After intraocular implantation of F ion-heparin surface modified intraocular lenses(FHSM IOLs) in the rabbits’eyes,there were small cells on the surfaces of IOLs accompanied by fibrinous exudates in the early days.Th...After intraocular implantation of F ion-heparin surface modified intraocular lenses(FHSM IOLs) in the rabbits’eyes,there were small cells on the surfaces of IOLs accompanied by fibrinous exudates in the early days.The cells included macrophages,fibroblast like cells,epithelioid cells,small foreign body giant cells and lymphocytes.As time went on it showed increasing variation of cell size and fusion of cells.At last the surface of IOLs were covered by a thin and transparent membrane chiefly made by degenerated cells and fibrins,and then the IOLs were well tolerated in the eyes.展开更多
Objective: To study the levels of sIL 2R and TNF α in the aqueous of Rhesus Monkeys eyes and the biocompatibility implanted with F heparin modified intraocular lens(IOLs).Methods: Twelve monkeys were classified int...Objective: To study the levels of sIL 2R and TNF α in the aqueous of Rhesus Monkeys eyes and the biocompatibility implanted with F heparin modified intraocular lens(IOLs).Methods: Twelve monkeys were classified into 3 groups which were normal,control and experimental groups.PMMA IOLs and modified PMMA IOLs were implanted into monkeyseyes.Aqueous from anterior chamber was aspirated at 15,30,60,90,180 and 360 days.The level of sIL 2R was measured by ELISA and TNF α by radioimmunoassay.Results: The level of sIL 2R in aqueous increased at 15 day,reached the highest level at 30 day and returned to normal at 90 day.At 15,30 days the level of sIL 2R in aqueous in control group was higher than that in experimental group.The content of TNF α in aqueous was the highest at 15 day and returned at 60 day.At 15 day the content of TNF α in control group was higher and decreased slower than that in experimental group.Conclusion: F heparin modified IOLs with better biocompatibility induced lower foreign body reaction and inflammatory reaction than that of polymethylmethacrylate (PMMA) IOLs.展开更多
文摘After intraocular implantation of F ion-heparin surface modified intraocular lenses(FHSM IOLs) in the rabbits’eyes,there were small cells on the surfaces of IOLs accompanied by fibrinous exudates in the early days.The cells included macrophages,fibroblast like cells,epithelioid cells,small foreign body giant cells and lymphocytes.As time went on it showed increasing variation of cell size and fusion of cells.At last the surface of IOLs were covered by a thin and transparent membrane chiefly made by degenerated cells and fibrins,and then the IOLs were well tolerated in the eyes.
文摘Objective: To study the levels of sIL 2R and TNF α in the aqueous of Rhesus Monkeys eyes and the biocompatibility implanted with F heparin modified intraocular lens(IOLs).Methods: Twelve monkeys were classified into 3 groups which were normal,control and experimental groups.PMMA IOLs and modified PMMA IOLs were implanted into monkeyseyes.Aqueous from anterior chamber was aspirated at 15,30,60,90,180 and 360 days.The level of sIL 2R was measured by ELISA and TNF α by radioimmunoassay.Results: The level of sIL 2R in aqueous increased at 15 day,reached the highest level at 30 day and returned to normal at 90 day.At 15,30 days the level of sIL 2R in aqueous in control group was higher than that in experimental group.The content of TNF α in aqueous was the highest at 15 day and returned at 60 day.At 15 day the content of TNF α in control group was higher and decreased slower than that in experimental group.Conclusion: F heparin modified IOLs with better biocompatibility induced lower foreign body reaction and inflammatory reaction than that of polymethylmethacrylate (PMMA) IOLs.
