目的系统评价新型口服抗凝药(NOACs)用于非瓣膜性房颤患者左心耳封堵(LAAO)术后抗栓的有效性和安全性。方法计算机检索PubMed、Embase、Web of Science、Cochrane图书馆、中国知网、万方数据,收集NOACs(试验组)对比华法林或双联抗血小板...目的系统评价新型口服抗凝药(NOACs)用于非瓣膜性房颤患者左心耳封堵(LAAO)术后抗栓的有效性和安全性。方法计算机检索PubMed、Embase、Web of Science、Cochrane图书馆、中国知网、万方数据,收集NOACs(试验组)对比华法林或双联抗血小板药(对照组)的随机对照试验(RCT)和队列研究,检索时限为建库至2022年11月。筛选文献、提取数据、评价质量后,采用RevMan 5.4软件进行Meta分析。结果纳入10项研究,包括2项RCT、8项队列研究,共计2653例患者。RCT结果显示,两组患者的器械相关性血栓(DRT)发生率、卒中/全身性栓塞(SSE)发生率、大出血事件发生率、总出血事件发生率、全因死亡率比较,差异均无统计学意义(P>0.05)。队列研究结果显示,与双联抗血小板药比较,试验组患者的DRT发生率、卒中/SSE发生率、大出血事件发生率、全因死亡率差异均无统计学意义(P>0.05);与华法林比较,试验组患者的DRT发生率[RR=0.40,95%CI(0.19,0.82),P=0.01]、总出血事件发生率[RR=0.28,95%CI(0.18,0.44),P<0.00001]均显著降低,而卒中/SSE发生率、大出血事件发生率、全因死亡率差异均无统计学意义(P>0.05)。结论NOACs用于非瓣膜性房颤患者LAAO术后的疗效和安全性与双联抗血小板药相当,DRT发生率和总出血事件发生率低于华法林。展开更多
Co-primary spectrum sharing for multiple operators has been utilized to fully explore the spectrum resources and thus improve the spectrum efficiency. The inter-operator interference(IOI) problem should be seriously c...Co-primary spectrum sharing for multiple operators has been utilized to fully explore the spectrum resources and thus improve the spectrum efficiency. The inter-operator interference(IOI) problem should be seriously considered in order to achieve the mentioned target, especially under the scenario of the ultradense network(UDN) in the fifth generation(5G) wireless systems. To solve this problem, we propose an asymmetrical power levels based soft IOI coordination mechanism. The shared spectrum pool is consisted of three separated parts, where each part can be dynamically adjusted according to the minimal spectrum demand from each operator. Furthermore, different power masks are configured to different parts for each operator. The simulation results show that the proposed mechanism can improve the network spectrum efficiency significantly.展开更多
文摘目的系统评价新型口服抗凝药(NOACs)用于非瓣膜性房颤患者左心耳封堵(LAAO)术后抗栓的有效性和安全性。方法计算机检索PubMed、Embase、Web of Science、Cochrane图书馆、中国知网、万方数据,收集NOACs(试验组)对比华法林或双联抗血小板药(对照组)的随机对照试验(RCT)和队列研究,检索时限为建库至2022年11月。筛选文献、提取数据、评价质量后,采用RevMan 5.4软件进行Meta分析。结果纳入10项研究,包括2项RCT、8项队列研究,共计2653例患者。RCT结果显示,两组患者的器械相关性血栓(DRT)发生率、卒中/全身性栓塞(SSE)发生率、大出血事件发生率、总出血事件发生率、全因死亡率比较,差异均无统计学意义(P>0.05)。队列研究结果显示,与双联抗血小板药比较,试验组患者的DRT发生率、卒中/SSE发生率、大出血事件发生率、全因死亡率差异均无统计学意义(P>0.05);与华法林比较,试验组患者的DRT发生率[RR=0.40,95%CI(0.19,0.82),P=0.01]、总出血事件发生率[RR=0.28,95%CI(0.18,0.44),P<0.00001]均显著降低,而卒中/SSE发生率、大出血事件发生率、全因死亡率差异均无统计学意义(P>0.05)。结论NOACs用于非瓣膜性房颤患者LAAO术后的疗效和安全性与双联抗血小板药相当,DRT发生率和总出血事件发生率低于华法林。
基金supported by National High Technology Research and Development Program of China under Grants No.2014AA01A701major project of Ministry of Industry and Information Technology of China under Grant No.2015ZX03001032+1 种基金major project of Shanghai under Grant No.,14511101501National Natural Science Foundation of China under Grant No.61471347
文摘Co-primary spectrum sharing for multiple operators has been utilized to fully explore the spectrum resources and thus improve the spectrum efficiency. The inter-operator interference(IOI) problem should be seriously considered in order to achieve the mentioned target, especially under the scenario of the ultradense network(UDN) in the fifth generation(5G) wireless systems. To solve this problem, we propose an asymmetrical power levels based soft IOI coordination mechanism. The shared spectrum pool is consisted of three separated parts, where each part can be dynamically adjusted according to the minimal spectrum demand from each operator. Furthermore, different power masks are configured to different parts for each operator. The simulation results show that the proposed mechanism can improve the network spectrum efficiency significantly.
