目的:观察氧嗪酸钾模型大鼠饮用洋槐蜂蜜(AH)水溶液后,对大鼠血尿酸水平及肾功能的影响。方法:雄性SD大鼠60只,随机分为空白对照组(CON组)、氧嗪酸钾模型组(OA模型组)、10%果糖组(10%F组)以及不同浓度蜂蜜组(25%、12.5%及6.25%AH组)。...目的:观察氧嗪酸钾模型大鼠饮用洋槐蜂蜜(AH)水溶液后,对大鼠血尿酸水平及肾功能的影响。方法:雄性SD大鼠60只,随机分为空白对照组(CON组)、氧嗪酸钾模型组(OA模型组)、10%果糖组(10%F组)以及不同浓度蜂蜜组(25%、12.5%及6.25%AH组)。所有大鼠正常饲料喂养,CON对照组每日皮下注射5%羧甲基纤维素钠(CMC-Na)溶液同时饮用无菌水,其余各组大鼠每日皮下注射100 mg/kg OA CMC-Na混悬溶液,同时饮用无菌水、果糖或不同浓度AH水溶液。本实验为期4周。实验前及实验期间大鼠每周称重并取血一次,实验结束后取血、尿、粪便及肾脏组织,测定血、尿、粪便中尿酸含量、血清肌酐(Cre)及尿素氮(BUN)水平及肾脏组织炎症因子,并进行肾脏组织病理切片观察。结果:与空白对照组相比,蜂蜜可显著降低大鼠体质量(P<0.05),增加大鼠肾脏脏器系数,升高大鼠血尿酸、尿尿酸(UUA)、血清肌酐及尿素氮水平,降低大鼠粪尿酸(FUA)水平;蜂蜜可下调大鼠肾脏组织肿瘤坏死因子-α(TNF-α)水平(P<0.05)、上调单核细胞趋化蛋白1(MCP-1)及转化生长因子β1(TGF-β1)表达水平;蜂蜜能引起大鼠肾脏组织肾小管轻微到轻度扩张及轻到中度嗜碱性病变,并具有剂量依赖性。结论:在研究剂量范围内,蜂蜜能引起大鼠高尿酸血症、肾小管扩张及嗜碱性病变,导致肾功能损伤。展开更多
One summer some years ago, two friends of mine, who were notedcameramen, and I ventured into Ngari. We left Beijing and went from Lhasa, Gyangze, Tingri, Burang, Zada and eventually reached Shiquanhe, capital of Ngari...One summer some years ago, two friends of mine, who were notedcameramen, and I ventured into Ngari. We left Beijing and went from Lhasa, Gyangze, Tingri, Burang, Zada and eventually reached Shiquanhe, capital of Ngari Prefecture. Our trip lasted for some 40 days, covering a distance of 14,390 km. We encountered many new things sights. However, what was most interesting was what is known today as the Clay Forests in Zada.Clay Forest and Zada County SeatIt was a mid-August day, the ninth on our trip to Ngari. We set out from展开更多
文摘目的:观察氧嗪酸钾模型大鼠饮用洋槐蜂蜜(AH)水溶液后,对大鼠血尿酸水平及肾功能的影响。方法:雄性SD大鼠60只,随机分为空白对照组(CON组)、氧嗪酸钾模型组(OA模型组)、10%果糖组(10%F组)以及不同浓度蜂蜜组(25%、12.5%及6.25%AH组)。所有大鼠正常饲料喂养,CON对照组每日皮下注射5%羧甲基纤维素钠(CMC-Na)溶液同时饮用无菌水,其余各组大鼠每日皮下注射100 mg/kg OA CMC-Na混悬溶液,同时饮用无菌水、果糖或不同浓度AH水溶液。本实验为期4周。实验前及实验期间大鼠每周称重并取血一次,实验结束后取血、尿、粪便及肾脏组织,测定血、尿、粪便中尿酸含量、血清肌酐(Cre)及尿素氮(BUN)水平及肾脏组织炎症因子,并进行肾脏组织病理切片观察。结果:与空白对照组相比,蜂蜜可显著降低大鼠体质量(P<0.05),增加大鼠肾脏脏器系数,升高大鼠血尿酸、尿尿酸(UUA)、血清肌酐及尿素氮水平,降低大鼠粪尿酸(FUA)水平;蜂蜜可下调大鼠肾脏组织肿瘤坏死因子-α(TNF-α)水平(P<0.05)、上调单核细胞趋化蛋白1(MCP-1)及转化生长因子β1(TGF-β1)表达水平;蜂蜜能引起大鼠肾脏组织肾小管轻微到轻度扩张及轻到中度嗜碱性病变,并具有剂量依赖性。结论:在研究剂量范围内,蜂蜜能引起大鼠高尿酸血症、肾小管扩张及嗜碱性病变,导致肾功能损伤。
文摘One summer some years ago, two friends of mine, who were notedcameramen, and I ventured into Ngari. We left Beijing and went from Lhasa, Gyangze, Tingri, Burang, Zada and eventually reached Shiquanhe, capital of Ngari Prefecture. Our trip lasted for some 40 days, covering a distance of 14,390 km. We encountered many new things sights. However, what was most interesting was what is known today as the Clay Forests in Zada.Clay Forest and Zada County SeatIt was a mid-August day, the ninth on our trip to Ngari. We set out from
