Global Scientific Trends in Research Related to Diabetic Sarcopenia from 1993 to 2023: A Bibliometric Analysis

Objectives: In this study, bibliometric approach was used to explore the literature in the field of research related to Diabetic Myasthenia Gravis in order to identify the current research progress in Diabetic Myasthenia Gravis related research and to help the researchers to predict the future hotspots in the field of research and to provide reference for the research. Methods: Literature related to diabetic sarcopenia published from 1993 to 2023 since the inception of the repository was extracted from the Web of Science Core Collection (WoSCC) and bibliometric analyses were performed. We have analysed the published literature of the last approximately almost 30 years, as well as publication and citation analyses from different countries, institutions, journals and authors. For keywords, we performed co-occurrence, clustering, timeline view and citation burst analysis. Results: On the basis of 1564 publications, we found a continuous increase in the number of publications and citations, especially in the last six years. The United States is the most representative country, and Seoul National University (SNU) is the most representative institution. The most popular journal in the field is Diabetes Care;Fukui, Michiaki is the most prolific author, leading many studies related to diabetic sarcopenia. The most frequently cited reference was a revised European consensus on the definition and diagnosis of sarcopenia;the most cited keywords were related to physiological factors of diabetes, sarcopenia and related conditions, such as “insulin resistance”, “skeletal muscle”, “body composition”, “risk” and “prevalence”. Conclusion: With more and more studies on the relationship between diabetic sarcopenia, this study presents the current status and trend of research related to diabetic sarcopenia over the past nearly 30 years through the visualization software CiteSpace. It can help researchers identify potential collaborators and partner institutions, hotspots and research frontiers in the field of diabetic sarcopenia. However, our work is only based on the English language literature in the WoSCC database, and for future studies, we recommend that researchers explore the literature from multiple databases to enhance the scope of their research.

软土地层临近地铁基坑施工影响控制研究

随着城市地铁沿线地下空间的持续开发,基坑施工对临近地铁变形影响控制越来越受到关注。以上海某邻近地铁的基坑工程为例,通过实测分析和数值计算的方法研究了基坑开挖和拆撑对临近隧道变形的影响,并对伺服系统控制临近隧道变形进行定量分析。结果表明:覆存于软土地层中的隧道对临近施工扰动非常敏感,尽管大区基坑与隧道间距超过2.5倍开挖深度,隧道变形仍超过了监护要求的控制值;大区地下结构施工时拆撑对隧道收敛变形影响超过开挖影响的50%;应力伺服支撑系统对控制临近隧道变形比较有效,适当的“负位移”可以对隧道变形产生有利效果。

基于多目标灰狼优化算法与RBF神经网络的真空灭弧室触头结构优化设计

在真空灭弧室触头开断过程中,合适的磁场分布有利于提高其开断性能;在合闸过程中,动、静触头间存在的电动斥力会导致触头出现弹跳现象。针对以上问题,首先建立了带铁芯式杯状纵磁触头的三维模型,进行了磁场分布与电动力的计算;为了进一步提高触头的性能,然后构建了以触头片开槽长度、开槽宽度、径向偏转角度、杯座斜槽高度及单个斜槽上下旋转角度为输入,电流峰值时刻触头间隙中心平面纵向磁场强度最大值、过零时刻中心点处磁滞时间、合闸时动静触头间的电动斥力分别为输出的RBF神经网络模型;最后结合RBF神经网络模型与多目标灰狼优化算法(MOGWO)对触头结构进行了优化。结果表明:与初始结构参数相比,当触头片开槽长度为19.74mm、宽度为3.94mm、径向偏转角为19.9°、杯座斜槽高度为18.0mm、斜槽上下旋转角为119.2°时,触头具有更好的磁场分布特性,且动、静触头间的电动斥力明显减小,有利于提高触头的工作性能。

带铁心横磁-纵磁触头结构的优化设计

触头作为真空灭弧室的核心元件,其灭弧能力会直接影响直流开断过程。该文通过有限元仿真软件建立了三种触头模型,计算了高频电流下触头产生的磁场分布。电流峰值时的触头间隙中心可产生约为21 mT的纵向磁场,横向磁感应强度约为71 mT,纵向磁场分布不均匀。为了进一步提高触头间隙磁场强度以及分布均匀度,在触头模型中增加铁心及改变铁心结构来提升触头产生的磁场强度,基于BP神经网络与智能优化算法联合的方法对触头模型进行优化设计。优化结果显示:当触头的结构参数外触头非径向开槽夹角α为31.8°、外触头内外半径差值Δ为8.3 mm、内触头片半径r为15.2 mm、外触头杯斜槽高度h为16.1 mm、铁心结构开槽宽度d为1.1 mm时,触头间隙中心产生了74.99 mT的横向磁场;电流峰值时刻的触头间隙中心可产生44.02 mT的纵向磁场,不均匀度从优化前的7.44减小到4.67,均匀度得到了较大提升,提高了磁场对真空电弧的调控能力。

