Spatial heterogeneity or“patchiness”of plankton distributions in the ocean has always been an attractive and challenging scientific issue to oceanographers.We focused on the accumulation and dynamic mechanism of the...Spatial heterogeneity or“patchiness”of plankton distributions in the ocean has always been an attractive and challenging scientific issue to oceanographers.We focused on the accumulation and dynamic mechanism of the Acetes chinensis in the Lianyungang nearshore licensed fishing area.The Lagrangian frame approaches including the Lagrangian coherent structures theory,Lagrangian residual current,and Lagrangian particle-tracking model were applied to find the transport pathways and aggregation characteristics of Acetes chinensis.There exist some material transport pathways for Acetes chinensis passing through the licensed fishing area,and Acetes chinensis is easy to accumulate in the licensed fishing area.The main mechanism forming this distribution pattern is the local circulation induced by the nonlinear interaction of topography and tidal flow.Both the Lagrangian coherent structure analysis and the particle trajectory tracking indicate that Acetes chinensis in the licensed fishing area come from the nearshore estuary.This work contributed to the adjustment of licensed fishing area and the efficient utilization of fishery resources.展开更多
Wideband spectrum sensing with a high-speed analog-digital converter(ADC) presents a challenge for practical systems.The Nyquist folding receiver(NYFR) is a promising scheme for achieving cost-effective real-time spec...Wideband spectrum sensing with a high-speed analog-digital converter(ADC) presents a challenge for practical systems.The Nyquist folding receiver(NYFR) is a promising scheme for achieving cost-effective real-time spectrum sensing,which is subject to the complexity of processing the modulated outputs.In this case,a multipath NYFR architecture with a step-sampling rate for the different paths is proposed.The different numbers of digital channels for each path are designed based on the Chinese remainder theorem(CRT).Then,the detectable frequency range is divided into multiple frequency grids,and the Nyquist zone(NZ) of the input can be obtained by sensing these grids.Thus,high-precision parameter estimation is performed by utilizing the NYFR characteristics.Compared with the existing methods,the scheme proposed in this paper overcomes the challenge of NZ estimation,information damage,many computations,low accuracy,and high false alarm probability.Comparative simulation experiments verify the effectiveness of the proposed architecture in this paper.展开更多
Osteosarcoma is a very serious primary bone cancer with a high death rate and a dismal prognosis.Since there is no permanent therapy for this condition,it is necessary to develop a cure.Therefore,this investigation wa...Osteosarcoma is a very serious primary bone cancer with a high death rate and a dismal prognosis.Since there is no permanent therapy for this condition,it is necessary to develop a cure.Therefore,this investigation was carried out to assess the impacts and biological functions of hydroxysafflor yellow A(HYSA)in osteosarcoma cell lines(MG63).In this investigational study,MG63 cells were utilized.Microarray experiments,quantitative polymerase chain reaction(qPCR),immunofluorescent staining,extracellular acidification rate(ECAR),oxygen consumption rate(OCR),glucose consumption,lactate production,and ATP levels,proliferation assay,5-Ethynyl-2′-deoxyuridine(EDU)staining,and Western blot were performed.In MG63 cells,HYSA lowered cell proliferation and metastasis rates,suppressed EDU cell number,and enhanced caspase-3/9 activity levels.HYSA reduced the Warburg effect and induced ferroptosis(FPT)in MG63 cells.Inhibiting ferroptosis diminished HYSA’s anti-cancer activities in MG63 cells.The stimulation of the HIF-1α/SLC7A11 pathway decreased HYSA’s anti-cancer activities in MG63 cells.HIF-1αis one target spot for HYSA in a model of osteosarcoma cancer(OC).HYSA altered HIF-1α’s thermophoretic activity;following binding with HYSA,HIF-1α’s melting point increased from~55°C to~60°C.HYSA significantly enhanced the thermal stability of exogenous WT HIF-1αwhile not affecting Mut HIF-1α,suggesting that ARG-311,GLY-312,GLN-347,and GLN-387 may be involved in the interaction between HIF-1αand HYSA.Conclusively,our study revealed that HYSA induced FPT and reduced the Warburg effect of OC through mitochondrial damage by HIF-1α/HK2/SLC7A11 pathway.HYSA is a possible therapeutic option for OC or other cancers.展开更多
