The immunomodulating effects of F12 on mouse peritoneal macrophages was intended to be studied with different doses of 20, 40, 80 and 120mg/Kg. F12 increased peroxidase activity in dexc dependent mammer from 0.02±...The immunomodulating effects of F12 on mouse peritoneal macrophages was intended to be studied with different doses of 20, 40, 80 and 120mg/Kg. F12 increased peroxidase activity in dexc dependent mammer from 0.02±0.001 to 0.175±0.038, 0.211±0.041, 0.137±0.045 and 0.078±0.036, respectively, increased cytotoxicity from 127.33±22.96 to 162.74±19.53, 237.30±25.15 , 178.62±36.22 and 158.66±42.75dpm, respectively, promoted phagocytic activity from 0.03±0.01 to0.21±0.016, 0.43±0.041, 0.40±0.032 and 0.30±0.160b. Furthermore, F12 in a concentration of 15, 30,60,120μg/ml enhanced IL-1 production from 0.15±0.02 to 0.20±0.005b 0.21±0.02,0.22±0.005,0.24±0.002 and 0.22±0.02,respectively. Thus F12 can be considered as an effective stimulator of macrophages.展开更多
基金The National 95 Key-Attacking Studies (96-C01-05-02)
文摘The immunomodulating effects of F12 on mouse peritoneal macrophages was intended to be studied with different doses of 20, 40, 80 and 120mg/Kg. F12 increased peroxidase activity in dexc dependent mammer from 0.02±0.001 to 0.175±0.038, 0.211±0.041, 0.137±0.045 and 0.078±0.036, respectively, increased cytotoxicity from 127.33±22.96 to 162.74±19.53, 237.30±25.15 , 178.62±36.22 and 158.66±42.75dpm, respectively, promoted phagocytic activity from 0.03±0.01 to0.21±0.016, 0.43±0.041, 0.40±0.032 and 0.30±0.160b. Furthermore, F12 in a concentration of 15, 30,60,120μg/ml enhanced IL-1 production from 0.15±0.02 to 0.20±0.005b 0.21±0.02,0.22±0.005,0.24±0.002 and 0.22±0.02,respectively. Thus F12 can be considered as an effective stimulator of macrophages.