目的探究集成式训练对老年脑卒中患者平衡能力及抗跌倒风险的影响.方法选取2020年7月至2021年3月于南宁市第一人民医院收治的100例老年脑卒中患者为研究对象,并将其随机分为两组,对照组50例、实验组50例.其中,对照组选用个性化药物治疗...目的探究集成式训练对老年脑卒中患者平衡能力及抗跌倒风险的影响.方法选取2020年7月至2021年3月于南宁市第一人民医院收治的100例老年脑卒中患者为研究对象,并将其随机分为两组,对照组50例、实验组50例.其中,对照组选用个性化药物治疗并加入预防跌倒的指导及宣教,实验组则是在对照组的基础上实施集成式训练.对比两组的中文版Morse跌倒评估量表(Morse Fall Scale,MFS)、Berg平衡量表(Berg Balance Scale,BBS)、计时起立-步行测验(Timed Up and Go Test,TUGT)、跌倒发生率的情况变化.结果训练后第8周、6、12个月,两组的BBS评分有所升高,MFS评分、TUGT评分有所下降,且实验组情况较对照组改善良好(P<0.001).与对照组相比,实验组在训练12个月内跌倒发生率有所下降(P<0.05).结论通过集成式训练,可有助于改善老年脑卒中患者的平衡能力,降低跌倒的风险,减少跌倒发生率,以促进病情加快恢复.展开更多
鸡球虫病是一种由艾美耳属原生动物寄生虫引起的肠道疾病,是影响家禽业的最重要疾病之一。目前,球虫病的控制主要依赖于抗球虫药物的使用,但由于药物的长期广泛使用导致了球虫的严重耐药性。为研究其耐药性机制,本实验室前期对柔嫩艾美...鸡球虫病是一种由艾美耳属原生动物寄生虫引起的肠道疾病,是影响家禽业的最重要疾病之一。目前,球虫病的控制主要依赖于抗球虫药物的使用,但由于药物的长期广泛使用导致了球虫的严重耐药性。为研究其耐药性机制,本实验室前期对柔嫩艾美耳球虫敏感株、地克珠利耐药株、马杜拉霉素耐药株、盐霉素耐药株进行了转录组测序分析,发现与敏感株相比,柔嫩艾美耳球虫微管蛋白β链(Et TBC)仅在地克珠利耐药株高表达。本研究在此基础上,克隆、表达了EtTBC,并初步分析了其功能及与地克珠利的关系;以柔嫩艾美耳球虫敏感株cDNA为模板成功克隆了EtTBC基因,构建了原核表达重组质粒pET28a-Et TBC,并成功诱导表达了重组蛋白r Et TBC;利用qPCR对柔嫩艾美耳球虫敏感株不同发育阶段以及不同虫株(耐药株、敏感株和田间耐药株)的mRNA转录水平进行了分析,结果显示,该基因的转录水平在敏感株未孢子化卵囊阶段最高,且其mRNA转录水平仅在地克珠利耐药株上调;间接免疫荧光定位结果表明该蛋白主要分布在子孢子除折光体外的细胞质和表面,第二代裂殖子的细胞质和表面。展开更多
Invar合金是制备精细金属掩模板(Fine Metal Mask,简称FMM)的重要基材,其纯净度直接影响FMM的质量以及有机发光二极管(Organic Light EmittingDiode,简称OLED)技术的发展水平。首先概述了FMM的主要制备技术,介绍了对FMM基材Invar合金的...Invar合金是制备精细金属掩模板(Fine Metal Mask,简称FMM)的重要基材,其纯净度直接影响FMM的质量以及有机发光二极管(Organic Light EmittingDiode,简称OLED)技术的发展水平。首先概述了FMM的主要制备技术,介绍了对FMM基材Invar合金的质量要求,并对国产Invar合金箔和国外进口Invar合金箔内的夹杂物进行了表征分析。结果表明,国产Invar合金箔的纯净度与进口Invar合金箔相比,仍存在很大的差距,主要体现在夹杂物的尺寸和数量等方面。为实现OLED配套产业全国产化,攻克Invar合金的近零夹杂难题,开发新型制备技术是关键突破点。最后详细论述了超重力技术在Invar合金除杂方面的研究成果和电铸Invar合金箔应用的可行性,并指出超重力技术和电铸技术有望解决近零夹杂金属材料的制备难题。展开更多
Spinel cobalt oxide(Co_(3)O_(4)),consisting of tetrahedral Co^(2+)(CoTd)and octahedral Co^(3+)(CoOh),is considered as promising earth-abundant electrocatalyst for chlorine evolution reaction(CER).Identifying the catal...Spinel cobalt oxide(Co_(3)O_(4)),consisting of tetrahedral Co^(2+)(CoTd)and octahedral Co^(3+)(CoOh),is considered as promising earth-abundant electrocatalyst for chlorine evolution reaction(CER).Identifying the catalytic contribution of geometric Co site in the electrocatalytic CER plays a pivotal role to precisely modulate electronic configuration of active Co sites to boost CER.Herein,combining density functional theory calculations and experiment results assisted with operando analysis,we found that the Co_(Oh) site acts as the main active site for CER in spinel Co_(3)O_(4),which shows