Ni-based superalloys are one of the most important materials employed in high-temperature applications within the aerospace and nuclear energy industries and in gas turbines due to their excellent corrosion,radiation,...Ni-based superalloys are one of the most important materials employed in high-temperature applications within the aerospace and nuclear energy industries and in gas turbines due to their excellent corrosion,radiation,fatigue resistance,and high-temperature strength.Linear friction welding(LFW)is a new joining technology with near-net-forming characteristics that can be used for the manu-facture and repair of a wide range of aerospace components.This paper reviews published works on LFW of Ni-based superalloys with the aim of understanding the characteristics of frictional heat generation and extrusion deformation,microstructures,mechanical proper-ties,flash morphology,residual stresses,creep,and fatigue of Ni-based superalloy weldments produced with LFW to enable future optim-um utilization of the LFW process.展开更多
AIM:To explore the effect of visual perception learning software training(VPT)on binocular visual function reconstruction in children with intermittent exotropia after strabismus surgery.METHODS:Ninety children with i...AIM:To explore the effect of visual perception learning software training(VPT)on binocular visual function reconstruction in children with intermittent exotropia after strabismus surgery.METHODS:Ninety children with intermittent exotropia admitted to our hospital from June 2018 to December 2018 were included,and randomly divided into VPT and control groups.Children in the control group received basic binocular vision training,while those in the VPT group received VPT after strabismus surgery.Tertiary visual function,visual perception function,Newcastle Control Score(NCS),and ocular position retraction rate were compared at 3 and 12mo after the surgery.RESULTS:At 3 and 12mo after the surgery,the proportion of simultaneous perception,binocular fusion version and binocular stereo vision in the VPT group was conspicuously higher than that in the control group(P<0.05).After the vision training,the binocular visual perception functions of children in both groups were significantly improved compared with that before training(P<0.05).Interestingly,the grating sharpness,texture perception and texture motion perception in the VPT group were dramatically better than control group(P<0.01).The NCS in the VPT group was significantly lower than that in the control group(P<0.05).The ocular position retraction rate in the VPT group was significantly lower than that in the control group at 12mo(8.89%vs 26.67%,P=0.03).CONCLUSION:VPT effectively promotes binocular visual function reconstruction in intermittent exotropia children after strabismus surgery and reduces the strabismus severity and ocular position retraction rate.展开更多
Mobile location-based services(MLBS)refer to services around geographic location data.Mobile terminals use wireless communication networks(or satellite positioning systems)to obtain users’geographic location coordina...Mobile location-based services(MLBS)refer to services around geographic location data.Mobile terminals use wireless communication networks(or satellite positioning systems)to obtain users’geographic location coordinate information based on spatial databases and integrate with other information to provide users with required location-related services.The development of systems based on MLBS has significance and practical value.In this paper a visualization management information system for personnel in major events based on microservices,namely MEPMIS,is designed and implemented by using MLBS.The system consists of a server and a client app,and it has some functions including map search and query,personnel positioning and scheduling,location management,messaging,and location service.Managers of the events can quickly search and locate the staff on the specific area of the map in real-time,and make broadcasting messages to the staff,and manage the staff.The client app is developed on the Android system,by which staff users can send the positions information to the server timely.The client users can search fuzzily near their peers and list their locations,and also call near peers through sending messages or query the history record of staff locations.In the design of the system,several new proposed techniques,including visual annotation method for overlapping locations,correcting trajectory drift algorithm,microservices-based overall system architecture methodology and other new techniques,which are applied to the implementation of the system.Also,HTML5,JQuery,MLBS APIs(Application Program Interfaces)related programming techniques have been used and combined with loading Ajax asynchronously and Json data encapsulation,map marker optimization techniques,that can improve the positioning accuracy and the performance of the system.The developed system with practical functions can enhance the efficiencies of the organization and management of major events.展开更多