Mesenchymal stromal cells modulate unfolded protein response and preserve β-cell mass in type 1 diabetes

Introduction:Transplantation of mesenchymal stromal cells(MSCs)is a promising therapy for type 1 diabetes(T1D).However,whether the infused MSCs affect the endoplasmic reticulum stress or subsequent unfolded protein response inβcells remains unclear.Methods:To investigate this,we induced early-onset T1D in non-obese diabetic mice using streptozotocin.Subsequently,T1D mice were randomly assigned to receive either MSCs or phosphate-buffered saline.We observed the in vivo homing of MSCs and assessed their effectiveness by analyzing blood glucose levels,body weight,histopathology,pancreatic protein expression,and serum levels of cytokines,proinsulin,and C-peptide.Results:Infused MSCs were found in the lungs,liver,spleen,and pancreas of T1D mice.They exhibited various effects,including reducing blood glucose levels,regulating immunity,inhibiting inflammation,increasingβ-cell areas,and reducing the expression of key proteins in the unfolded protein response pathway.Fasting serum proinsulin and C-peptide levels were significantly higher in the MSCs treatment group than in the T1D model group.However,there was no significant difference in the biomarker ofβ-cell endoplasmic reticulum stress,the ratio of fasting serum proinsulin to C-peptide,between the two groups.Conclusion:Ourfindings reveal that MSCs infusion does not alleviate endoplasmic reticulum stress inβcells directly but modulates the unfolded protein response pathway to preserveβ-cell mass and function in T1D mice.

BEV-radar:毫米波雷达-相机双向融合的三维目标检测

在自动驾驶场景下的3D目标检测任务中,探索毫米波雷达数据作为RGB图像输入的补充正成为多模态融合的新兴趋势。然而,现有的毫米波雷达-相机融合方法高度依赖于相机的一阶段检测结果,导致整体性能不够理想。本文提供了一种不依赖于相机检测结果的鸟瞰图下双向融合方法(BEV-radar)。对于来自不同域的两个模态的特征,BEV-radar设计了一个双向的基于注意力的融合策略。具体地,以基于BEV的3D目标检测方法为基础,我们的方法使用双向转换器嵌入来自两种模态的信息,并根据后续的卷积块强制执行局部空间关系。嵌入特征后,BEV特征在3D对象预测头中解码。我们在nu Scenes数据集上评估了我们的方法,实现了48.2 m AP和57.6 NDS。结果显示,与仅使用相机的基础模型相比,不仅在精度上有所提升,特别地,速度预测误差项有了相当大的改进。代码开源于https://github.com/Etah0409/BEV-Radar。

Coordinated Voltage Control of Distribution Network ConsideringMultiple Types of Electric Vehicles

The couple between the power network and the transportation network(TN)is deepening gradually with the increasing penetration rate of electric vehicles(EV),which also poses a great challenge to the traditional voltage control scheme.In this paper,we propose a coordinated voltage control strategy for the active distribution networks considering multiple types of EV.In the first stage,the action of on-load tap changer and capacitor banks,etc.,are determined by optimal power flow calculation,and the node electricity price is also determined based on dynamic time-of-use tariff mechanism.In the second stage,multiple operating scenarios of multiple types of EVs such as cabs,private cars and buses are considered,and the scheduling results of each EV are solved by building an optimization model based on constraints such as queuing theory,Floyd-Warshall algorithm and traffic flow information.In the third stage,the output power of photovoltaic and energy storage systems is fine-tuned in the normal control mode.The charging power of EVs is also regulated in the emergency control mode to reduce the voltage deviation,and the amount of regulation is calculated based on the fair voltage control mode of EVs.Finally,we test the modified IEEE 33-bus distribution system coupled with the 24-bus Beijing TN.The simulation results show that the proposed scheme can mitigate voltage violations well.

