Dengue fever is caused by the dengue virus and transmitted by Aedes mosquitoes.A promising avenue for eradicating the disease is to infect the wild aedes population with the bacterium Wolbachia driven by cytoplasmic i...Dengue fever is caused by the dengue virus and transmitted by Aedes mosquitoes.A promising avenue for eradicating the disease is to infect the wild aedes population with the bacterium Wolbachia driven by cytoplasmic incompatibility(CI).When releasing Wolbachia infected mosquitoes for population replacement,it is essential to not ignore the spatial inhomogeneity of wild mosquito distribution.In this paper,we develop a model of reaction-diffusion system to investigate the infection dynamics in natural areas,under the assumptions supported by recent experiments such as perfect maternal transmission and complete CI.We prove non-existence of inhomogeneous steady-states when one of the diffusion coefficients is sufficiently large,and classify local stability for constant steady states.It is seen that diffusion does not change the criteria for the local stabilities.Our major concern is to determine the minimum infection frequency above which Wolbachia can spread into the whole population of mosquitoes.We find that diffusion drives the minimum frequency slightly higher in general.However,the minimum remains zero when Wolbachia infection brings overwhelming fitness benefit.In the special case when the infection does not alter the longevity of mosquitoes but reduces the birth rate by half,diffusion has no impact on the minimum frequency.展开更多
We consider a reaction-diffusion model which describes the spatial Wolbachia spread dynamics for a mixed population of infected and uninfected mosquitoes. By using linearization method, comparison principle and Leray-...We consider a reaction-diffusion model which describes the spatial Wolbachia spread dynamics for a mixed population of infected and uninfected mosquitoes. By using linearization method, comparison principle and Leray-Schauder degree theory, we investigate the influence of diffusion on the Wolbachia infection dynamics.After identifying the system parameter regions in which diffusion alters the local stability of constant steadystates, we find sufficient conditions under which the system possesses inhomogeneous steady-states. Surprisingly,our mathematical analysis, with the help of numerical simulations, indicates that diffusion is able to lower the threshold value of the infection frequency over which Wolbachia can invade the whole population.展开更多
基金supported by National Natural Science Foundation of China(GrantNos.11471085 and 91230104)Program for Changjiang Scholars and Innovative Research Team in University(Grant No.IRT1226)+1 种基金Program for Yangcheng Scholars in Guangzhou(Grant No.12A003S)Natural Science Foundation of USA(Grant No.0531898)
文摘Dengue fever is caused by the dengue virus and transmitted by Aedes mosquitoes.A promising avenue for eradicating the disease is to infect the wild aedes population with the bacterium Wolbachia driven by cytoplasmic incompatibility(CI).When releasing Wolbachia infected mosquitoes for population replacement,it is essential to not ignore the spatial inhomogeneity of wild mosquito distribution.In this paper,we develop a model of reaction-diffusion system to investigate the infection dynamics in natural areas,under the assumptions supported by recent experiments such as perfect maternal transmission and complete CI.We prove non-existence of inhomogeneous steady-states when one of the diffusion coefficients is sufficiently large,and classify local stability for constant steady states.It is seen that diffusion does not change the criteria for the local stabilities.Our major concern is to determine the minimum infection frequency above which Wolbachia can spread into the whole population of mosquitoes.We find that diffusion drives the minimum frequency slightly higher in general.However,the minimum remains zero when Wolbachia infection brings overwhelming fitness benefit.In the special case when the infection does not alter the longevity of mosquitoes but reduces the birth rate by half,diffusion has no impact on the minimum frequency.
基金supported by National Natural Science Foundation of China (Grant Nos. 11471085, 91230104 and 11301103)Program for Changjiang Scholars and Innovative Research Team in University (Grant No. IRT1226)+1 种基金Program for Yangcheng Scholars in Guangzhou (Grant No. 12A003S)Guangdong Innovative Research Team Program (Grant No. 2011S009)
文摘We consider a reaction-diffusion model which describes the spatial Wolbachia spread dynamics for a mixed population of infected and uninfected mosquitoes. By using linearization method, comparison principle and Leray-Schauder degree theory, we investigate the influence of diffusion on the Wolbachia infection dynamics.After identifying the system parameter regions in which diffusion alters the local stability of constant steadystates, we find sufficient conditions under which the system possesses inhomogeneous steady-states. Surprisingly,our mathematical analysis, with the help of numerical simulations, indicates that diffusion is able to lower the threshold value of the infection frequency over which Wolbachia can invade the whole population.