大规模风电、光伏新能源经交流送出系统中,送出线路发生故障后,新能源电源控制的故障响应严重影响交流线路距离保护的动作性能。该文分析了新能源电源典型控制策略对故障后电源等值阻抗及系统功角的影响,故障后电源等值阻抗和系统功角...大规模风电、光伏新能源经交流送出系统中,送出线路发生故障后,新能源电源控制的故障响应严重影响交流线路距离保护的动作性能。该文分析了新能源电源典型控制策略对故障后电源等值阻抗及系统功角的影响,故障后电源等值阻抗和系统功角显著增大。进一步研究了不同类型距离保护的动作性能。针对测距式距离保护,揭示了线路正向区外或反向区外发生经过渡电阻故障时保护误动、线路正向区内故障时保护拒动机理。针对比相式距离保护,揭示了正序极化电压相位受控偏移导致线路区内相间短路故障时保护拒动、区外反向故障时保护误动机理。利用实时数字仿真平台(real time digital simulation system,RTDS)建立了仿真模型,利用仿真结果和现场实际误动数据验证了理论分析的正确性,为大规模新能源送出线路故障分析和后备保护配置提供了理论依据。展开更多
To address the challenges associated with difficult casing running,limited annular space,and poor cementing quality in the completion of ultra-deep wells,the extreme line casing offers an effective solution over conve...To address the challenges associated with difficult casing running,limited annular space,and poor cementing quality in the completion of ultra-deep wells,the extreme line casing offers an effective solution over conventional casings.However,due to its smaller size,the joint strength of extreme line casing is reduced,which may cause failure when running in the hole.To address this issue,this study focuses on the CST-ZTΦ139.7 mm×7.72 mm extreme line casing and employs the elastic-plastic mechanics to establish a comprehensive analysis of the casing joint,taking into account the influence of geometric and material nonlinearities.A finite element model is developed to analyze the forces and deformations of the extreme line casing joint under axial tension and external collapse load.The model investigates the stress distribution of each thread tooth subjected to various tensile forces and external pressures.Additionally,the tensile strength and crushing strength of the extreme line casing joint are determined through both analytical and experimental approaches.The findings reveal that,under axial tensile load,the bearing surface of each thread tooth experiences uneven stress,with relatively high equivalent stress at the root of each thread tooth.The end thread teeth are valuable spots for failure.It is observed that the critical fracture axial load of thread decreases linearly with the increase of thread tooth sequence.Under external pressure,the circumferential stress is highest at the small end of the external thread,leading to yield deformation.The tensile strength of the joint obtained from the finite element model exhibits a relative error of less than 7%compared to the analytical and experimental values,proving the reliability of the finite element model.The tensile strength of the joint is 3091.9 k N.Moreover,in terms of anti-collapse capability,the joints demonstrate higher resistance to collapse compared to the casing body,which is consistent with the test results where the pipe body experiences collapse and failure while the joints remain intact during the experiment.The failure load of the casing body under external collapse pressure is 87.4 MPa.The present study provides a basic understanding of the mechanical strengths of extreme line casing joint.展开更多
Streamers represent an important stage in the initiation of gap discharge. In this work, we used an eight-frame intensified charge-coupled device camera to capture the streamer development process when a lightning imp...Streamers represent an important stage in the initiation of gap discharge. In this work, we used an eight-frame intensified charge-coupled device camera to capture the streamer development process when a lightning impulse voltage of 95%–100% U50% was applied in a 3 m rod–plate gap and the streamer velocity was analyzed. Analysis of the observations shows that streamer velocity can be defined by three stages: rapid velocity decline(stage 1), rapid velocity rise(stage 2)and slow velocity decline(stage 3). The effects of electrode shape, applied voltage and gap breakdown or withstanding on streamer velocity were analyzed. The electrode with a larger radius of curvature will result in a higher initial velocity, and a higher voltage amplitude will cause the streamer to propagate faster at stage 3. Gap withstanding or breakdown has no obvious effect on streamer velocity. In addition, the experimental results are compared with previous results and the statistical characteristics of the primary streamer discharge are discussed.展开更多