Regulation of TMEM100 expression by epigenetic modification,effects on proliferation and invasion of esophageal squamous carcinoma

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a prevalent malignancy with a high morbidity and mortality rate.TMEM100 has been shown to be suppressor gene in a variety of tumors,but there are no reports on the role of TMEM100 in esophageal cancer(EC).AIM To investigate epigenetic regulation of TMEM100 expression in ESCC and the effect of TMEM100 on ESCC proliferation and invasion.METHODS Firstly,we found the expression of TMEM100 in EC through The Cancer Genome Atlas database.The correlation between TMEM100 gene expression and the survival of patients with EC was further confirmed through Kaplan-Meier analysis.We then added the demethylating agent 5-AZA to ESCC cell lines to explore the regulation of TMEM100 expression by epigenetic modification.To observe the effect of TMEM100 expression on tumor proliferation and invasion by overexpressing TMEM100.Finally,we performed gene set enrichment analysis using the Kyoto Encyclopaedia of Genes and Genomes Orthology-Based Annotation System database to look for pathways that might be affected by TMEM100 and verified the effect of TMEM100 expression on the mitogen-activated protein kinases(MAPK)pathway.RESULTS In the present study,by bioinformatic analysis we found that TMEM100 was lowly expressed in EC patients compared to normal subjects.Kaplan-meier survival analysis showed that low expression of TMEM100 was associated with poor prognosis in patients with EC.Then,we found that the demethylating agent 5-AZA resulted in increased expression of TMEM100 in ESCC cells[quantitative real-time PCR(qRT-PCR)and western blotting].Subsequently,we confirmed that overexpression of TMEM100 leads to its increased expression in ESCC cells(qRT-PCR and western blotting).Overexpression of TMEM100 also inhibited proliferation,invasion and migration of ESCC cells(cell counting kit-8 and clone formation assays).Next,by enrichment analysis,we found that the gene set was significantly enriched in the MAPK signaling pathway.The involvement of TMEM100 in the regulation of MAPK signaling pathway in ESCC cell was subsequently verified by western blotting.CONCLUSION TMEM100 is a suppressor gene in ESCC,and its low expression may lead to aberrant activation of the MAPK pathway.Promoter methylation may play a key role in regulating TMEM100 expression.

Research Progress on Epigenetic Mechanism of Sarcopenia

In recent years, sarcopenia, as a progressive muscular atrophy and weakness, has become one of the common diseases in the elderly. Although its cause is not fully understood, a growing body of research suggests that epigenetic mechanisms play an important role in the pathogenesis of sarcopenia. The purpose of this review is to summarize the current research progress in the epigenetics of sarcopenia, focusing on the role of DNA methylation, RNA methylation and non-coding RNA in the pathogenesis of sarcopenia. While exploring the epigenetic mechanism of sarcopenia, this study will also look into the application prospect of epigenetics in the treatment strategy of sarcopenia, which will provide new ideas and directions for the treatment of sarcopenia.

Cultivation Path of Nursing Undergraduates’Scientific Research and Innovation Ability

Objective: The cultivation of the innovation ability and scientific research is one of the nursing learning objectives for undergraduate students. To explore the method and effect of training system of scientific research innovation ability of nursing undergraduates based on “3332”. Methods: Three course learning modules are constructed: stage-based course learning module, systematic project practice training module and comprehensive practice training module. A practical training platform for scientific research innovation projects is built, and undergraduate scientific research innovation ability training is carried out from both in-class and out-of-class lines. Results: Since 2017, the students have obtained 7 national innovation and entrepreneurship training programs, 52 university-level undergraduate scientific research projects, published more than 10 academic papers, and obtained 2 patent authorization. Conclusions: The training system of scientific research innovation ability of nursing undergraduates based on “3332” is conducive to the development of scientific research innovation ability of nursing students, and to cultivate nursing talents who can adapt to the development of the new era and have better post competence.

Cultivation Path of Nursing Undergraduates’ Scientific Research and Innovation Ability

Objective:The cultivation of the innovation ability and scientific research is one of the nursing learning objectives for undergraduate students.To explore the method and effect of training system of scientific research innovation ability of nursing undergraduates based on“3332”.Methods:Three course learning modules are constructed:stage-based course learning module,systematic project practice training module and comprehensive practice training module.A practical training platform for scientific research innovation projects is built,and undergraduate scientific research innovation ability training is carried out from both in-class and out-of-class lines.Results:Since 2017,the students have obtained 7 national innovation and entrepreneurship training programs,52 university-level undergraduate scientific research projects,published more than 10 academic papers,and obtained 2 patent authorization.Conclusions:The training system of scientific research innovation ability of nursing undergraduates based on“3332”is conducive to the development of scientific research innovation ability of nursing students,and to cultivate nursing talents who can adapt to the development of the new era and have better post competence.

