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Novel Method for the Enantioselective Synthesis of β-Lactams
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作者 yuan qing jian shan-zhong wang yan-guang 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2008年第1期58-64,共7页
A novel method for the enantioselective synthesis of β-lactams is described in this study. 2,3-Dihydrobenzooxazin-4-one derived from salicylamide and L-menthone was used as the chiral auxiliary, which reacted with a-... A novel method for the enantioselective synthesis of β-lactams is described in this study. 2,3-Dihydrobenzooxazin-4-one derived from salicylamide and L-menthone was used as the chiral auxiliary, which reacted with a-bromo-acyl bromides in the presence of pyridine to give carboximides 2. The stereo-controlled Reformatsky-type reactions of carboximides with imines yielded the corresponding trans β-lactams with high enantioselectivities(e.e. 75%-86%) and high chemical yields(63%-85%), meanwhile, the chiral auxiliary dihydrobenzooxazin-4-one was released and recovered. 展开更多
关键词 Β-LACTAMS ENANTIOSELECTIVE Chiralauxiliary Reformatskyreaction
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