Carbon neutrality(or climate neutrality)has been a global consensus,and international experience exchange is essential.Given the differences in the degree of social development,resource endowment and technological lev...Carbon neutrality(or climate neutrality)has been a global consensus,and international experience exchange is essential.Given the differences in the degree of social development,resource endowment and technological level,each country should build a carbon-neutral plan based on its national conditions.Compared with other major developed countries(e.g.,Germany,the United States and Japan),China's carbon neutrality has much bigger challenges,including a heavy and time-pressured carbon reduction task and the current energy structure that is over-dependent on fossil fuels.Here we provide a comprehensive review of the status and prospects of the key technologies for low-carbon,near-zero carbon,and negative carbon emissions.Technological innovations associated with coal,oil-gas and hydrogen industries and their future potential in reducing carbon emissions are particularly explained and assessed.Based on integrated analysis of international experience from the world's major developed countries,in-depth knowledge of the current and future technologies,and China's energy and ecological resources potential,five lessons for the implementation of China's carbon neutrality are proposed:(1)transformation of energy production pattern from a coal-dominated pattern to a diversified renewable energy pattern;(2)renewable power-to-X and large-scale underground energy storage;(3)integration of green hydrogen production,storage,transport and utilization;(4)construction of clean energy systems based on smart sector coupling(ENSYSCO);(5)improvement of ecosystem carbon sinks both in nationwide forest land and potential desert in Northwest China.This paper provides an international perspective for a better understanding of the challenges and opportunities of carbon neutrality in China,and can serve as a theoretical foundation for medium-long term carbon neutral policy formulation.展开更多
Textile electronics have become an indispensable part of wearable applications because of their large flexibility,light-weight,comfort and electronic functionality upon the merge of textiles and microelectronics.As a ...Textile electronics have become an indispensable part of wearable applications because of their large flexibility,light-weight,comfort and electronic functionality upon the merge of textiles and microelectronics.As a result,the fabrication of functional fibrous materials and the integration of textile electronic devices have attracted increasing interest in the wearable electronic community.Challenges are encountered in the development of textile electronics in a way that is electrically reliable and durable,without compromising on the deformability and comfort of a garment,including processing multiple materials with great mismatches in mechanical,thermal,and electrical properties and assembling various structures with the disparity in dimensional scales and surface roughness.Equal challenges lie in high-quality and cost-effective processes facilitated by high-level digital technology enabled design and manufacturing methods.This work reviews the manufacturing of textile-shaped electronics via the processing of functional fibrous materials from the perspective of hierarchical architectures,and discusses the heterogeneous integration of microelectronics into normal textiles upon the fabric circuit board and adapted electrical connections,broadly covering both conventional and advanced textile electronic production processes.We summarize the applications and obstacles of textile electronics explored so far in sensors,actuators,thermal management,energy fields,and displays.Finally,the main conclusions and outlook are provided while the remaining challenges of the fabrication and application of textile electronics are emphasized.展开更多
As an emerging waterless fracturing technology,supercritical carbon dioxide(SC-CO_(2))fracturing can reduce reservoir damage and dependence on water resources,and can also promote the reservoir stimulation and geologi...As an emerging waterless fracturing technology,supercritical carbon dioxide(SC-CO_(2))fracturing can reduce reservoir damage and dependence on water resources,and can also promote the reservoir stimulation and geological storage of carbon dioxide(CO_(2)).It is vital to figure out the laws in SC-CO_(2)fracturing for the large-scale field implementation of this technology.This paper reviews the numerical simulations of wellbore flow and heat transfer,fracture initiation and propagation,and proppant transport in SC-CO_(2)fracturing,including the numerical approaches and the obtained findings.It shows that the variations of wellbore temperature and pressure are complex and strongly transient.The wellhead pressure can be reduced by tubing and annulus co-injection or adding drag reducers into the fracturing fluid.Increasing the temperature of CO_(2)with wellhead heating can promote CO_(2)to reach the well bottom in the supercritical state.Compared with hydraulic fracturing,SC-CO_(2)fracturing has a lower fracture initiation pressure and can form a more complex fracture network,but the fracture width is narrower.The technology of SC-CO_(2)fracturing followed by thickened SC-CO_(2)fracturing,which combines with high injection rates and ultra-light proppants,can improve the placement effect of proppants while improving the complexity and width of fractures.The follow-up research is required to get a deeper insight into the SC-CO_(2)fracturing mechanisms and develop cost-effective drag reducers,thickeners,and ultra-light proppants.This paper can guide further research and promote the field application of SC-CO_(2)fracturing technology.展开更多
