"external pernicious influences".Methods:A total of 138 participants with PQi deficiency(PQD)were randomized to receiveβ-glucan(200 mg daily)or placebo for 12 weeks.Participants’PQi status was assessed every 2 weeks via conventional diagnosis and a standardized protocol from which a PQD severity and risk score was derived.Indices of participants’immune and general health status were also monitored,including upper respiratory tract infection(URTI),saliva secretory Ig A(s Ig A),and self-reported measures of physical and mental health(PROMIS).Results:PQi status was not significantly different between theβ-glucan and placebo treatment groups at baseline but improved significantly in theβ-glucan(vs.placebo)group in a time-dependent manner.The intergroup differences[95%confidence interval(CI)]in severity score(scale:1-5),risk score(scale:0-1),and proportion of PQD participants(%)at finish line was 0.49(0.35-0.62),0.48(0.35-0.61),and 0.36(0.25-0.47),respectively.Additionally,β-glucan improved URTI symptom(scale:1-9)and PROMIS physical(scale:16.2-67.7)and mental(scale:21.2-67.6)scores by a magnitude(95%CI)of 1.0(0.21-1.86),5.7(2.33-9.07),and 3.0(-0.37-6.37),respectively,over placebo.Conclusions:β-Glucan ameliorates PQi in PQD individuals.By using stringent evidence-based methodologies,our study demonstrated that Western medicine-derived remedies,such asβ-glucan,can be employed to advance CM therapeutics.(Clinical Trial.Gov registry:NCT03782974)展开更多
By adopting mixed-ligand strategy,two Co(Ⅱ)coordination polymers,[Co(phda)(itmb)(H2O)2]n(1)and[Co(phda)(Hpytz)]n(2)(H2phda=1,2-phenylenediacetate,itmb=1-(imidazo-1-ly)-4-(1,2,4-triazol-1-yl methyl)benzene and Hpytz=3...By adopting mixed-ligand strategy,two Co(Ⅱ)coordination polymers,[Co(phda)(itmb)(H2O)2]n(1)and[Co(phda)(Hpytz)]n(2)(H2phda=1,2-phenylenediacetate,itmb=1-(imidazo-1-ly)-4-(1,2,4-triazol-1-yl methyl)benzene and Hpytz=3,5-di(4-pyridyl)-1,2,4-triazolate),were hydrothermally synthesized and then characterized by elemental analysis,IR spectroscopy,thermogravimetric analysis(TGA),powder X-ray diffraction(PXRD)and single-crystal X-ray diffraction.The single-crystal X-ray diffraction reveals that two complexes feature carboxylato-bridged binuclear subunits extended further by the nitrogen-rich coligands to form different structures.Complex 1 containing phda-bridged binuclear cobalt is developed by itmb coligand to 1D double-stranded chain,whereas complex 2 exhibits 2D open bilayers,which result from the ribbon-like carboxylate chains pillared Hpytz coligands.In addition,the magnetic susceptibilities of both compounds were measured over the temperature range of 3~300 K,and the data were analyzed well using Mag Saki software.The best fitting parameters wereκ=0.98,λ=-100 cm-1,?=588 cm-1 and J=0.6 cm-1 for complex 1 andκ=0.86,λ=-110 cm-1,?=756.8 cm-1 and J=-1.25 cm-1 for complex 2.The results indicate the existence of weaker ferromagnetic interaction for complex 1 and antiferromagnetic interaction for complex 2 between the metal centers in the dinuclear metal units.展开更多
基金Supported by USANA Health Science Inc.,the manufacturer of Proglucamune■。
文摘Objective:To test the hypothesis thatβ-glucan enhances protective qi(PQi),an important Chinese medicine(CM)concept which stipulates that a protective force circulates throughout the body surface and works as the first line of defense against"external pernicious influences".Methods:A total of 138 participants with PQi deficiency(PQD)were randomized to receiveβ-glucan(200 mg daily)or placebo for 12 weeks.Participants’PQi status was assessed every 2 weeks via conventional diagnosis and a standardized protocol from which a PQD severity and risk score was derived.Indices of participants’immune and general health status were also monitored,including upper respiratory tract infection(URTI),saliva secretory Ig A(s Ig A),and self-reported measures of physical and mental health(PROMIS).Results:PQi status was not significantly different between theβ-glucan and placebo treatment groups at baseline but improved significantly in theβ-glucan(vs.placebo)group in a time-dependent manner.The intergroup differences[95%confidence interval(CI)]in severity score(scale:1-5),risk score(scale:0-1),and proportion of PQD participants(%)at finish line was 0.49(0.35-0.62),0.48(0.35-0.61),and 0.36(0.25-0.47),respectively.Additionally,β-glucan improved URTI symptom(scale:1-9)and PROMIS physical(scale:16.2-67.7)and mental(scale:21.2-67.6)scores by a magnitude(95%CI)of 1.0(0.21-1.86),5.7(2.33-9.07),and 3.0(-0.37-6.37),respectively,over placebo.Conclusions:β-Glucan ameliorates PQi in PQD individuals.By using stringent evidence-based methodologies,our study demonstrated that Western medicine-derived remedies,such asβ-glucan,can be employed to advance CM therapeutics.(Clinical Trial.Gov registry:NCT03782974)
基金supported by the National Natural Science Foundation of China(No.21571093)Colleges and Universities Key Scientific Research Project of Henan Province(No.18B150016)。
文摘By adopting mixed-ligand strategy,two Co(Ⅱ)coordination polymers,[Co(phda)(itmb)(H2O)2]n(1)and[Co(phda)(Hpytz)]n(2)(H2phda=1,2-phenylenediacetate,itmb=1-(imidazo-1-ly)-4-(1,2,4-triazol-1-yl methyl)benzene and Hpytz=3,5-di(4-pyridyl)-1,2,4-triazolate),were hydrothermally synthesized and then characterized by elemental analysis,IR spectroscopy,thermogravimetric analysis(TGA),powder X-ray diffraction(PXRD)and single-crystal X-ray diffraction.The single-crystal X-ray diffraction reveals that two complexes feature carboxylato-bridged binuclear subunits extended further by the nitrogen-rich coligands to form different structures.Complex 1 containing phda-bridged binuclear cobalt is developed by itmb coligand to 1D double-stranded chain,whereas complex 2 exhibits 2D open bilayers,which result from the ribbon-like carboxylate chains pillared Hpytz coligands.In addition,the magnetic susceptibilities of both compounds were measured over the temperature range of 3~300 K,and the data were analyzed well using Mag Saki software.The best fitting parameters wereκ=0.98,λ=-100 cm-1,?=588 cm-1 and J=0.6 cm-1 for complex 1 andκ=0.86,λ=-110 cm-1,?=756.8 cm-1 and J=-1.25 cm-1 for complex 2.The results indicate the existence of weaker ferromagnetic interaction for complex 1 and antiferromagnetic interaction for complex 2 between the metal centers in the dinuclear metal units.