better Cl^(-)adsorption and more moderate intermediate adsorption toward CER than CoTd site,and does not undergo redox transition under CER condition at applied potentials.Guided by above findings,the oxygen vacancies were further introduced into the Co_(3)O_(4) to precisely manipulate the electronic configuration of Co_(Oh) to boost Cl^(-)adsorption and optimize the reaction path of CER and thus to enhance the intrinsic CER activity significantly.Our work figures out the importance of geometric configuration dependent CER activity,shedding light on the rational design of advanced electrocatalysts from geometric configuration optimization at the atomic level.展开更多
目的系统评价护士妊娠期临床工作体验和感受。方法检索PubMed、CINAHL、Embase、Web of Science、Cochrane Library、PsycInfo、CBM、中国知网、万方、维普数据库,筛选有关护士妊娠期临床工作体验的质性研究,检索时限为建库至2023年1月...目的系统评价护士妊娠期临床工作体验和感受。方法检索PubMed、CINAHL、Embase、Web of Science、Cochrane Library、PsycInfo、CBM、中国知网、万方、维普数据库,筛选有关护士妊娠期临床工作体验的质性研究,检索时限为建库至2023年1月。采用Meta整合方法对结果进行整合分析。结果共纳入12篇文献,提炼出38个研究结果,归纳成6个新类别,综合成3个整合结果:疲倦且交瘁的身心感受;打破原有工作状态及职业规划;多元应对与切身感悟。结论亟需关切妊娠期护士紊乱的身心体验,协助其调适工作状态,系统管理其职业学习及生涯;加强切实的政策管理,巩固妊娠期护士多元支持。展开更多
The Jiao Tong University Spectroscopic Telescope(JUST)is a 4.4-meter f/6.0 segmented-mirror telescope dedicated to spectroscopic observations.The JUST primary mirror is composed of 18 hexagonal segments,each with a di...The Jiao Tong University Spectroscopic Telescope(JUST)is a 4.4-meter f/6.0 segmented-mirror telescope dedicated to spectroscopic observations.The JUST primary mirror is composed of 18 hexagonal segments,each with a diameter of 1.1 m.JUST provides two Nasmyth platforms for placing science instruments.One Nasmyth focus fits a field of view of 10′and the other has an extended field of view of 1.2°with correction optics.A tertiary mirror is used to switch between the two Nasmyth foci.JUST will be installed at a site at Lenghu in Qinghai Province,China,and will conduct spectroscopic observations with three types of instruments to explore the dark universe,trace the dynamic universe,and search for exoplanets:(1)a multi-fiber(2000 fibers)medium-resolution spectrometer(R=4000-5000)to spectroscopically map galaxies and large-scale structure;(2)an integral field unit(IFU)array of 500 optical fibers and/or a long-slit spectrograph dedicated to fast follow-ups of transient sources for multi-messenger astronomy;(3)a high-resolution spectrometer(R~100000)designed to identify Jupiter analogs and Earth-like planets,with the capability to characterize the atmospheres of hot exoplanets.展开更多
