目的研究临床特征及实验室指标联合预测急性ST段抬高型心肌梗死(acute ST-segment elevation myocardial infarction,STEMI)患者梗死相关动脉(infarction related artery,IRA)自发再通风险的价值。方法选择本院收治的375例急性STEMI患...目的研究临床特征及实验室指标联合预测急性ST段抬高型心肌梗死(acute ST-segment elevation myocardial infarction,STEMI)患者梗死相关动脉(infarction related artery,IRA)自发再通风险的价值。方法选择本院收治的375例急性STEMI患者作为研究对象,患者入院后行急诊冠状动脉造影,将IRA血流心肌梗死溶栓试验(thrombolysis in myocardial infarction,TIMI)2~3级患者纳入自发再通组(114例),将IRA血流TIMI 0~1级患者纳入非自发再通组(261例)。收集患者临床资料,包括性别、年龄、体重指数(body mass index,BMI)、是否吸烟、有无高血压或糖尿病、有无梗死前心绞痛等,记录患者心率、病变支数和梗死部位,检测血清空腹血糖、纤维蛋白原(fibrinogen,FIB)、白蛋白(albumin,Alb)、肌酸激酶同工酶(creatine kinase isoenzyme,CK-MB)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、脂蛋白α[Lipoprotein alpha,Lp(α)]水平,计算FIB/Alb比值(fibrinogen to albumin ratio,FAR)值;以ROC曲线分析FIB、CK-MB、FAR、Lp(α)预测急性STEMI患者IRA自发再通风险的价值;采取非条件Logistic逐步回归分析急性STEMI患者IRA自发再通的影响因素;以一致性分析多项预测因素联合预测急性STEMI患者IRA自发再通风险的价值。结果经单因素分析,与非自发再通组相比,自发再通组吸烟患者比例较低、梗死前心绞痛患者比例较高,并且自发再通组患者FIB、CK-MB、FAR、Lp(α)水平较低(P<0.05);经ROC分析证实,FIB≤359.440 mg/L、CK-MB≤73.460 U/L、FAR值≤9.585、Lp(α)≤150.947 nmol/L是急性STEMI患者IRA自发再通的最佳截断值,且均有P<0.05;多因素Logistic回归性分析显示,吸烟、梗死前心绞痛、FIB水平≤359.440 mg/L、CK-MB水平≤73.460 U/L、FAR值≤9.585、Lp(α)≤150.947 nmol/L是急性STEMI患者IRA自发再通的影响因素(P<0.05);经一致性分析,多项预测因素联合预测急性STEMI患者IRA自发再通的敏感度为0.930、特异度为0.931、准确率为0.931、Kappa值=0.840。结论FIB水平≤359.440 mg/L、CK-MB水平≤73.460 U/L、FAR值≤9.585、Lp(α)≤150.947 nmol/L是急性STEMI患者IRA自发再通的最佳截断值,吸烟和梗死前心绞痛可能是自发再通的影响因素,多项因素联合预测急性STEMI患者IRA自发再通风险具有较高的准确率。展开更多
目的研究5-羟色胺受体基因启动子区(5-HTTLPR)多态性与功能性消化不良(FD)发病之间的关系,为疾病提供临床治疗信息。方法计算机检索PubMed、EMbase、Web of Science、中国生物医学文献数据库、CNKI、万方等数据库,检索截止时间至2018年5...目的研究5-羟色胺受体基因启动子区(5-HTTLPR)多态性与功能性消化不良(FD)发病之间的关系,为疾病提供临床治疗信息。方法计算机检索PubMed、EMbase、Web of Science、中国生物医学文献数据库、CNKI、万方等数据库,检索截止时间至2018年5月18日,筛选5-HTTLPR基因多态性与FD发病相关研究,运用Stata 12.0软件进行Meta分析。结果共纳入6篇研究,S(短)及L(长)等位基因组成5种遗传模型。SS+LS vs LL模型与FD发病风险相关(OR=0.50,95%CI:0.25～0.98),其余遗传模型与FD发病无关(SS vs LL+LS:OR=1.02,95%CI:0.70～1.50;SS vs LL:OR=1.01,95%CI:0.68～1.50;SS vs LS:OR=1.08,95%CI:0.70～1.68;S vs L:OR=0.96,95%CI:0.81～1.14),亚洲人群SS+LS vs LL模型与FD发病风险相关(OR=0.53,95%CI:0.29～0.97),其余模型未见明显相关,高加索人群各遗传模型与FD发病风险无关。剔除一篇文章后,无论汇总结果还是亚组分析均提示各遗传模型与FD发病风险无明显相关。结论无论在亚洲还是高加索人群中,5-HTTLPR基因多态性与FD发病风险无明显相关。展开更多
The self-assembly of clusters in inorganic systems is an interesting subject. The self-assembly of big molecules has been well established in biological systems. In addition, the coordination chemistry of metal-sulfur...The self-assembly of clusters in inorganic systems is an interesting subject. The self-assembly of big molecules has been well established in biological systems. In addition, the coordination chemistry of metal-sulfur-nitrogen cluster complexes has been a very active and attracting field for many years as a result of the novelty and versatility of the crystal structures and reactivities of such clusters, as well as their potential applications as the models for the active sites in non-heme proteins. At the same time, there is currently considerable interest in the formation of metal complexes with heterocyclic ligands because of the diverse characteristics of ligands and their consequential wide range of applications.展开更多
