Seven new isoquinoline alkaloids,9-(2’-formyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy dehydroaporphine(1),9-(2’-formyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy oxoaporphine(2),3-methoxy-2’-formyl oxo...Seven new isoquinoline alkaloids,9-(2’-formyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy dehydroaporphine(1),9-(2’-formyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy oxoaporphine(2),3-methoxy-2’-formyl oxohernandalin(3),(–)-9-(2’-methoxycarbonyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy aporphine(4),(–)-2’-methoxycarbonyl thaliadin(5),(–)-9-(2’-methoxyethyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy aporphine(6),(–)-3-methoxy hydroxyhernandalinol(7),together with six known isoquinoline alkaloids(8–13)were isolated from the roots of Thalictrum foetidum.Their structures were elucidated by extensive spectroscopic measurements.Compounds 1 and 2 showed significant selective cytotoxicity against glioma stem cells(GSC-3#and GSC-18#)with IC50 values ranging from 2.36 to 5.37μg·mL^–1.展开更多
基金supported by the Natural Science Foundation of China(U1802281,31770388)
文摘Seven new isoquinoline alkaloids,9-(2’-formyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy dehydroaporphine(1),9-(2’-formyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy oxoaporphine(2),3-methoxy-2’-formyl oxohernandalin(3),(–)-9-(2’-methoxycarbonyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy aporphine(4),(–)-2’-methoxycarbonyl thaliadin(5),(–)-9-(2’-methoxyethyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy aporphine(6),(–)-3-methoxy hydroxyhernandalinol(7),together with six known isoquinoline alkaloids(8–13)were isolated from the roots of Thalictrum foetidum.Their structures were elucidated by extensive spectroscopic measurements.Compounds 1 and 2 showed significant selective cytotoxicity against glioma stem cells(GSC-3#and GSC-18#)with IC50 values ranging from 2.36 to 5.37μg·mL^–1.
