A dynamic genetic algorithms based on numeric encoding is proposed and its application in system identification is discussed. Simulation shows that the introduction of both numeric encoding and dynamic mutation can ef...A dynamic genetic algorithms based on numeric encoding is proposed and its application in system identification is discussed. Simulation shows that the introduction of both numeric encoding and dynamic mutation can effectively improve the accuracy and speed of searching for the optimum. It also show that the improved Genetic algorithm can identify time delay and parameters of the plant at the same time and converge to globle optimization.展开更多
A computer control system for drawing machine in horizontal continuous cast set was introduced.The operation features of the drawing machine were analyzed»the hardware configuration and principles of interface ci...A computer control system for drawing machine in horizontal continuous cast set was introduced.The operation features of the drawing machine were analyzed»the hardware configuration and principles of interface circuit for stroke measurements were given out.An effective method was provided,which made the process parameters progressively optimize under the software environment using friendly interface of person-and-computer communication.This method was also adaptable to optimize parameters of other production process which are hard to model.展开更多
The B-cell epitopes of virus are associated with the antiviral drug and the vaccine screening. As the nucleotide sequences of neuraminidase (NA) of stain GD-01-06 were sequenced, we predicted the α-helix and β-fold ...The B-cell epitopes of virus are associated with the antiviral drug and the vaccine screening. As the nucleotide sequences of neuraminidase (NA) of stain GD-01-06 were sequenced, we predicted the α-helix and β-fold structure and the indexes of the flexible regions of secondary structure of NA with methods of the Hydrophilicity plot by Kyte-Doolittle, the Surface probability plot by Emini and the Antigenic index by Jameson-Wolf, and then screened statistically the parameters to predict B-cell epitopes by the Hierarchical cluster and the Bivariate correlation and the quartiles with SPSS 13.0. The impact of variation of amino acids in NA on its epitopes was analyzed. The predictive results were evaluated by Wu’s Antigenic Index and SWISS-MODEL. We found that the most possible epitopes on NA were located within or nearby its N-terminal Nos. 120―137, 81―84, 408―415, 273―282, 429―432, 356―368, 46―55, 146―155, 341―350 and 198―209, which were the dominant regions of NA epitopes. Peptide 120―137 including the glycoprotein domain (NGT126―128) was first chosen as the B-cell epitopes on NA. NA in H5N1 strain isolated after 2003 lacked in No. 53 amino acid (I), resulting in an increase in the surface flexible region of NA in GD-01-06 and an enlargement to their epitope regions (VEP46―48→ VEPISNTNFL46―55). Conclusively, prediction of the B-cell epitopes on the NA based on multiple parameters is useful for researches on the molecular immunology and drug screening and immuno-prophylaxis. A deletion of No. 53 amino acid (I) in NA in strain GD-01-06 might increase its antigenicity.展开更多
文摘A dynamic genetic algorithms based on numeric encoding is proposed and its application in system identification is discussed. Simulation shows that the introduction of both numeric encoding and dynamic mutation can effectively improve the accuracy and speed of searching for the optimum. It also show that the improved Genetic algorithm can identify time delay and parameters of the plant at the same time and converge to globle optimization.
文摘A computer control system for drawing machine in horizontal continuous cast set was introduced.The operation features of the drawing machine were analyzed»the hardware configuration and principles of interface circuit for stroke measurements were given out.An effective method was provided,which made the process parameters progressively optimize under the software environment using friendly interface of person-and-computer communication.This method was also adaptable to optimize parameters of other production process which are hard to model.
基金the Scientific and Technological Project of Guangdong Province (Grant No. 2004A2090102).
文摘The B-cell epitopes of virus are associated with the antiviral drug and the vaccine screening. As the nucleotide sequences of neuraminidase (NA) of stain GD-01-06 were sequenced, we predicted the α-helix and β-fold structure and the indexes of the flexible regions of secondary structure of NA with methods of the Hydrophilicity plot by Kyte-Doolittle, the Surface probability plot by Emini and the Antigenic index by Jameson-Wolf, and then screened statistically the parameters to predict B-cell epitopes by the Hierarchical cluster and the Bivariate correlation and the quartiles with SPSS 13.0. The impact of variation of amino acids in NA on its epitopes was analyzed. The predictive results were evaluated by Wu’s Antigenic Index and SWISS-MODEL. We found that the most possible epitopes on NA were located within or nearby its N-terminal Nos. 120―137, 81―84, 408―415, 273―282, 429―432, 356―368, 46―55, 146―155, 341―350 and 198―209, which were the dominant regions of NA epitopes. Peptide 120―137 including the glycoprotein domain (NGT126―128) was first chosen as the B-cell epitopes on NA. NA in H5N1 strain isolated after 2003 lacked in No. 53 amino acid (I), resulting in an increase in the surface flexible region of NA in GD-01-06 and an enlargement to their epitope regions (VEP46―48→ VEPISNTNFL46―55). Conclusively, prediction of the B-cell epitopes on the NA based on multiple parameters is useful for researches on the molecular immunology and drug screening and immuno-prophylaxis. A deletion of No. 53 amino acid (I) in NA in strain GD-01-06 might increase its antigenicity.