真空拉弧起始收缩过程实验研究

真空电弧的形态分布主导燃弧阶段等离子体分布特性,起始收缩过程的等离子体分布对成功开断有重要影响。为了研究机构运动过程中真空电弧的起始收缩特性,分析燃弧工况对收缩持续时间的影响,文中以10 kV可拆真空灭弧室为载体,建立真空电弧工频开断实验平台及电弧形态观测系统,通过改变灭弧室参数,结合电弧图像数字处理技术,对真空拉弧起始收缩时间进行定量分析。结果表明:起始收缩电弧的持续时间基本与电流幅值和起弧电流呈较明显正相关,与机构分闸速度呈负相关。纵向磁场对中心弧柱和边缘区域作用相反,文中利于扩散的临界磁场为60 mT,当纵向磁场小于60 mT时,收缩态电弧趋向扩散;纵向磁场大于60 mT时,收缩态持续时间增大。

一种带自充电支路的改进型混合直流断路器

直流断路器作为柔性直流电网的关键设备,对直流输配电网的安全、稳定运行有着重要的意义。针对带限流能力的直流断路器存在的造价偏高、故障清除速度慢等问题,提出了一种带自充电支路的改进型混合直流断路器(improved hybrid DC circuit breaker with self-charging branch,SCB-IHDCCB)拓扑,设置限流电感旁路和接地旁路,优化自充电支路路线,将泄能支路与自充电支路结合使用,在保证断路器性能的前提下,减少了支路数量,大大降低了晶闸管等元器件数量,从而大大降低其造价。对所提拓扑在单端系统中的工况进行了理论推导与分析,基于所提拓扑设计了500kV的单端直流系统,在PSCAD/EMTDC中建立模型进行了仿真验证,并与其他拓扑方案的性能、元器件数量进行比较。仿真结果表明,SCB-IHDCCB的性能和造价都得到较大优化,具有良好的经济性和应用前景。

Hyponatremic encephalopathy due to polyethylene glycol-based bowel preparation for colonoscopy:A case report

BACKGROUND Adequate bowel preparation is critical for colonoscopy screening.At present,the most widely used intestinal cleaner recommended at home and abroad is Polyethylene glycol(PEG).Intestinal cleansers can cause electrolyte disturbances and hyponatremia.However,hyponatremic encephalopathy due to hyponatremia induced by PEG solution,although rare,can lead to serious irreversible sequelae and even death.CASE SUMMARY In this report,we discuss a case of neurological dysfunction due to hyponatremia,also known as hyponatremic encephalopathy,observed in a 63-year-old woman who underwent PEG-based bowel preparation for colonoscopy.She was eventually transferred to our intensive care unit for treatment due to her Glasgow Coma Scale score of 9/15(Eye opening 2;Verbal response 1;Motor response 6)and abnormal laboratory tests.CONCLUSION Physicians should be thoroughly familiarized with the patient’s history before prescribing PEG for bowel preparation,and timely identification of patients with hyponatremic encephalopathy is essential as delayed treatment is associated with poor neurological outcomes.An intravenous infusion of 3%sodium chloride is recommended at the onset of early symptoms.The goal of treatment is to adequately treat cerebral edema while avoiding serum sodium correction beyond 15 to 20 m Eq/L within 48 h of treatment to prevent osmotic demyelination syndrome.

Overcritical electron acceleration and betatron radiation in the bubble-like structure formed by re-injected electrons in a tailored transverse plasma

We present a novel scheme for dense electron acceleration driven by the laser irradiation of a near-critical-density plasma.The electron reflux effect in a transversely tailored plasma is particularly enhanced in the area of peak density.We observe a bubble-like distribution of re-injected electrons,which forms a strong quasistatic electromagnetic field that can accelerate electrons longitudinally while also preserving the electron transverse emittance.Simulation results demonstrate that over-dense electrons could be trapped in such an artificial bubble and accelerated to an energy of ~500 MeV.The obtained relativistic electron beam can reach a total charge of up to 0.26 nC and is well collimated with a small divergence of 17 mrad.Moreover,the wavelength of electron oscillation is noticeably reduced due to the shaking of the bubble structure in the laser field.As a result,the energy of the produced photons is substantially increased to the range.This new regime provides a path to generating high-charge electron beams and high-energy-ray sources.

Nonlinear optical microscopy for skin in vivo:Basics,development and applications

Multi-photon microscopy(MPM)and coherent anti-Stokes Raman scattering(CARS)are two advanced nonlinear optical imaging techniques,which provide complementary information and have great potential in combination for noninvasive in vrito biomedical applications.This paper provides a detailed discussion of the basics,development and applications of these technologies for in vrivo skin research,covering the following topics:The principle and advantage of MPM and CARS,instrumentation development for in vino applications,MPM and CARS of normal skin,application of MPM and CARS in skin cancer and disease diagnosis;application of MPM in skin disease intervention,ie.,imaging guided two-photon photothermolysis.