新能源电源经柔性直流输电线路接入交流系统已经成为电力系统中的典型场景。以基于模块化多电平换流器的柔性直流(modular multilevel converter-high voltage direct current,MMC-HVDC)受端交流线路配置的正序电压为极化电压的比相式...新能源电源经柔性直流输电线路接入交流系统已经成为电力系统中的典型场景。以基于模块化多电平换流器的柔性直流(modular multilevel converter-high voltage direct current,MMC-HVDC)受端交流线路配置的正序电压为极化电压的比相式距离保护为研究对象,结合受端换流器的控制策略,分析了新能源经柔性高压直送出系统中柔直受端交流线路发生短路故障场景下该保护的适应性:在发生相间金属性短路故障情况下,距离保护存在区内短路拒动以及反向区外短路误动的风险。为探究保护不正确动作机制,首先在电压平面上分析了参量变化对距离保护动作行为的影响,揭示了距离保护内在的系统功角与短路容量约束,推导了距离保护正确动作的功角边界。通过将柔直侧系统进行合理等值,受端交流线路发生相间金属性短路故障后,受端换流器控制策略使得系统等值功角增大,距离保护特性位于动作边界,存在拒动/误动风险。利用RTDS建立了风电经柔直送出系统的仿真模型,分析了受端交流线路故障后系统的等值功角特征,验证了距离保护的不正确动作特性。展开更多
We investigate the variation induced in long-period stacking ordered(LPSO)structures,dynamic recrystallization(DRX),and mechanical performance of hot-extruded Mg89Y4Zn2Li5 alloys fabricated at different extrusion spee...We investigate the variation induced in long-period stacking ordered(LPSO)structures,dynamic recrystallization(DRX),and mechanical performance of hot-extruded Mg89Y4Zn2Li5 alloys fabricated at different extrusion speeds(Ve=0.4,0.8,1.0,1.2 mm/s)and die angles(α=30°,60°,90°)under 400℃,the dissolution and reprecipitation of 14H LPSO structure accompanied by DRX process are then clarified in detail.Upon all extrusion conditions,the block 18R LPSO structures elongate in the extrusion direction,while the lamellar 14H LPSO structures dissolve under the deformation strain.In addition,due to discontinuous and continuous DRX mechanisms,all hot-extruded alloys have a full DRX microstructure consisting of equiaxed recrystallized grains,but the DRX grain size reduces when both extrusion speed and die angle decrease.Note that,in the interior of DRX grains,thin LPSO lamellae mixing 14H,18R and 24R structures nucleate and dynamically precipitate due to the dissolution of the original lamellar 14H LPSO structures.Furthermore,the hot-extruded Mg_(89)Y_(4)Zn_(2)Li_(5)alloy becomes stronger as decreasing of the extrusion speed and die angle,whereas the ductility remains nearly constant.Finally,the hotextruded Mg_(89)Y_(4)Zn_(2)Li_(5)alloy achieves an excellent strength-ductility balance at a relatively low extrusion speed(0.4 mm/s)and small die angle(30°)mainly due to the elongated 18R LPSO structure,fine and full DRX microstructure,thin mixed LPSO precipitates in the DRX grains,twins and dislocations.展开更多
BACKGROUND Acute pancreatitis(AP)is a disease featuring acute inflammation of the pancreas and histological destruction of acinar cells.Approximately 20%of AP patients progress to moderately severe or severe pancreati...BACKGROUND Acute pancreatitis(AP)is a disease featuring acute inflammation of the pancreas and histological destruction of acinar cells.Approximately 20%of AP patients progress to moderately severe or severe pancreatitis,with a case fatality rate of up to 30%.However,a single indicator that can serve as the gold standard for prognostic prediction has not been discovered.Therefore,gaining deeper insights into the underlying mechanism of AP progression and the evolution of the disease and exploring effective biomarkers are important for early diagnosis,progression evaluation,and precise treatment of AP.AIM To determine the regulatory mechanisms of tRNA-derived fragments(tRFs)in AP based on small RNA sequencing and experiments.METHODS Small RNA sequencing and functional enrichment analyses were performed to identify key tRFs and the potential mechanisms in AP.Reverse transcription quantitative polymerase chain reaction(RT-qPCR)was conducted to determine tRF expression.AP cell and mouse models were created to investigate the role of tRF36 in AP progression.Lipase,amylase,and cytokine levels were assayed to examine AP progression.Ferritin expression,reactive oxygen species,malondialdehyde,and ferric ion levels were assayed to evaluate cellular ferroptosis.RNA pull down assays and methylated RNA immunoprecipitation were performed to explore the molecular mechanisms.RESULTS RT-qPCR results showed that tRF36 was significantly upregulated in the serum of AP patients,compared to healthy controls.Functional enrichment analysis indicated that target genes of tRF36 were involved in ferroptosisrelated pathways,including the Hippo signaling pathway and ion transport.Moreover,the occurrence of pancreatic cell ferroptosis was detected in AP cells and mouse models.The results of interference experiments and AP cell models suggested that tRF-36 could promote AP progression through the regulation