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Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL-null mice
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作者 S-ELAMHAMEDI-CHERRADI SHIJUNZHENG +2 位作者 KIMBERLYAMAGUSCHAK JACQUESPESCHON youhaichen 《Cell Research》 SCIE CAS CSCD 2002年第3期281-281,共1页
Immunological tolerance to self is essential for maintaining the integrity of the organ systems, and its breakdown may lead to the development of autoimmune diseases. Tolerance to self is maintained through several me... Immunological tolerance to self is essential for maintaining the integrity of the organ systems, and its breakdown may lead to the development of autoimmune diseases. Tolerance to self is maintained through several mechanisms, which include negative selection, functional inactivation (anergy) and suppression of autoreactive lymphocytes. However, only negative selection permanently removes autoreactive cells through apoptosis. While it has long been known that negative selection requires a T cell receptor (TCR) signal, it is unclear whether a death ligand signal is also involved. TRAIL, the tumor necrosis factor (TNF)-related apoptosis-inducing ligand, is a newly described member of the TNF family. Unlike other death ligands 展开更多
关键词 自身免疫性疾病 TNF TRAIL缺乏小鼠 缺陷型淋巴细胞凋亡
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Peripheral clonal deletion of MBP-specific T cells by intravenous au-toantigen: rapid reversal of ongoing, progressive experimental autoimmune encephalomyelitis
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作者 GUANGXIANZHANG DIVINACALIDA +3 位作者 THOMASTLIU ELVIASVENTURA youhaichen AMROSTAMI 《Cell Research》 SCIE CAS CSCD 2002年第3期284-284,共1页
Experimental autoimmune encephalomyelitis can be initiated spontaneously and developed progressively in TCR transgenic mice specific for myelin basic protein when exposed to non-sterile environment, thus more closely ... Experimental autoimmune encephalomyelitis can be initiated spontaneously and developed progressively in TCR transgenic mice specific for myelin basic protein when exposed to non-sterile environment, thus more closely mimicking human multiple sclerosis. By intravenous administration of myelin basic protein, we succeeded in rapidly reversing the clinical and pathological signs of progressive spontaneous disease in these mice. The majority of transgenic T cells of MBP-injected mice was deleted, with dramatically increased numbers of apoptotic cells, in lymph nodes and spleen, but not in thymus. Proliferative responses of 展开更多
关键词 实验性自身免疫性脑脊髓炎 快速逆转 自身抗原静注 MBP特异性T细胞缺失
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