Safety plays an important role in determining the applicability of energetic compounds,and the bond dissociation enthalpy(BDE)of the“trigger bond”X-NO_(2) provides useful information to evaluate various safety prope...Safety plays an important role in determining the applicability of energetic compounds,and the bond dissociation enthalpy(BDE)of the“trigger bond”X-NO_(2) provides useful information to evaluate various safety properties.Accurate and rapid calculation of the BDE of X-NO_(2) is of great significance to perform the high-throughput design of energetic compounds,which becomes an increasingly popular means of materials design.We conduct a benchmark BDE calculation for 44 X-NO_(2) samples extracted from the iBond database,with the accuracies of 55 quantum chemistry calculation levels evaluated by the experimentally measured values.Only four levels have the global mean-absolute deviation(MAD)less than 10 kJ/mol,but no calculation level can achieve that all the local MADs of each category less than 10 kJ/mol.We propose a simple correction strategy for the original calculation deviations,and apply it to 30 calculation levels screened out through a series of accuracy assessments and obtain the corrected MAD<6 kJ/mol in some cases.We define a normalized time-cost(NTC)to evaluate the time-cost of each calculation level,and confirm that PBE0-D3/6-31G^(**)(MAD=6.4 kJ/mol,NTC?0.8)works the best for most cases,followed by M062X/6-31g^(**),M062X/6-311g^(**)andɷB97XD/6-311g^(**),based on an insight into the accuracy-cost trade.The present work provides an accurate and fast solution for calculating XNO_(2) BDE via quantum chemical methods,and is expected to be beneficial to enhance the safety prediction efficiency of energetic compounds.展开更多
In this study,we present characteristics of post-sunset GHz scintillation occurrence and their correlations with ionospheric parameters derived from ionosonde observations in high solar activity years(2012−2013)of sol...In this study,we present characteristics of post-sunset GHz scintillation occurrence and their correlations with ionospheric parameters derived from ionosonde observations in high solar activity years(2012−2013)of solar cycle 24 at Sanya(18.3°N,109.6°E;dip lat.:12.8°N),China.The analyzed data include the F_(2)-layer’s critical frequency(foF_(2)),peak height(h_(m)F_(2)),and minimum virtual height(h’F),as well as the scale height around the F_(2)-layer peak(H_(m)),and virtual height(h’F_(5))and true height(hF_(5))measured at 5 MHz.We have investigated relationships between the equinoctial asymmetry of these scintillations and these ionospheric parameters.In addition,we calculate the growth rates of Rayleigh−Taylor instability on the basis of the ionosonde measurements and theoretical models,respectively.We find that the equinoctial asymmetry of scintillation onset time is associated with the scale length of the vertical electron density gradient(L),which has been shown to affect the growth of Rayleigh−Taylor instability at the bottom of the F-layer.The seasonal variations of foF_(2),H_(m)and scale length of vertical electron density gradient appear to cause the seasonal variations of scintillation occurrence;the equinoctial asymmetry of scintillation occurrence rate over low latitudes appears to be related to background electron density and vertical drifts in the F-layer around time of sunset.Further study is required to explain the observed correlational weakness in low latitudes between scintillation strength,represented by the daily maximum S4,and daily maximum values of foF_(2),h_(m)F_(2),h’F,H_(m),and also the drifts.展开更多
[Objectives]This study was conducted to evaluate the effects of carbon nanomaterials on soil ecosystem and explore the ecological risks of environmental exposure of carbon nanomaterials. [Methods] The effects of carbo...[Objectives]This study was conducted to evaluate the effects of carbon nanomaterials on soil ecosystem and explore the ecological risks of environmental exposure of carbon nanomaterials. [Methods] The effects of carbon nanomaterials on soil enzyme activity was studied by adding graphene, graphene oxide and carbon nanotubes to turfgrass soil. [Results] Compared with the control(CK), the activity of soil protease, sucrase, alkaline phosphatase and catalase was not significantly affected by carbon nanomaterials. Under the treatment of carbon nanotubes, urease activity was significantly lower than that of graphene and graphene oxide, and dehydrogenase activity was significantly lower than that of the CK, graphene and graphene oxide. [Conclusions] This study provides a theoretical basis for the safe application of carbon nanomaterials.展开更多
