国际音乐感知与认知会议(International Conference on Music Perception and Cognition,简称ICMPC)始办于1989年,每两年一届,是目前音乐心理学领域最高规格的国际性学术会议。亚太地区音乐认知科学学会(The Asia-Pacific Society for t...国际音乐感知与认知会议(International Conference on Music Perception and Cognition,简称ICMPC)始办于1989年,每两年一届,是目前音乐心理学领域最高规格的国际性学术会议。亚太地区音乐认知科学学会(The Asia-Pacific Society for the Cognitive Sciences of Music,简称APSCOM)1会议每三年举办一次,致力于促进亚太地区音乐认知科学的研究活动及深化亚太地区研究人员之间的交流和友谊。展开更多
OBJECTIVE:To investigate the effects and mechanisms of the Jiawei Pentongling formula(加味盆痛灵方,JWPTL)in treating endometriosis-related pain using network pharmacology study and experimental validation.METHODS:Acti...OBJECTIVE:To investigate the effects and mechanisms of the Jiawei Pentongling formula(加味盆痛灵方,JWPTL)in treating endometriosis-related pain using network pharmacology study and experimental validation.METHODS:Active ingredients and relevant targets of JWPTL,as well as genes for endometriosis-related pain,were collected from public databases.Prediction of core targets and pathways of JWPTL against pain associated with endometriosis by protein-protein interaction(PPI)network work,gene ontology(GO),and Kyoto Encyclopedia of Genes and Genomes(KEGG)functional enrichment analysis.The Sprague-Dawley rat endometriosis model was constructed using the autologous endosomal transplantation method,and the successfully modeled rats were randomly divided into the model group and the JWPTL group,with 8 rats in each group.Another 8 rats were set up in the sham group.Rats in the JWPTL group used the rectal delivery method with the addition of JWPTL(7.77 g·kg^(-1)·d^(-1))once a day for 28 d.Rats in the model and sham-operated groups were given equal amounts of saline using the same administration method.The 50%paw withdrawal threshold(PWT)of the rats was measured at different time points.After the intervention,the expression of phosphatidylinositol 3-kinase(PI3K)and protein kinase B(Akt)proteins and mRNA in endometriotic tissues was detected by immuneohistochemistry and reverse transcription-polymerase chain reaction.RESULTS:From GeneCards,Online Mendelian Inheritance in Man and other databases,a total of 964 endometriosis(EMs)-related pain targets were screened,142 active ingredients of JWPTL,605 targets,and 221 potential targets were obtained by intersection of Venn diagram;44 core targets were identified by constructing PPI network.KEGG enrichment analysis showed that JWPTL mainly involves the PI3K-Akt signaling pathway,estrogen signaling pathway,hypoxia inducible factor-1 signaling pathway,tumour necrotizing factor signaling pathway,and other signaling pathways in the treatment of EMs-related pain.Animal experiments showed that JWPTL could up-regulate the mechanical pain threshold and reduce the expression of PI3K and Akt proteins and mRNA in ectopic endometrial tissues of model rats.CONCLUSIONS:The present study preliminarily analyzed the pharmacological mechanism of the formula,and molecular docking and animal experiments showed the feasibility of this study,suggesting that the formula may inhibit the release of inflammatory factors and reverse the pain associated with EMs by downregulating the PI3K/Akt signaling pathway.展开更多
1999年,旅美学者周勤如博士于美国创办大型英文音乐学报《音乐中国》(Journal of Masic in China),至今已24年。1980年,中央音乐学院杨儒怀教授在一次工作会议上曾谈到:“我们应该有一本介绍中国音乐学术的英文刊物。”这句话被周先生...1999年,旅美学者周勤如博士于美国创办大型英文音乐学报《音乐中国》(Journal of Masic in China),至今已24年。1980年,中央音乐学院杨儒怀教授在一次工作会议上曾谈到:“我们应该有一本介绍中国音乐学术的英文刊物。”这句话被周先生记住了。《中国音乐学》在1 989年、《黄钟》在1991年、《中央音乐学院学报》在1992年先后试办过英文专刊(1)。展开更多