of ferroptosis.Furthermore,ferroptosis gene microarray,database prediction,and immunoprecipitation suggested that tRF-36 accelerated the progression of AP by recruiting insulin-like growth factor 2 mRNA binding protein 3(IGF2BP3)to the p53 mRNA m6A modification site by binding to IGF2BP3,which enhanced p53 mRNA stability and promoted the ferroptosis of pancreatic follicle cells.CONCLUSION In conclusion,regulation of nuclear pre-mRNA domain-containing protein 1B promoted AP development by regulating the ferroptosis of pancreatic cells,thereby acting as a prospective therapeutic target for AP.In addition,this study provided a basis for understanding the regulatory mechanisms of tRFs in AP.展开更多
Zero-emission eco-friendly vehicles with partly or fully electric powertrains have exhibited rapidly increased demand for reducing the emissions of air pollutants and improving the energy efficiency. Advanced catalyti...Zero-emission eco-friendly vehicles with partly or fully electric powertrains have exhibited rapidly increased demand for reducing the emissions of air pollutants and improving the energy efficiency. Advanced catalytic and energy materials are essential as the significant portions in the key technologies of eco-friendly vehicles, such as the exhaust emission control system,power lithium ion battery and hydrogen fuel cell. Precise synthesis and surface modification of the functional materials and electrodes are required to satisfy the efficient surface and interface catalysis, as well as rapid electron/ion transport. Atomic layer deposition(ALD), an atomic and close-to-atomic scale manufacturing method, shows unique characteristics of precise thickness control, uniformity and conformality for film deposition, which has emerged as an important technique to design and engineer advanced catalytic and energy materials. This review has summarized recent process of ALD on the controllable preparation and modification of metal and oxide catalysts, as well as lithium ion battery and fuel cell electrodes. The enhanced catalytic and electrochemical performances are discussed with the unique nanostructures prepared by ALD. Recent works on ALD reactors for mass production are highlighted. The challenges involved in the research and development of ALD on the future practical applications are presented, including precursor and deposition process investigation, practical device performance evaluation, large-scale and efficient production, etc.展开更多
The current study of minimum quantity lubrication(MQL)concentrates on its performance improvement.By contrast with nanofluid MQL and electrostatic atomization(EA),the proposed nanofluid composite electrostatic sprayin...The current study of minimum quantity lubrication(MQL)concentrates on its performance improvement.By contrast with nanofluid MQL and electrostatic atomization(EA),the proposed nanofluid composite electrostatic spraying(NCES)can enhance the performance of MQL more comprehensively.However,it is largely influenced by the base fluid of external fluid.In this paper,the lubrication property and machining performance of NCES with different types of vegetable oils(castor,palm,soybean,rapeseed,and LB2000 oil)as the base fluids of external fluid were compared and evaluated by friction and milling tests under different flow ratios of external and internal fluids.The spraying current and electrowetting angle were tested to analyze the influence of vegetable oil type as the base fluid of external fluid on NCES performances.The friction test results show that relative to NCES with other vegetable oils as the base fluids of external fluid,NCES with LB2000 as the base fluid of external fluid reduced the friction coefficient and wear loss by 9.4%-27.7%and 7.6%-26.5%,respectively.The milling test results display that the milling force and milling temperature for NCES with LB2000 as the base fluid of external fluid were 1.4%-13.2%and 3.6%-11.2%lower than those for NCES with other vegetable oils as the base fluids of external fluid,respectively.When LB2000/multi-walled carbon nanotube(MWCNT)water-based nanofluid was used as the external/internal fluid and the flow ratio of external and internal fluids was 2:1,NCES showed the best milling performance.This study provides theoretical and technical support for the selection of the base fluid of NCES external fluid.展开更多
基金supported by the National Natural Science Foundation of China(Nos.52074228,52305420,and 51875470)the China Postdoctoral Science Foundation(No.2023M742830)the Xi’an Beilin District Science and Technology Planning Project,China(No.GX2349).