Benign prostatic hyperplasia (BPH) is one of the common diseases in middle-aged and elderly men, and its clinical symptoms include storage symptoms, voiding symptoms and post-urination symptoms. Surgery is an importan...Benign prostatic hyperplasia (BPH) is one of the common diseases in middle-aged and elderly men, and its clinical symptoms include storage symptoms, voiding symptoms and post-urination symptoms. Surgery is an important treatment method for benign prostatic hyperplasia. It is suitable for BPH patients with moderate to severe LUTS (Lower Urinary Tract Symptoms) and has significantly affected the quality of life. The surgical methods include transurethral resection of the prostate and transurethral holmium laser enucleation of the prostate. While offering a high chance of cure, it also brings some complications, including postoperative urinary incontinence. This article mainly reviews the urinary incontinence after transurethral prostate surgery in recent years and analyzes its risk factors, and summarizes the experience for further prediction and reduction of the incidence of urinary incontinence.展开更多
Objective: This study aimed to construct a bladder cancer prognostic model using bioinformatics to predict the survival of bladder cancer patients. Methods: RNA sequences and corresponding clinical data were downloade...Objective: This study aimed to construct a bladder cancer prognostic model using bioinformatics to predict the survival of bladder cancer patients. Methods: RNA sequences and corresponding clinical data were downloaded from The Cancer Genome Atlas (TCGA) database, and the differentially expressed RNA-binding proteins (RBPs) were screened for analysis using the limma software package. Then, GO enrichment analysis and KEGG pathway analysis were performed on these differentially expressed RNA-binding proteins, and a PPI network was constructed. Finally, a risk model was constructed based on the screened central RBP, and a Kaplan-Meier survival curve was drawn to evaluate the prognostic value of central RBP and predict the prognosis of bladder Cancer(BLCA) patients with this model. Finally, the human protein atlas (HPA) online database (http://www.proteinatlas.org/) was used to further detect the differential expression of central hub RBP at the protein level between tumor tissue and normal tissue. Results: The bladder cancer prognostic model constructed with these six central RBPs had good sensitivity and specificity in predicting the prognosis of bladder cancer patients. Conclusion: This study explored the genes and regulatory networks of bladder cancer prognosis-related RNA-binding protein and bladder cancer, and constructed a bladder cancer prognosis model, which provides a theoretical basis for the development of new bladder cancer prognosis biomarkers in the future.展开更多
基金the National Natural Science Foundation of China(No.31802297)。
文摘Spatial heterogeneity or“patchiness”of plankton distributions in the ocean has always been an attractive and challenging scientific issue to oceanographers.We focused on the accumulation and dynamic mechanism of the Acetes chinensis in the Lianyungang nearshore licensed fishing area.The Lagrangian frame approaches including the Lagrangian coherent structures theory,Lagrangian residual current,and Lagrangian particle-tracking model were applied to find the transport pathways and aggregation characteristics of Acetes chinensis.There exist some material transport pathways for Acetes chinensis passing through the licensed fishing area,and Acetes chinensis is easy to accumulate in the licensed fishing area.The main mechanism forming this distribution pattern is the local circulation induced by the nonlinear interaction of topography and tidal flow.Both the Lagrangian coherent structure analysis and the particle trajectory tracking indicate that Acetes chinensis in the licensed fishing area come from the nearshore estuary.This work contributed to the adjustment of licensed fishing area and the efficient utilization of fishery resources.
基金supported by the Key Projects of the 2022 National Defense Science and Technology Foundation Strengthening Plan 173 (Grant No.2022-173ZD-010)the Equipment PreResearch Foundation of The State Key Laboratory (Grant No.6142101200204)。
文摘Wideband spectrum sensing with a high-speed analog-digital converter(ADC) presents a challenge for practical systems.The Nyquist folding receiver(NYFR) is a promising scheme for achieving cost-effective real-time spectrum sensing,which is subject to the complexity of processing the modulated outputs.In this case,a multipath NYFR architecture with a step-sampling rate for the different paths is proposed.The different numbers of digital channels for each path are designed based on the Chinese remainder theorem(CRT).Then,the detectable frequency range is divided into multiple frequency grids,and the Nyquist zone(NZ) of the input can be obtained by sensing these grids.Thus,high-precision parameter estimation is performed by utilizing the NYFR characteristics.Compared with the existing methods,the scheme proposed in this paper overcomes the challenge of NZ estimation,information damage,many computations,low accuracy,and high false alarm probability.Comparative simulation experiments verify the effectiveness of the proposed architecture in this paper.