Multimodel ensemble projection of photovoltaic power potential in China by the 2060s

为了实现能源转型的目标,中国对太阳能的需求一直在极速增长.然而,太阳能发电潜力受到天气条件的影响并预期在气候变暖背景下发生改变.本文中,作者利用第六次国际耦合模式比较计划(CMIP6)24个气候模式的气象变量以及4个不同形式的光伏模型,预估了在2060年代低排放或高排放情况下中国的光伏发电潜力.多模式集合平均光伏功率在2004-2014年为277.2KWhm-2yr-1,并呈现出从西到东的下降趋势.到2054-2064年,在低排放情景下,全国平均光伏发电潜力将增加2.29%,而在高排放情景下则减少0.43%.低排放情景的排放控制大大增强了地表太阳辐射,促进了东部的光伏发电.相反,在高排放情景下,强烈的变暖对光伏发电产生了抑制作用.极端暖事件使光伏发电潜力在低排放情景下降低0.28%,而高排放情景下降低0.44%,分别相当于当代损失量的两倍和三倍.预估表明排放控制带来的清洁空气和适度变暖对中国未来的太阳能利用是有益的.

Single-cell transcriptome analysis uncovers underlying mechanisms of acute liver injury induced by tripterygium glycosides tablet in mice

Tripterygium glycosides tablet(TGT),the classical commercial drug of Tripterygium wilfordii Hook.F.has been effectively used in the treatment of rheumatoid arthritis,nephrotic syndrome,leprosy,Behcet's syndrome,leprosy reaction and autoimmune hepatitis.However,due to its narrow and limited treatment window,TGT-induced organ toxicity(among which liver injury accounts for about 40%of clinical reports)has gained increasing attention.The present study aimed to clarify the cellular and molecular events underlying TGT-induced acute liver injury using single-cell RNA sequencing(scRNA-seq)technology.The TGT-induced acute liver injury mouse model was constructed through short-term TGT exposure and further verified by hematoxylin-eosin staining and liver function-related serum indicators,including alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase and total bilirubin.Using the mouse model,we identified 15 specific subtypes of cells in the liver tissue,including endothelial cells,hepatocytes,cholangiocytes,and hepatic stellate cells.Further analysis indicated that TGT caused a significant inflammatory response in liver endothelial cells at different spatial locations;led to marked inflammatory response,apoptosis and fatty acid metabolism dysfunction in hepatocytes;activated hepatic stellate cells;brought about the activation,inflammation,and phagocytosis of liver capsular macrophages cells;resulted in immune dysfunction of liver lymphocytes;disturbed the intercellular crosstalk in liver microenvironment by regulating various signaling pathways.Thus,these findings elaborate the mechanism underlying TGT-induced acute liver injury,provide new insights into the safe and rational applications in the clinic,and complement the identification of new biomarkers and therapeutic targets for liver protection.

Two-Dimensional Gap Solitons in Parity-Time Symmetry Moiré Optical Lattices with Rydberg–Rydberg Interaction

Realizing single light solitons that are stable in high dimensions is a long-standing goal in research of nonlinear optical physics.Here,we address a scheme to generate stable two-dimensional solitons in a cold Rydberg atomic system with a parity-time(PT) symmetric moiré optical lattice.We uncover the formation,properties,and their dynamics of fundamental and two-pole gap solitons as well as vortical ones.The PT symmetry,lattice strength,and the degrees of local and nonlocal nonlinearity are tunable and can be used to control solitons.The stability regions of these solitons are evaluated in two numerical ways:linear-stability analysis and time evolutions with perturbations.Our results provide an insightful understanding of solitons physics in combined versatile platforms of PT-symmetric systems and Rydberg–Rydberg interaction in cold gases.

电磁斥力机构研究综述

直流电网的发展和直流断路器的应用需求对机械开关及其操动机构提出了新的快速性、可靠性和经济性的要求。为此介绍了新型电磁斥力机构的基本原理,综述了电磁斥力机构的结构形式,总结了国内外对驱动特性开展的数值分析和解析分析工作,研究表明:数值分析能给出经验性优化规律,难以准确描述优化设计方法,解析分析是驱动特性研究的有效方法。电磁斥力机械开关研制工作的关键问题是:驱动效率的提高;适配缓冲和保持技术;传动系统冲击应力分析和结构强度设计方法;长行程应用可行性研究。