1 INTRODUCTION Wood-rotting fungi have been intensively studied in China (Dai & Niemel? 2002; Dai et al. 2003, 2004a, 2004b; Dai & Penttil? 2006), and some new species and new records were found
目的:观察活性维生素D_(3)对老年肌少症合并糖尿病患者的干预效果。方法:收集2020年1—6月在我院收治的120例65~85岁的老年肌少症合并糖尿病的患者为研究对象。按照随机数字表随机分为观察组和对照组各60例,2组患者间性别、年龄、身高...目的:观察活性维生素D_(3)对老年肌少症合并糖尿病患者的干预效果。方法:收集2020年1—6月在我院收治的120例65~85岁的老年肌少症合并糖尿病的患者为研究对象。按照随机数字表随机分为观察组和对照组各60例,2组患者间性别、年龄、身高、体重、BMI无差异,具有可比性。两组患者均采用药物控制血糖,进行营养干预改善肌少症症状,观察组患者在此基础上给予口服骨化三醇,每次0.25μg,每天2次,连续服用48 w。于治疗前和治疗48 w后,收集患者清晨空腹静脉血,测定血清25(OH)D_(3)水平、空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、糖化血红蛋白(HbA1c)、空腹胰岛素水平(FINS),计算胰岛素抵抗指数(HOMA-IR);于干预前后测量骨骼肌肌量(ASM、ASM/H^(2))、优势手握力(HGS)及骨骼肌活动能力(SPPB),比较干预前后骨骼肌肌量、肌肉力量、骨骼肌活动能力、血糖变化及胰岛素抵抗状况。结果:2组患者治疗前,血清25(OH)D_(3)水平无差异[(13.85±2.51)vs(14.30±2.35)]mmol/L;治疗后,观察组患者血清25(OH)D_(3)水平显著增高,且高于对照组患者[(23.92±2.23)vs(14.73±2.12)]mmol/L(P<0.05);治疗前,2组患者ASM、ASM/H^(2)、HGS、SPPB均无差异;治疗后,观察组患者HGS和SPPB显著改善,均高于对照组指标(P<0.05)。治疗前,2组患者FBG、2 h PBG、HbA1c、HOMA-IR均无差异(P>0.05);治疗后,2组患者FBG、2 h PBG、HbA1c、HOMA-IR指标均显著下降,且观察组下降水平显著高于对照组患者(P<0.05)。结论:活性维生素D_(3)干预老年肌少症合并糖尿病患者48 w,能够显著提高血清维生素D水平,改善肌肉力量和骨骼肌活动能力,降低血糖水平,减轻胰岛素抵抗。展开更多
For any given positive integer m, let X_i, 1 ≤ i ≤ m be m independent random variables with distributions F_i, 1 ≤ i ≤ m. When all the summands are nonnegative and at least one of them is heavy-tailed, we prove th...For any given positive integer m, let X_i, 1 ≤ i ≤ m be m independent random variables with distributions F_i, 1 ≤ i ≤ m. When all the summands are nonnegative and at least one of them is heavy-tailed, we prove that the lower limit of the ratio ■equals 1 as x →∞. When the summands are real-valued, we also obtain some asymptotic results for the tail probability of the sums. Besides, a local version as well as a density version of the above results is also presented.展开更多
基金Supported by National Nature Science Foundation of China （No. 30670009）We thank Drs. YUAN Hai-Sheng and WANG Han-Chen （Shenyang, China） for companion in the field trip.
文摘1 INTRODUCTION Wood-rotting fungi have been intensively studied in China (Dai & Niemel? 2002; Dai et al. 2003, 2004a, 2004b; Dai & Penttil? 2006), and some new species and new records were found
文摘目的:观察活性维生素D_(3)对老年肌少症合并糖尿病患者的干预效果。方法:收集2020年1—6月在我院收治的120例65~85岁的老年肌少症合并糖尿病的患者为研究对象。按照随机数字表随机分为观察组和对照组各60例,2组患者间性别、年龄、身高、体重、BMI无差异,具有可比性。两组患者均采用药物控制血糖,进行营养干预改善肌少症症状,观察组患者在此基础上给予口服骨化三醇,每次0.25μg,每天2次,连续服用48 w。于治疗前和治疗48 w后,收集患者清晨空腹静脉血,测定血清25(OH)D_(3)水平、空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、糖化血红蛋白(HbA1c)、空腹胰岛素水平(FINS),计算胰岛素抵抗指数(HOMA-IR);于干预前后测量骨骼肌肌量(ASM、ASM/H^(2))、优势手握力(HGS)及骨骼肌活动能力(SPPB),比较干预前后骨骼肌肌量、肌肉力量、骨骼肌活动能力、血糖变化及胰岛素抵抗状况。结果:2组患者治疗前,血清25(OH)D_(3)水平无差异[(13.85±2.51)vs(14.30±2.35)]mmol/L;治疗后,观察组患者血清25(OH)D_(3)水平显著增高,且高于对照组患者[(23.92±2.23)vs(14.73±2.12)]mmol/L(P<0.05);治疗前,2组患者ASM、ASM/H^(2)、HGS、SPPB均无差异;治疗后,观察组患者HGS和SPPB显著改善,均高于对照组指标(P<0.05)。治疗前,2组患者FBG、2 h PBG、HbA1c、HOMA-IR均无差异(P>0.05);治疗后,2组患者FBG、2 h PBG、HbA1c、HOMA-IR指标均显著下降,且观察组下降水平显著高于对照组患者(P<0.05)。结论:活性维生素D_(3)干预老年肌少症合并糖尿病患者48 w,能够显著提高血清维生素D水平,改善肌肉力量和骨骼肌活动能力,降低血糖水平,减轻胰岛素抵抗。
基金Supported by the National Natural Science Foundation of China(no.11401415)Tian Yuan Foundation(nos.11226208 and 11426139)+2 种基金Natural Science Foundation of the Jiangsu Higher Education Institutions of China(no.13KJB110025)Postdoctoral Research Program of Jiangsu Province of China(no.1402111C)Jiangsu Overseas Research and Training Program for Prominent University Young and Middle-aged Teachers and Presidents
文摘For any given positive integer m, let X_i, 1 ≤ i ≤ m be m independent random variables with distributions F_i, 1 ≤ i ≤ m. When all the summands are nonnegative and at least one of them is heavy-tailed, we prove that the lower limit of the ratio ■equals 1 as x →∞. When the summands are real-valued, we also obtain some asymptotic results for the tail probability of the sums. Besides, a local version as well as a density version of the above results is also presented.
