目的探索多学科综合教学模式(multidisciplinary treatment,MDT)在颅内肿瘤加速康复外科(enhanced recovery after surgery,ERAS)临床教学中的应用效果。方法将华中科技大学同济医学院附属同济医院神经外科于2018年6月-2019年7月期间接...目的探索多学科综合教学模式(multidisciplinary treatment,MDT)在颅内肿瘤加速康复外科(enhanced recovery after surgery,ERAS)临床教学中的应用效果。方法将华中科技大学同济医学院附属同济医院神经外科于2018年6月-2019年7月期间接受住院医师规范化培训的70名人员随机分为两组,A组为MDT教学组,B组为传统教学组。培训期满时,对两组规范化培训人员进行出科考试,并发放满意度调查问卷,了解不同分组对教学成果的满意情况。结果出科成绩和满意度调查的结果显示,A组结果均高于B组,差异具有统计学意义(P <0.05)。结论在颅内肿瘤ERAS的住院医师规范化培训教学中,MDT模式能提高规范化培训人员的理论实践能力及其对教学效果的满意度。展开更多
Objective： To evaluate the effects of gemcitabine on the microvessel density （MVD） and apoptosis in radiotherapy of cervical cancer. Methods： Forty-seven patients with locally advanced cervical cancer （ⅡB, Ⅲ an...Objective： To evaluate the effects of gemcitabine on the microvessel density （MVD） and apoptosis in radiotherapy of cervical cancer. Methods： Forty-seven patients with locally advanced cervical cancer （ⅡB, Ⅲ and IVA stage） were divided into two groups randomly： group A, 22 cases receiving radiotherapy combined with gemcitabine; group B, 25 cases receiving radiotherapy only. Tissue specimens were obtained from cervical tumor of all patients before and 24 h after radiotherapy with 10 Gy. MVD and apoptosis was detected by immunohistochemical staining and TUNEL assay respectively. Results： MVD （median） in group A was significantly reduced as compared with group B （P=0.001）. A-LI （median） in group A was significantly increased as compared with group B （P=0.034）. T0.5 in group A was significantly shorter than that in group B （P=0.018）. The reduction of MVD in group A was negatively correlated with T0.5 （r=-0.628）. There was no significant difference in gastrointestinal and haematological adverse effects between group A and group B. Conclusion： Gemcitabine, a novel potential radiosensitizer, can decrease the neoangiogenesis, increase the apoptosis in the early stage of radiotherapy of cervical cancer.展开更多
文摘Objective： To evaluate the effects of gemcitabine on the microvessel density （MVD） and apoptosis in radiotherapy of cervical cancer. Methods： Forty-seven patients with locally advanced cervical cancer （ⅡB, Ⅲ and IVA stage） were divided into two groups randomly： group A, 22 cases receiving radiotherapy combined with gemcitabine; group B, 25 cases receiving radiotherapy only. Tissue specimens were obtained from cervical tumor of all patients before and 24 h after radiotherapy with 10 Gy. MVD and apoptosis was detected by immunohistochemical staining and TUNEL assay respectively. Results： MVD （median） in group A was significantly reduced as compared with group B （P=0.001）. A-LI （median） in group A was significantly increased as compared with group B （P=0.034）. T0.5 in group A was significantly shorter than that in group B （P=0.018）. The reduction of MVD in group A was negatively correlated with T0.5 （r=-0.628）. There was no significant difference in gastrointestinal and haematological adverse effects between group A and group B. Conclusion： Gemcitabine, a novel potential radiosensitizer, can decrease the neoangiogenesis, increase the apoptosis in the early stage of radiotherapy of cervical cancer.
