Role of necroptosis in spinal cord injury and its therapeutic implications

Spinal cord injury(SCI),a complex neurological disorder,triggers a series of devastating neuropathological events such as ischemia,oxidative stress,inflammatory events,neuronal apoptosis,and motor dysfunction.However,the classical necrosome,which consists of receptor-interacting protein(RIP)1,RIP3,and mixed-lineage kinase domain-like protein,is believed to control a novel type of programmed cell death called necroptosis,through tumour necrosis factor-alpha/tumour necrosis factor receptor-1 signalling or other stimuli.Several studies reported that necroptosis plays an important role in neural cell damage,release of intracellular pro-inflammatory factors,lysosomal dysfunction and endoplasmic reticulum stress.Recent research indicates that necroptosis is crucial to the pathophysiology of a number of neurological disorders and SCIs.In our review,we summarize the potential role of programmed cell death regulated by necroptosis in SCI based on its molecular and pathophysiological mechanisms.We also summarize the targets of several necroptosis pathways,which provide a more reliable reference for the treatment of SCI.

Ecosystem Services Evaluation of Karst New Urban Areas Based on Net Primary Productivity of Guanshanhu District, Guiyang, Guizhou Province, China

Net Primary Productivity (NPP) is the basis of the material and energy transport calculation in ecosystem studies. NPP directly reflects the production capacity of plant communities under natural conditions. Ecosystem services are hot topics in the field of ecology. Many studies calculate ecosystem service value based on NPP. Taking Guanshanhu District of Guiyang City, Guizhou Province as the research object, using TM, ETM+, Gaofen2 and MOD17A3HGF.006 as data sources, this paper analyzed the change of ecosystem service value based on NPP in 2000, 2010 and 2020. The results showed that the area of forest ecosystem increased during 2000-2010 and decreased during 2010-2020. The artificial surface grew rapidly from 1146.82 hm2 to 7544.29 hm2 during 2000-2020. The farmland ecosystem decreased from 13308.29 hm2 to 6342.33 hm2 during 2000-2020. With the dynamic changes in ecosystem spatial distribution and component structure, the total NPP in 2000, 2010 and 2020 was 12.58 × 104 t, 11.90 × 104 t and 11.78 × 104 t, respectively, showing a decreasing trend. The total value of natural and semi-natural ecosystems services based on NPP showed an increasing trend, which was ￥ 6.938 × 108 in 2000, ￥ 8.052 × 108 in 2010 and ￥ 10.306 × 108 in 2020 respectively. The ecosystem contributed the most to the ecological service value in 2000 was farmland, but in 2010 and 2020, it was the forest ecosystem. The ecological service value of grassland and wetland was relatively small, while the ratio of the wetland ecological service value displayed a decreasing trend. In the future, it is necessary to establish a strict pretrial system for land use, so as to effectively protect the natural and semi-natural ecosystems and fulfill the growing ecological demands of residents.

Cycle stability of lithium/garnet/lithium cells with different intermediate layers

The garnet-type electrolytes such as Ta-doped Li_7La_3Zr_2O_(12)(LLZTO) have been viewed as the promising electrolytes for solid-state lithium batteries, but it exhibits problem of high interfacial resistance(1960 Ω·cm^2) and short circuit when being cycled in Li/LLZTO/Li cells at the current density above 0.5 mA·cm^(-2). Introduction of intermediate layers in between lithium and LLZTO is helpful for decreasing the interfacial resistance and suppressing the growth of lithium dendrites. In this work, three kinds of intermediate layers of Au, Nb and Si with the thickness of 100 nm were prepared. Although the interfacial resistance with the Au layer decreases from 1960 to 32 Ω·cm^2, the cells can only cycle for 0.67 h at 0.5 mA·cm^(-2), related to the Au peeled off from the LLZTO. The Nb layers lead to the initial interfacial resistance of 14 Ω·cm^2, while showing extension of cycle time to 50 h with the increase in interfacial resistance due to the formation of the resistive Li–Nb–O phase. The Si layers induce the interfacial resistance as low as 5 Ω·cm^2 and the cycles as long as 120 h, which is attributed to the improvement in electrical contact between Li and electrolyte as well as the maintenance of conductive interface during cycles.

INFLUENCE OF CaF_(2)-4LiF ADDITIVE ON SINTERING AND ENERGY STORAGE PERFORMANCE OF SrTiO_(3)CERAMICS

The CaF_(2)-4LiF additive was added into SrTiO_(3)ceramics in order to decrease the sintering temperature for compact pulse power application.The crystalline structure,microstructure and energy storage performance of sintered ceramics were studied.Incorporating CaF_(2)-4LiF additive to SrTiO_(3)ceramics contributes to a notably enhancement of the energy storage density.The great enhancement in energy storage density occurred due to the notable increase in breakdown strength and the refinement of microstructure.With 2 at%additive,the samples exhibited an average breakdown strength of 31.8kV/mm,and an energy storage density of 1.212 J/cm^(3)which is about 1.4 times higher than pure SrTiO_(3).