文摘Osteosarcoma is a very serious primary bone cancer with a high death rate and a dismal prognosis.Since there is no permanent therapy for this condition,it is necessary to develop a cure.Therefore,this investigation was carried out to assess the impacts and biological functions of hydroxysafflor yellow A(HYSA)in osteosarcoma cell lines(MG63).In this investigational study,MG63 cells were utilized.Microarray experiments,quantitative polymerase chain reaction(qPCR),immunofluorescent staining,extracellular acidification rate(ECAR),oxygen consumption rate(OCR),glucose consumption,lactate production,and ATP levels,proliferation assay,5-Ethynyl-2′-deoxyuridine(EDU)staining,and Western blot were performed.In MG63 cells,HYSA lowered cell proliferation and metastasis rates,suppressed EDU cell number,and enhanced caspase-3/9 activity levels.HYSA reduced the Warburg effect and induced ferroptosis(FPT)in MG63 cells.Inhibiting ferroptosis diminished HYSA’s anti-cancer activities in MG63 cells.The stimulation of the HIF-1α/SLC7A11 pathway decreased HYSA’s anti-cancer activities in MG63 cells.HIF-1αis one target spot for HYSA in a model of osteosarcoma cancer(OC).HYSA altered HIF-1α’s thermophoretic activity;following binding with HYSA,HIF-1α’s melting point increased from~55°C to~60°C.HYSA significantly enhanced the thermal stability of exogenous WT HIF-1αwhile not affecting Mut HIF-1α,suggesting that ARG-311,GLY-312,GLN-347,and GLN-387 may be involved in the interaction between HIF-1αand HYSA.Conclusively,our study revealed that HYSA induced FPT and reduced the Warburg effect of OC through mitochondrial damage by HIF-1α/HK2/SLC7A11 pathway.HYSA is a possible therapeutic option for OC or other cancers.
基金supported by the Henan Institute for Chinese Development Strategy of Engineering&Technology(Grant No.2022HENZDA02)by the Science&Technology Department of Sichuan Province Project(Grant No.2021YFH0010).
文摘Carbon neutrality(or climate neutrality)has been a global consensus,and international experience exchange is essential.Given the differences in the degree of social development,resource endowment and technological level,each country should build a carbon-neutral plan based on its national conditions.Compared with other major developed countries(e.g.,Germany,the United States and Japan),China's carbon neutrality has much bigger challenges,including a heavy and time-pressured carbon reduction task and the current energy structure that is over-dependent on fossil fuels.Here we provide a comprehensive review of the status and prospects of the key technologies for low-carbon,near-zero carbon,and negative carbon emissions.Technological innovations associated with coal,oil-gas and hydrogen industries and their future potential in reducing carbon emissions are particularly explained and assessed.Based on integrated analysis of international experience from the world's major developed countries,in-depth knowledge of the current and future technologies,and China's energy and ecological resources potential,five lessons for the implementation of China's carbon neutrality are proposed:(1)transformation of energy production pattern from a coal-dominated pattern to a diversified renewable energy pattern;(2)renewable power-to-X and large-scale underground energy storage;(3)integration of green hydrogen production,storage,transport and utilization;(4)construction of clean energy systems based on smart sector coupling(ENSYSCO);(5)improvement of ecosystem carbon sinks both in nationwide forest land and potential desert in Northwest China.This paper provides an international perspective for a better understanding of the challenges and opportunities of carbon neutrality in China,and can serve as a theoretical foundation for medium-long term carbon neutral policy formulation.