文摘Ni-based superalloys are one of the most important materials employed in high-temperature applications within the aerospace and nuclear energy industries and in gas turbines due to their excellent corrosion,radiation,fatigue resistance,and high-temperature strength.Linear friction welding(LFW)is a new joining technology with near-net-forming characteristics that can be used for the manu-facture and repair of a wide range of aerospace components.This paper reviews published works on LFW of Ni-based superalloys with the aim of understanding the characteristics of frictional heat generation and extrusion deformation,microstructures,mechanical proper-ties,flash morphology,residual stresses,creep,and fatigue of Ni-based superalloy weldments produced with LFW to enable future optim-um utilization of the LFW process.
文摘AIM:To explore the effect of visual perception learning software training(VPT)on binocular visual function reconstruction in children with intermittent exotropia after strabismus surgery.METHODS:Ninety children with intermittent exotropia admitted to our hospital from June 2018 to December 2018 were included,and randomly divided into VPT and control groups.Children in the control group received basic binocular vision training,while those in the VPT group received VPT after strabismus surgery.Tertiary visual function,visual perception function,Newcastle Control Score(NCS),and ocular position retraction rate were compared at 3 and 12mo after the surgery.RESULTS:At 3 and 12mo after the surgery,the proportion of simultaneous perception,binocular fusion version and binocular stereo vision in the VPT group was conspicuously higher than that in the control group(P<0.05).After the vision training,the binocular visual perception functions of children in both groups were significantly improved compared with that before training(P<0.05).Interestingly,the grating sharpness,texture perception and texture motion perception in the VPT group were dramatically better than control group(P<0.01).The NCS in the VPT group was significantly lower than that in the control group(P<0.05).The ocular position retraction rate in the VPT group was significantly lower than that in the control group at 12mo(8.89%vs 26.67%,P=0.03).CONCLUSION:VPT effectively promotes binocular visual function reconstruction in intermittent exotropia children after strabismus surgery and reduces the strabismus severity and ocular position retraction rate.
基金The work is supported by the Tianjin Planning Project of Philosophy and Social Science under Grant No.TJGL20-018 for Dr.L.J.Hou of Tianjin Normal University,China。
文摘Mobile location-based services(MLBS)refer to services around geographic location data.Mobile terminals use wireless communication networks(or satellite positioning systems)to obtain users’geographic location coordinate information based on spatial databases and integrate with other information to provide users with required location-related services.The development of systems based on MLBS has significance and practical value.In this paper a visualization management information system for personnel in major events based on microservices,namely MEPMIS,is designed and implemented by using MLBS.The system consists of a server and a client app,and it has some functions including map search and query,personnel positioning and scheduling,location management,messaging,and location service.Managers of the events can quickly search and locate the staff on the specific area of the map in real-time,and make broadcasting messages to the staff,and manage the staff.The client app is developed on the Android system,by which staff users can send the positions information to the server timely.The client users can search fuzzily near their peers and list their locations,and also call near peers through sending messages or query the history record of staff locations.In the design of the system,several new proposed techniques,including visual annotation method for overlapping locations,correcting trajectory drift algorithm,microservices-based overall system architecture methodology and other new techniques,which are applied to the implementation of the system.Also,HTML5,JQuery,MLBS APIs(Application Program Interfaces)related programming techniques have been used and combined with loading Ajax asynchronously and Json data encapsulation,map marker optimization techniques,that can improve the positioning accuracy and the performance of the system.The developed system with practical functions can enhance the efficiencies of the organization and management of major events.