文摘国际音乐感知与认知会议(International Conference on Music Perception and Cognition,简称ICMPC)始办于1989年,每两年一届,是目前音乐心理学领域最高规格的国际性学术会议。亚太地区音乐认知科学学会(The Asia-Pacific Society for the Cognitive Sciences of Music,简称APSCOM)1会议每三年举办一次,致力于促进亚太地区音乐认知科学的研究活动及深化亚太地区研究人员之间的交流和友谊。
基金Natural Science Foundation-funded Project:Exploring the Molecular Mechanism of Reversal of Pain in Endometriosis by Pentongling Formula based on Nerve Growth Factor/p38 mitogenactivated Protein Kinase Signaling Pathway(No.81674009)Construction of Traditional Chinese Medicine Inheritance and Innovation Development Demonstration Pilot Projects in Pudong New area-high-level Research-oriented Traditional Chinese Medicine Hospital Construction(No.YC-2023-0901)。
文摘OBJECTIVE:To investigate the effects and mechanisms of the Jiawei Pentongling formula(加味盆痛灵方,JWPTL)in treating endometriosis-related pain using network pharmacology study and experimental validation.METHODS:Active ingredients and relevant targets of JWPTL,as well as genes for endometriosis-related pain,were collected from public databases.Prediction of core targets and pathways of JWPTL against pain associated with endometriosis by protein-protein interaction(PPI)network work,gene ontology(GO),and Kyoto Encyclopedia of Genes and Genomes(KEGG)functional enrichment analysis.The Sprague-Dawley rat endometriosis model was constructed using the autologous endosomal transplantation method,and the successfully modeled rats were randomly divided into the model group and the JWPTL group,with 8 rats in each group.Another 8 rats were set up in the sham group.Rats in the JWPTL group used the rectal delivery method with the addition of JWPTL(7.77 g·kg^(-1)·d^(-1))once a day for 28 d.Rats in the model and sham-operated groups were given equal amounts of saline using the same administration method.The 50%paw withdrawal threshold(PWT)of the rats was measured at different time points.After the intervention,the expression of phosphatidylinositol 3-kinase(PI3K)and protein kinase B(Akt)proteins and mRNA in endometriotic tissues was detected by immuneohistochemistry and reverse transcription-polymerase chain reaction.RESULTS:From GeneCards,Online Mendelian Inheritance in Man and other databases,a total of 964 endometriosis(EMs)-related pain targets were screened,142 active ingredients of JWPTL,605 targets,and 221 potential targets were obtained by intersection of Venn diagram;44 core targets were identified by constructing PPI network.KEGG enrichment analysis showed that JWPTL mainly involves the PI3K-Akt signaling pathway,estrogen signaling pathway,hypoxia inducible factor-1 signaling pathway,tumour necrotizing factor signaling pathway,and other signaling pathways in the treatment of EMs-related pain.Animal experiments showed that JWPTL could up-regulate the mechanical pain threshold and reduce the expression of PI3K and Akt proteins and mRNA in ectopic endometrial tissues of model rats.CONCLUSIONS:The present study preliminarily analyzed the pharmacological mechanism of the formula,and molecular docking and animal experiments showed the feasibility of this study,suggesting that the formula may inhibit the release of inflammatory factors and reverse the pain associated with EMs by downregulating the PI3K/Akt signaling pathway.
文摘1999年,旅美学者周勤如博士于美国创办大型英文音乐学报《音乐中国》(Journal of Masic in China),至今已24年。1980年,中央音乐学院杨儒怀教授在一次工作会议上曾谈到:“我们应该有一本介绍中国音乐学术的英文刊物。”这句话被周先生记住了。《中国音乐学》在1 989年、《黄钟》在1991年、《中央音乐学院学报》在1992年先后试办过英文专刊(1)。