基金funding support from Research Grants Council, Hong Kong (Nos. 15201922E, 15203421E, 15202020E, 15201419E)Innovation and Technology Commission (ITC) of Hong Kong SAR Government (No. ITP/031/21TP)+2 种基金postgraduate scholarships from the same sourcessupported by the Distinguished Postdoctoral Fellowship from Hong Kong Polytechnic Universitysupported by ITC’s Postdoctoral Fellowship
文摘Textile electronics have become an indispensable part of wearable applications because of their large flexibility,light-weight,comfort and electronic functionality upon the merge of textiles and microelectronics.As a result,the fabrication of functional fibrous materials and the integration of textile electronic devices have attracted increasing interest in the wearable electronic community.Challenges are encountered in the development of textile electronics in a way that is electrically reliable and durable,without compromising on the deformability and comfort of a garment,including processing multiple materials with great mismatches in mechanical,thermal,and electrical properties and assembling various structures with the disparity in dimensional scales and surface roughness.Equal challenges lie in high-quality and cost-effective processes facilitated by high-level digital technology enabled design and manufacturing methods.This work reviews the manufacturing of textile-shaped electronics via the processing of functional fibrous materials from the perspective of hierarchical architectures,and discusses the heterogeneous integration of microelectronics into normal textiles upon the fabric circuit board and adapted electrical connections,broadly covering both conventional and advanced textile electronic production processes.We summarize the applications and obstacles of textile electronics explored so far in sensors,actuators,thermal management,energy fields,and displays.Finally,the main conclusions and outlook are provided while the remaining challenges of the fabrication and application of textile electronics are emphasized.
基金funded by the Henan Institute for Chinese Development Strategy of Engineering&Technology(Grant No.2022HENZDA02)the China Scholarship Council(No.202208080058).
文摘As an emerging waterless fracturing technology,supercritical carbon dioxide(SC-CO_(2))fracturing can reduce reservoir damage and dependence on water resources,and can also promote the reservoir stimulation and geological storage of carbon dioxide(CO_(2)).It is vital to figure out the laws in SC-CO_(2)fracturing for the large-scale field implementation of this technology.This paper reviews the numerical simulations of wellbore flow and heat transfer,fracture initiation and propagation,and proppant transport in SC-CO_(2)fracturing,including the numerical approaches and the obtained findings.It shows that the variations of wellbore temperature and pressure are complex and strongly transient.The wellhead pressure can be reduced by tubing and annulus co-injection or adding drag reducers into the fracturing fluid.Increasing the temperature of CO_(2)with wellhead heating can promote CO_(2)to reach the well bottom in the supercritical state.Compared with hydraulic fracturing,SC-CO_(2)fracturing has a lower fracture initiation pressure and can form a more complex fracture network,but the fracture width is narrower.The technology of SC-CO_(2)fracturing followed by thickened SC-CO_(2)fracturing,which combines with high injection rates and ultra-light proppants,can improve the placement effect of proppants while improving the complexity and width of fractures.The follow-up research is required to get a deeper insight into the SC-CO_(2)fracturing mechanisms and develop cost-effective drag reducers,thickeners,and ultra-light proppants.This paper can guide further research and promote the field application of SC-CO_(2)fracturing technology.
基金the support of the Science Challenge Project(TZ-2018004)。
文摘Safety plays an important role in determining the applicability of energetic compounds,and the bond dissociation enthalpy(BDE)of the“trigger bond”X-NO_(2) provides useful information to evaluate various safety properties.Accurate and rapid calculation of the BDE of X-NO_(2) is of great significance to perform the high-throughput design of energetic compounds,which becomes an increasingly popular means of materials design.We conduct a benchmark BDE calculation for 44 X-NO_(2) samples extracted from the iBond database,with the accuracies of 55 quantum chemistry calculation levels evaluated by the experimentally measured values.Only four levels have the global mean-absolute deviation(MAD)less than 10 kJ/mol,but no calculation level can achieve that all the local MADs of each category less than 10 kJ/mol.We propose a simple correction strategy for the original calculation deviations,and apply it to 30 calculation levels screened out through a series of accuracy assessments and obtain the corrected MAD<6 kJ/mol in some cases.We define a normalized time-cost(NTC)to evaluate the time-cost of each calculation level,and confirm that PBE0-D3/6-31G^(**)(MAD=6.4 kJ/mol,NTC?0.8)works the best for most cases,followed by M062X/6-31g^(**),M062X/6-311g^(**)andɷB97XD/6-311g^(**),based on an insight into the accuracy-cost trade.The present work provides an accurate and fast solution for calculating XNO_(2) BDE via quantum chemical methods,and is expected to be beneficial to enhance the safety prediction efficiency of energetic compounds.
基金supported by the Fundamental Research Funds for the Central Universities,South-Central MinZu University(Grant Number:CPT22019).