文摘大规模风电、光伏新能源经交流送出系统中,送出线路发生故障后,新能源电源控制的故障响应严重影响交流线路距离保护的动作性能。该文分析了新能源电源典型控制策略对故障后电源等值阻抗及系统功角的影响,故障后电源等值阻抗和系统功角显著增大。进一步研究了不同类型距离保护的动作性能。针对测距式距离保护,揭示了线路正向区外或反向区外发生经过渡电阻故障时保护误动、线路正向区内故障时保护拒动机理。针对比相式距离保护,揭示了正序极化电压相位受控偏移导致线路区内相间短路故障时保护拒动、区外反向故障时保护误动机理。利用实时数字仿真平台(real time digital simulation system,RTDS)建立了仿真模型,利用仿真结果和现场实际误动数据验证了理论分析的正确性,为大规模新能源送出线路故障分析和后备保护配置提供了理论依据。
基金financially supported by National Natural Science foundation of China(Grant No.52104006)Science and Technology Cooperation Project of the CNPC-SWPU Innovation Alliance(Grant No.2020CX040202)。
文摘To address the challenges associated with difficult casing running,limited annular space,and poor cementing quality in the completion of ultra-deep wells,the extreme line casing offers an effective solution over conventional casings.However,due to its smaller size,the joint strength of extreme line casing is reduced,which may cause failure when running in the hole.To address this issue,this study focuses on the CST-ZTΦ139.7 mm×7.72 mm extreme line casing and employs the elastic-plastic mechanics to establish a comprehensive analysis of the casing joint,taking into account the influence of geometric and material nonlinearities.A finite element model is developed to analyze the forces and deformations of the extreme line casing joint under axial tension and external collapse load.The model investigates the stress distribution of each thread tooth subjected to various tensile forces and external pressures.Additionally,the tensile strength and crushing strength of the extreme line casing joint are determined through both analytical and experimental approaches.The findings reveal that,under axial tensile load,the bearing surface of each thread tooth experiences uneven stress,with relatively high equivalent stress at the root of each thread tooth.The end thread teeth are valuable spots for failure.It is observed that the critical fracture axial load of thread decreases linearly with the increase of thread tooth sequence.Under external pressure,the circumferential stress is highest at the small end of the external thread,leading to yield deformation.The tensile strength of the joint obtained from the finite element model exhibits a relative error of less than 7%compared to the analytical and experimental values,proving the reliability of the finite element model.The tensile strength of the joint is 3091.9 k N.Moreover,in terms of anti-collapse capability,the joints demonstrate higher resistance to collapse compared to the casing body,which is consistent with the test results where the pipe body experiences collapse and failure while the joints remain intact during the experiment.The failure load of the casing body under external collapse pressure is 87.4 MPa.The present study provides a basic understanding of the mechanical strengths of extreme line casing joint.
基金supported by the Beijing Science Fund for Distinguished Young Scholars(No.JQ22009)National Natural Science Foundation of China(No.51977198)。
文摘Streamers represent an important stage in the initiation of gap discharge. In this work, we used an eight-frame intensified charge-coupled device camera to capture the streamer development process when a lightning impulse voltage of 95%–100% U50% was applied in a 3 m rod–plate gap and the streamer velocity was analyzed. Analysis of the observations shows that streamer velocity can be defined by three stages: rapid velocity decline(stage 1), rapid velocity rise(stage 2)and slow velocity decline(stage 3). The effects of electrode shape, applied voltage and gap breakdown or withstanding on streamer velocity were analyzed. The electrode with a larger radius of curvature will result in a higher initial velocity, and a higher voltage amplitude will cause the streamer to propagate faster at stage 3. Gap withstanding or breakdown has no obvious effect on streamer velocity. In addition, the experimental results are compared with previous results and the statistical characteristics of the primary streamer discharge are discussed.