文摘目的探究集成式训练对老年脑卒中患者平衡能力及抗跌倒风险的影响.方法选取2020年7月至2021年3月于南宁市第一人民医院收治的100例老年脑卒中患者为研究对象,并将其随机分为两组,对照组50例、实验组50例.其中,对照组选用个性化药物治疗并加入预防跌倒的指导及宣教,实验组则是在对照组的基础上实施集成式训练.对比两组的中文版Morse跌倒评估量表(Morse Fall Scale,MFS)、Berg平衡量表(Berg Balance Scale,BBS)、计时起立-步行测验(Timed Up and Go Test,TUGT)、跌倒发生率的情况变化.结果训练后第8周、6、12个月,两组的BBS评分有所升高,MFS评分、TUGT评分有所下降,且实验组情况较对照组改善良好(P<0.001).与对照组相比,实验组在训练12个月内跌倒发生率有所下降(P<0.05).结论通过集成式训练,可有助于改善老年脑卒中患者的平衡能力,降低跌倒的风险,减少跌倒发生率,以促进病情加快恢复.
文摘鸡球虫病是一种由艾美耳属原生动物寄生虫引起的肠道疾病,是影响家禽业的最重要疾病之一。目前,球虫病的控制主要依赖于抗球虫药物的使用,但由于药物的长期广泛使用导致了球虫的严重耐药性。为研究其耐药性机制,本实验室前期对柔嫩艾美耳球虫敏感株、地克珠利耐药株、马杜拉霉素耐药株、盐霉素耐药株进行了转录组测序分析,发现与敏感株相比,柔嫩艾美耳球虫微管蛋白β链(Et TBC)仅在地克珠利耐药株高表达。本研究在此基础上,克隆、表达了EtTBC,并初步分析了其功能及与地克珠利的关系;以柔嫩艾美耳球虫敏感株cDNA为模板成功克隆了EtTBC基因,构建了原核表达重组质粒pET28a-Et TBC,并成功诱导表达了重组蛋白r Et TBC;利用qPCR对柔嫩艾美耳球虫敏感株不同发育阶段以及不同虫株(耐药株、敏感株和田间耐药株)的mRNA转录水平进行了分析,结果显示,该基因的转录水平在敏感株未孢子化卵囊阶段最高,且其mRNA转录水平仅在地克珠利耐药株上调;间接免疫荧光定位结果表明该蛋白主要分布在子孢子除折光体外的细胞质和表面,第二代裂殖子的细胞质和表面。
基金Supported by the National Key Research and Development Program of China(2022YFA1404602)the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB0580000)+4 种基金the Key Deployment Projects of the Chinese Academy of Sciences(ZDRW-XH-2021-7-1)the National Natural Science Foundation of China(61975223,61991442,62305362,62075230)the Program of Shanghai Academic/Technology Research Leader(22XD1424400)the Shanghai Municipal Science and Technology Major Project(2019SHZDZX01)Natural Science Foundation of Shanghai(19ZR1465400)。
文摘Invar合金是制备精细金属掩模板(Fine Metal Mask,简称FMM)的重要基材,其纯净度直接影响FMM的质量以及有机发光二极管(Organic Light EmittingDiode,简称OLED)技术的发展水平。首先概述了FMM的主要制备技术,介绍了对FMM基材Invar合金的质量要求,并对国产Invar合金箔和国外进口Invar合金箔内的夹杂物进行了表征分析。结果表明,国产Invar合金箔的纯净度与进口Invar合金箔相比,仍存在很大的差距,主要体现在夹杂物的尺寸和数量等方面。为实现OLED配套产业全国产化,攻克Invar合金的近零夹杂难题,开发新型制备技术是关键突破点。最后详细论述了超重力技术在Invar合金除杂方面的研究成果和电铸Invar合金箔应用的可行性,并指出超重力技术和电铸技术有望解决近零夹杂金属材料的制备难题。
基金the National Natural Science Foundation of China(U21A20286,22206054 and 21805069)Natural Science Foundation of Hubei(2021CFB094)the Fundamental Research Funds for the Central China Normal University(CCNU)for financial support。
文摘Spinel cobalt oxide(Co_(3)O_(4)),consisting of tetrahedral Co^(2+)(CoTd)and octahedral Co^(3+)(CoOh),is considered as promising earth-abundant electrocatalyst for chlorine evolution reaction(CER).Identifying the catalytic contribution of geometric Co site in the electrocatalytic CER plays a pivotal role to precisely modulate electronic configuration of active Co sites to boost CER.Herein,combining density functional theory