文摘In this study,we present characteristics of post-sunset GHz scintillation occurrence and their correlations with ionospheric parameters derived from ionosonde observations in high solar activity years(2012−2013)of solar cycle 24 at Sanya(18.3°N,109.6°E;dip lat.:12.8°N),China.The analyzed data include the F_(2)-layer’s critical frequency(foF_(2)),peak height(h_(m)F_(2)),and minimum virtual height(h’F),as well as the scale height around the F_(2)-layer peak(H_(m)),and virtual height(h’F_(5))and true height(hF_(5))measured at 5 MHz.We have investigated relationships between the equinoctial asymmetry of these scintillations and these ionospheric parameters.In addition,we calculate the growth rates of Rayleigh−Taylor instability on the basis of the ionosonde measurements and theoretical models,respectively.We find that the equinoctial asymmetry of scintillation onset time is associated with the scale length of the vertical electron density gradient(L),which has been shown to affect the growth of Rayleigh−Taylor instability at the bottom of the F-layer.The seasonal variations of foF_(2),H_(m)and scale length of vertical electron density gradient appear to cause the seasonal variations of scintillation occurrence;the equinoctial asymmetry of scintillation occurrence rate over low latitudes appears to be related to background electron density and vertical drifts in the F-layer around time of sunset.Further study is required to explain the observed correlational weakness in low latitudes between scintillation strength,represented by the daily maximum S4,and daily maximum values of foF_(2),h_(m)F_(2),h’F,H_(m),and also the drifts.
基金Supported by National Natural Science Foundation of China (31870484)。
文摘[Objectives]This study was conducted to evaluate the effects of carbon nanomaterials on soil ecosystem and explore the ecological risks of environmental exposure of carbon nanomaterials. [Methods] The effects of carbon nanomaterials on soil enzyme activity was studied by adding graphene, graphene oxide and carbon nanotubes to turfgrass soil. [Results] Compared with the control(CK), the activity of soil protease, sucrase, alkaline phosphatase and catalase was not significantly affected by carbon nanomaterials. Under the treatment of carbon nanotubes, urease activity was significantly lower than that of graphene and graphene oxide, and dehydrogenase activity was significantly lower than that of the CK, graphene and graphene oxide. [Conclusions] This study provides a theoretical basis for the safe application of carbon nanomaterials.
文摘Benign prostatic hyperplasia (BPH) is one of the common diseases in middle-aged and elderly men, and its clinical symptoms include storage symptoms, voiding symptoms and post-urination symptoms. Surgery is an important treatment method for benign prostatic hyperplasia. It is suitable for BPH patients with moderate to severe LUTS (Lower Urinary Tract Symptoms) and has significantly affected the quality of life. The surgical methods include transurethral resection of the prostate and transurethral holmium laser enucleation of the prostate. While offering a high chance of cure, it also brings some complications, including postoperative urinary incontinence. This article mainly reviews the urinary incontinence after transurethral prostate surgery in recent years and analyzes its risk factors, and summarizes the experience for further prediction and reduction of the incidence of urinary incontinence.
文摘Objective: This study aimed to construct a bladder cancer prognostic model using bioinformatics to predict the survival of bladder cancer patients. Methods: RNA sequences and corresponding clinical data were downloaded from The Cancer Genome Atlas (TCGA) database, and the differentially expressed RNA-binding proteins (RBPs) were screened for analysis using the limma software package. Then, GO enrichment analysis and KEGG pathway analysis were performed on these differentially expressed RNA-binding proteins, and a PPI network was constructed. Finally, a risk model was constructed based on the screened central RBP, and a Kaplan-Meier survival curve was drawn to evaluate the prognostic value of central RBP and predict the prognosis of bladder Cancer(BLCA) patients with this model. Finally, the human protein atlas (HPA) online database (http://www.proteinatlas.org/) was used to further detect the differential expression of central hub RBP at the protein level between tumor tissue and normal tissue. Results: The bladder cancer prognostic model constructed with these six central RBPs had good sensitivity and specificity in predicting the prognosis of bladder cancer patients. Conclusion: This study explored the genes and regulatory networks of bladder cancer prognosis-related RNA-binding protein and bladder cancer, and constructed a bladder cancer prognosis model, which provides a theoretical basis for the development of new bladder cancer prognosis biomarkers in the future.