文摘新能源电源经柔性直流输电线路接入交流系统已经成为电力系统中的典型场景。以基于模块化多电平换流器的柔性直流(modular multilevel converter-high voltage direct current,MMC-HVDC)受端交流线路配置的正序电压为极化电压的比相式距离保护为研究对象,结合受端换流器的控制策略,分析了新能源经柔性高压直送出系统中柔直受端交流线路发生短路故障场景下该保护的适应性:在发生相间金属性短路故障情况下,距离保护存在区内短路拒动以及反向区外短路误动的风险。为探究保护不正确动作机制,首先在电压平面上分析了参量变化对距离保护动作行为的影响,揭示了距离保护内在的系统功角与短路容量约束,推导了距离保护正确动作的功角边界。通过将柔直侧系统进行合理等值,受端交流线路发生相间金属性短路故障后,受端换流器控制策略使得系统等值功角增大,距离保护特性位于动作边界,存在拒动/误动风险。利用RTDS建立了风电经柔直送出系统的仿真模型,分析了受端交流线路故障后系统的等值功角特征,验证了距离保护的不正确动作特性。
基金the assistance from the Provincial and Ministry Collaborative Innovation Center of Development and Application of High-Performance Aluminum/Magnesium Alloy Materialsthe financial supports from the Research Project Supported by Shanxi Scholarship Council of China(No.2021-125)Natural Science Foundation of Shanxi Province(No.20210302124631).
文摘We investigate the variation induced in long-period stacking ordered(LPSO)structures,dynamic recrystallization(DRX),and mechanical performance of hot-extruded Mg89Y4Zn2Li5 alloys fabricated at different extrusion speeds(Ve=0.4,0.8,1.0,1.2 mm/s)and die angles(α=30°,60°,90°)under 400℃,the dissolution and reprecipitation of 14H LPSO structure accompanied by DRX process are then clarified in detail.Upon all extrusion conditions,the block 18R LPSO structures elongate in the extrusion direction,while the lamellar 14H LPSO structures dissolve under the deformation strain.In addition,due to discontinuous and continuous DRX mechanisms,all hot-extruded alloys have a full DRX microstructure consisting of equiaxed recrystallized grains,but the DRX grain size reduces when both extrusion speed and die angle decrease.Note that,in the interior of DRX grains,thin LPSO lamellae mixing 14H,18R and 24R structures nucleate and dynamically precipitate due to the dissolution of the original lamellar 14H LPSO structures.Furthermore,the hot-extruded Mg_(89)Y_(4)Zn_(2)Li_(5)alloy becomes stronger as decreasing of the extrusion speed and die angle,whereas the ductility remains nearly constant.Finally,the hotextruded Mg_(89)Y_(4)Zn_(2)Li_(5)alloy achieves an excellent strength-ductility balance at a relatively low extrusion speed(0.4 mm/s)and small die angle(30°)mainly due to the elongated 18R LPSO structure,fine and full DRX microstructure,thin mixed LPSO precipitates in the DRX grains,twins and dislocations.
基金the National Natural Science Foundation of China,No.81860424.
文摘BACKGROUND Acute pancreatitis(AP)is a disease featuring acute inflammation of the pancreas and histological destruction of acinar cells.Approximately 20%of AP patients progress to moderately severe or severe pancreatitis,with a case fatality rate of up to 30%.However,a single indicator that can serve as the gold standard for prognostic prediction has not been discovered.Therefore,gaining deeper insights into the underlying mechanism of AP progression and the evolution of the disease and exploring effective biomarkers are important for early diagnosis,progression evaluation,and precise treatment of AP.AIM To determine the regulatory mechanisms of tRNA-derived fragments(tRFs)in AP based on small RNA sequencing and experiments.METHODS Small RNA sequencing and functional enrichment analyses were performed to identify key tRFs and the potential mechanisms in AP.Reverse transcription quantitative polymerase chain reaction(RT-qPCR)was conducted to determine tRF expression.AP cell and mouse models were created to investigate the role of tRF36 in AP progression.Lipase,amylase,and cytokine levels were assayed to examine AP progression.Ferritin expression,reactive oxygen species,malondialdehyde,and ferric ion levels were assayed to evaluate cellular ferroptosis.RNA pull down assays and methylated RNA immunoprecipitation were performed to explore the molecular mechanisms.RESULTS RT-qPCR results showed that tRF36 was significantly upregulated in the serum of AP patients,compared to healthy controls.Functional enrichment analysis indicated that target genes of tRF36 were involved in ferroptosisrelated pathways,including the Hippo signaling pathway and ion transport.Moreover,the occurrence of pancreatic cell ferroptosis was detected in AP cells and mouse models.The results of interference experiments and AP cell models suggested that tRF-36 could promote AP progression through the regulation of ferroptosis.Furthermore,ferroptosis gene microarray,database prediction,and immunoprecipitation suggested that tRF-36 accelerated the progression of AP by recruiting insulin-like growth factor 2 mRNA binding protein 3(IGF2BP3)to the p53 mRNA m6A modification site by binding to IGF2BP3,which enhanced p53 mRNA stability and promoted the ferroptosis of pancreatic follicle cells.CONCLUSION In conclusion,regulation of nuclear pre-mRNA domain-containing protein 1B promoted AP development by regulating the ferroptosis of pancreatic cells,thereby acting as a prospective therapeutic target for AP.In addition,this study provided a basis for understanding the regulatory mechanisms of tRFs in AP.