calculations and experiment results assisted with operando analysis,we found that the Co_(Oh) site acts as the main active site for CER in spinel Co_(3)O_(4),which shows better Cl^(-)adsorption and more moderate intermediate adsorption toward CER than CoTd site,and does not undergo redox transition under CER condition at applied potentials.Guided by above findings,the oxygen vacancies were further introduced into the Co_(3)O_(4) to precisely manipulate the electronic configuration of Co_(Oh) to boost Cl^(-)adsorption and optimize the reaction path of CER and thus to enhance the intrinsic CER activity significantly.Our work figures out the importance of geometric configuration dependent CER activity,shedding light on the rational design of advanced electrocatalysts from geometric configuration optimization at the atomic level.
文摘目的系统评价护士妊娠期临床工作体验和感受。方法检索PubMed、CINAHL、Embase、Web of Science、Cochrane Library、PsycInfo、CBM、中国知网、万方、维普数据库,筛选有关护士妊娠期临床工作体验的质性研究,检索时限为建库至2023年1月。采用Meta整合方法对结果进行整合分析。结果共纳入12篇文献,提炼出38个研究结果,归纳成6个新类别,综合成3个整合结果:疲倦且交瘁的身心感受;打破原有工作状态及职业规划;多元应对与切身感悟。结论亟需关切妊娠期护士紊乱的身心体验,协助其调适工作状态,系统管理其职业学习及生涯;加强切实的政策管理,巩固妊娠期护士多元支持。
基金This work is supported by“the Fundamental Research Funds for the Central Universities”,111 project No.B20019Shanghai Natural Science Foundation,grant No.19ZR1466800.
文摘The Jiao Tong University Spectroscopic Telescope(JUST)is a 4.4-meter f/6.0 segmented-mirror telescope dedicated to spectroscopic observations.The JUST primary mirror is composed of 18 hexagonal segments,each with a diameter of 1.1 m.JUST provides two Nasmyth platforms for placing science instruments.One Nasmyth focus fits a field of view of 10′and the other has an extended field of view of 1.2°with correction optics.A tertiary mirror is used to switch between the two Nasmyth foci.JUST will be installed at a site at Lenghu in Qinghai Province,China,and will conduct spectroscopic observations with three types of instruments to explore the dark universe,trace the dynamic universe,and search for exoplanets:(1)a multi-fiber(2000 fibers)medium-resolution spectrometer(R=4000-5000)to spectroscopically map galaxies and large-scale structure;(2)an integral field unit(IFU)array of 500 optical fibers and/or a long-slit spectrograph dedicated to fast follow-ups of transient sources for multi-messenger astronomy;(3)a high-resolution spectrometer(R~100000)designed to identify Jupiter analogs and Earth-like planets,with the capability to characterize the atmospheres of hot exoplanets.