Chronic non-communicable diseases （NCDs） is a sick- state in the complex system of human body. Healthsystems engineering approach can be used to recover health state by many different ways of system adjustments, inc...Chronic non-communicable diseases （NCDs） is a sick- state in the complex system of human body. Healthsystems engineering approach can be used to recover health state by many different ways of system adjustments, including physical exercises, nutrition and psychological intervention, and drug therapies. To evaluate and assess the effects of these adjustments, many parameters of the system states have to be monitored （such as molecular high- throughput technologies, physiological, image, etc.）, and estimated at the different levels （such as molecular, cellular, tissue, organ, and system levels） and on the different dimensions （such as metabolic, immune, neural, etc.） for human system. Huge data have been produced during the whole process, and health systems engineering approach will model health and sick state in the human system by detecting and analyzing these multi-dimension and multi- level big-data in order to find personal suitable adjustment method.展开更多
In previous research, time-delay （△t） was a more important parameter than the reflection coefficient in the individual transfer function of central aortic pressure reconstruction. The At can be obtained by electroc...In previous research, time-delay （△t） was a more important parameter than the reflection coefficient in the individual transfer function of central aortic pressure reconstruction. The At can be obtained by electrocardiography （ECG） or phonocardiography （PCG）. Because the pre-ejection period remains an uncertain factor, the present study used ECG and PCG to define the delay time and analyzed the accuracy of the reconstruction results. The △tpre is the actual delay time derived from the aorta to the carotid pressure wave, △tpco is the time delay between the aortic valve component of the second heart sound and the dicrotic incisura of the carotid pressure wave, and AtEcc represents the delay from the interval of the ECG R-peak to the foot of the carotid pressure wave. Compared with the measured aortic pressure, the reconstruction result obtained by △t=△tpcslightly differed from the best result estimated by △t=△tpre. However, the differences between the result obtained by △t=△tEco and the best result were significant in terms of the diastolic blood pressure, and pulse pressure, and especially in terms of the augmentation index and root-mean-square-error. Thus, the At should be determined by PCG for central aortic pressure reconstruction in practice.展开更多
文摘Chronic non-communicable diseases （NCDs） is a sick- state in the complex system of human body. Healthsystems engineering approach can be used to recover health state by many different ways of system adjustments, including physical exercises, nutrition and psychological intervention, and drug therapies. To evaluate and assess the effects of these adjustments, many parameters of the system states have to be monitored （such as molecular high- throughput technologies, physiological, image, etc.）, and estimated at the different levels （such as molecular, cellular, tissue, organ, and system levels） and on the different dimensions （such as metabolic, immune, neural, etc.） for human system. Huge data have been produced during the whole process, and health systems engineering approach will model health and sick state in the human system by detecting and analyzing these multi-dimension and multi- level big-data in order to find personal suitable adjustment method.
基金supported by the National Natural Science Foundation of China(81271737)
文摘In previous research, time-delay （△t） was a more important parameter than the reflection coefficient in the individual transfer function of central aortic pressure reconstruction. The At can be obtained by electrocardiography （ECG） or phonocardiography （PCG）. Because the pre-ejection period remains an uncertain factor, the present study used ECG and PCG to define the delay time and analyzed the accuracy of the reconstruction results. The △tpre is the actual delay time derived from the aorta to the carotid pressure wave, △tpco is the time delay between the aortic valve component of the second heart sound and the dicrotic incisura of the carotid pressure wave, and AtEcc represents the delay from the interval of the ECG R-peak to the foot of the carotid pressure wave. Compared with the measured aortic pressure, the reconstruction result obtained by △t=△tpcslightly differed from the best result estimated by △t=△tpre. However, the differences between the result obtained by △t=△tEco and the best result were significant in terms of the diastolic blood pressure, and pulse pressure, and especially in terms of the augmentation index and root-mean-square-error. Thus, the At should be determined by PCG for central aortic pressure reconstruction in practice.