基金supported by the National Key R&D Program of China (2020YFB2010401 and 2022YFF1500400)National Natural Science Foundation of China (51835005and 52271216)+2 种基金Hubei Province Natural Science Foundation for Innovative Research Group (2020CFA030)Fundamental Research Funds for the Central Universities,HUST(2020kfy XJJS100)Tencent Foundation。
文摘Zero-emission eco-friendly vehicles with partly or fully electric powertrains have exhibited rapidly increased demand for reducing the emissions of air pollutants and improving the energy efficiency. Advanced catalytic and energy materials are essential as the significant portions in the key technologies of eco-friendly vehicles, such as the exhaust emission control system,power lithium ion battery and hydrogen fuel cell. Precise synthesis and surface modification of the functional materials and electrodes are required to satisfy the efficient surface and interface catalysis, as well as rapid electron/ion transport. Atomic layer deposition(ALD), an atomic and close-to-atomic scale manufacturing method, shows unique characteristics of precise thickness control, uniformity and conformality for film deposition, which has emerged as an important technique to design and engineer advanced catalytic and energy materials. This review has summarized recent process of ALD on the controllable preparation and modification of metal and oxide catalysts, as well as lithium ion battery and fuel cell electrodes. The enhanced catalytic and electrochemical performances are discussed with the unique nanostructures prepared by ALD. Recent works on ALD reactors for mass production are highlighted. The challenges involved in the research and development of ALD on the future practical applications are presented, including precursor and deposition process investigation, practical device performance evaluation, large-scale and efficient production, etc.
基金Supported by National Natural Science Foundation of China(Grant Nos.52175411 and 51205177)Jiangsu Provincial Natural Science Foundation(Grant Nos.BK20171307 and BK2012277).
文摘The current study of minimum quantity lubrication(MQL)concentrates on its performance improvement.By contrast with nanofluid MQL and electrostatic atomization(EA),the proposed nanofluid composite electrostatic spraying(NCES)can enhance the performance of MQL more comprehensively.However,it is largely influenced by the base fluid of external fluid.In this paper,the lubrication property and machining performance of NCES with different types of vegetable oils(castor,palm,soybean,rapeseed,and LB2000 oil)as the base fluids of external fluid were compared and evaluated by friction and milling tests under different flow ratios of external and internal fluids.The spraying current and electrowetting angle were tested to analyze the influence of vegetable oil type as the base fluid of external fluid on NCES performances.The friction test results show that relative to NCES with other vegetable oils as the base fluids of external fluid,NCES with LB2000 as the base fluid of external fluid reduced the friction coefficient and wear loss by 9.4%-27.7%and 7.6%-26.5%,respectively.The milling test results display that the milling force and milling temperature for NCES with LB2000 as the base fluid of external fluid were 1.4%-13.2%and 3.6%-11.2%lower than those for NCES with other vegetable oils as the base fluids of external fluid,respectively.When LB2000/multi-walled carbon nanotube(MWCNT)water-based nanofluid was used as the external/internal fluid and the flow ratio of external and internal fluids was 2:1,NCES showed the best milling performance.This study provides theoretical and technical support for the selection of the base fluid of NCES external fluid.