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A PCR-based Rapid Neutralization Assay for GⅡ.4 Norovirus Infection in HIEC6 Cell Culture
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作者 FAN Yi Sun LIU Cheng +5 位作者 ZHU Hui Juan DING Yi ZENG Wan Jie YIN Xu Fang DING Shuang Shuang ZHANG Jun 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2015年第3期219-221,共3页
Because of limited viral replication and lack of cytopathic effect in cell culture,a new PCR-based rapid seroneutralization assay for detection of GII.4norovirus neutralized antibodies was developed with serum samples... Because of limited viral replication and lack of cytopathic effect in cell culture,a new PCR-based rapid seroneutralization assay for detection of GII.4norovirus neutralized antibodies was developed with serum samples from acute-phase patients,convalescent-phase patients and healthy controls.According to this study,neutralizing antibodies were detected in 100% ofconvalescent-phase sera, and in 2.5% of healthy controls sera. However, all of the acute-phase serum samples could not neutralize virus efficiently. Compared to the results from ELISA (96.2% at sensitivity and 80% at specificity), the present in vitro neutralization assay is more specific and more sensitive. 展开更多
关键词 Infection replication diluted stored titer Jiangsu processed capture approval genomic
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