文摘目的研究临床特征及实验室指标联合预测急性ST段抬高型心肌梗死(acute ST-segment elevation myocardial infarction,STEMI)患者梗死相关动脉(infarction related artery,IRA)自发再通风险的价值。方法选择本院收治的375例急性STEMI患者作为研究对象,患者入院后行急诊冠状动脉造影,将IRA血流心肌梗死溶栓试验(thrombolysis in myocardial infarction,TIMI)2~3级患者纳入自发再通组(114例),将IRA血流TIMI 0~1级患者纳入非自发再通组(261例)。收集患者临床资料,包括性别、年龄、体重指数(body mass index,BMI)、是否吸烟、有无高血压或糖尿病、有无梗死前心绞痛等,记录患者心率、病变支数和梗死部位,检测血清空腹血糖、纤维蛋白原(fibrinogen,FIB)、白蛋白(albumin,Alb)、肌酸激酶同工酶(creatine kinase isoenzyme,CK-MB)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、脂蛋白α[Lipoprotein alpha,Lp(α)]水平,计算FIB/Alb比值(fibrinogen to albumin ratio,FAR)值;以ROC曲线分析FIB、CK-MB、FAR、Lp(α)预测急性STEMI患者IRA自发再通风险的价值;采取非条件Logistic逐步回归分析急性STEMI患者IRA自发再通的影响因素;以一致性分析多项预测因素联合预测急性STEMI患者IRA自发再通风险的价值。结果经单因素分析,与非自发再通组相比,自发再通组吸烟患者比例较低、梗死前心绞痛患者比例较高,并且自发再通组患者FIB、CK-MB、FAR、Lp(α)水平较低(P<0.05);经ROC分析证实,FIB≤359.440 mg/L、CK-MB≤73.460 U/L、FAR值≤9.585、Lp(α)≤150.947 nmol/L是急性STEMI患者IRA自发再通的最佳截断值,且均有P<0.05;多因素Logistic回归性分析显示,吸烟、梗死前心绞痛、FIB水平≤359.440 mg/L、CK-MB水平≤73.460 U/L、FAR值≤9.585、Lp(α)≤150.947 nmol/L是急性STEMI患者IRA自发再通的影响因素(P<0.05);经一致性分析,多项预测因素联合预测急性STEMI患者IRA自发再通的敏感度为0.930、特异度为0.931、准确率为0.931、Kappa值=0.840。结论FIB水平≤359.440 mg/L、CK-MB水平≤73.460 U/L、FAR值≤9.585、Lp(α)≤150.947 nmol/L是急性STEMI患者IRA自发再通的最佳截断值,吸烟和梗死前心绞痛可能是自发再通的影响因素,多项因素联合预测急性STEMI患者IRA自发再通风险具有较高的准确率。
文摘目的研究5-羟色胺受体基因启动子区(5-HTTLPR)多态性与功能性消化不良(FD)发病之间的关系,为疾病提供临床治疗信息。方法计算机检索PubMed、EMbase、Web of Science、中国生物医学文献数据库、CNKI、万方等数据库,检索截止时间至2018年5月18日,筛选5-HTTLPR基因多态性与FD发病相关研究,运用Stata 12.0软件进行Meta分析。结果共纳入6篇研究,S(短)及L(长)等位基因组成5种遗传模型。SS+LS vs LL模型与FD发病风险相关(OR=0.50,95%CI:0.25～0.98),其余遗传模型与FD发病无关(SS vs LL+LS:OR=1.02,95%CI:0.70～1.50;SS vs LL:OR=1.01,95%CI:0.68～1.50;SS vs LS:OR=1.08,95%CI:0.70～1.68;S vs L:OR=0.96,95%CI:0.81～1.14),亚洲人群SS+LS vs LL模型与FD发病风险相关(OR=0.53,95%CI:0.29～0.97),其余模型未见明显相关,高加索人群各遗传模型与FD发病风险无关。剔除一篇文章后,无论汇总结果还是亚组分析均提示各遗传模型与FD发病风险无明显相关。结论无论在亚洲还是高加索人群中,5-HTTLPR基因多态性与FD发病风险无明显相关。
基金Supported by the National Natural Science Foundation of China(Nos. 20476011 and 20371007).
文摘The self-assembly of clusters in inorganic systems is an interesting subject. The self-assembly of big molecules has been well established in biological systems. In addition, the coordination chemistry of metal-sulfur-nitrogen cluster complexes has been a very active and attracting field for many years as a result of the novelty and versatility of the crystal structures and reactivities of such clusters, as well as their potential applications as the models for the active sites in non-heme proteins. At the same time, there is currently considerable interest in the formation of metal complexes with heterocyclic ligands because of the diverse characteristics of ligands and their consequential wide range of applications.
