In this paper,we present a novel and robust nonlinear precoding(NLP)design and detection structure specifically tailored for multiple-input multipleoutput space division multiple access(MIMO-SDMA)systems toward 6G wir...In this paper,we present a novel and robust nonlinear precoding(NLP)design and detection structure specifically tailored for multiple-input multipleoutput space division multiple access(MIMO-SDMA)systems toward 6G wireless.Our approach aims to effectively mitigate the impact of imperfect channel estimation by leveraging the channel fluctuation mean square error(MSE)for reconstructing a highly accurate precoding matrix at the transmitter.Furthermore,we introduce a simplified receiver structure that eliminates the need for equalization,resulting in reduced interference and notable enhancements in overall system performance.We conduct both computer simulations and experimental tests to validate the efficacy of our proposed approach.The results reveals that the proposed NLP scheme offers significant performance improvements,making it particularly well-suited for the forthcoming 6G wireless.展开更多
目的 对护士肠内营养相关性腹泻定义、态度和行为问卷(definitions, attitudes and practices in relation to diarrhea during enteral nutrition questionnaire, DAPonDEN)进行汉化和信效度检验。方法 对源问卷进行翻译、回译、预调...目的 对护士肠内营养相关性腹泻定义、态度和行为问卷(definitions, attitudes and practices in relation to diarrhea during enteral nutrition questionnaire, DAPonDEN)进行汉化和信效度检验。方法 对源问卷进行翻译、回译、预调查及跨文化调适,形成中文版DAPonDEN。应用其对478名护士进行问卷调查,并检验其信效度。结果 中文版DAPonDEN包括3个维度共24个条目,定义、态度和行为维度累计方差贡献率分别为68.76%、72.77%和62.24%,项目分析各条目与总分的相关系数为0.367~0.642,决断值为6.569~16.988,差异均有统计学意义(P<0.01)。总问卷的Cronbach’s α系数为0.873,条目水平内容效度为0.71~1.00,问卷平均内容效度为0.98,重测信度为0.745。结论 中文版DAPonDEN信效度良好,可用于评估和比较护士在患者肠内营养相关性腹泻方面的定义、态度和行为水平。展开更多
In this paper,a powerful model-driven deep learning framework is exploited to overcome the challenge of multi-domain signal detection in spacedomain index modulation(SDIM)based multiple input multiple output(MIMO)syst...In this paper,a powerful model-driven deep learning framework is exploited to overcome the challenge of multi-domain signal detection in spacedomain index modulation(SDIM)based multiple input multiple output(MIMO)systems.Specifically,we use orthogonal approximate message passing(OAMP)technique to develop OAMPNet,which is a novel signal recovery mechanism in the field of compressed sensing that effectively uses the sparse property from the training SDIM samples.For OAMPNet,the prior probability of the transmit signal has a significant impact on the obtainable performance.For this reason,in our design,we first derive the prior probability of transmitting signals on each antenna for SDIMMIMO systems,which is different from the conventional massive MIMO systems.Then,for massive MIMO scenarios,we propose two novel algorithms to avoid pre-storing all active antenna combinations,thus considerably improving the memory efficiency and reducing the related overhead.Our simulation results show that the proposed framework outperforms the conventional optimization-driven based detection algorithms and has strong robustness under different antenna scales.展开更多
Anti-cancer therapy often causes premature ovarian insufficiency and infertility as the ovarian follicle reserve is extremely sensitive to chemotherapy drugs,such as cisplatin.Various fertility preservation methods ha...Anti-cancer therapy often causes premature ovarian insufficiency and infertility as the ovarian follicle reserve is extremely sensitive to chemotherapy drugs,such as cisplatin.Various fertility preservation methods have been explored for women,especially prepubertal girls undergoing radiotherapy and chemotherapy due to cancer.In recent years,mesenchymal stem cell-derived exosomes(MSC-exos)have been reported to play an important role in tissue repair and the treatment of various diseases.In the current study,we observed that human umbilical cord-derived MSC-exos(hucMSC-exos)after short-term culture improved follicular survival and development while receiving cisplatin treatment.Moreover,intravenous injection of hucMSC-exos improved ovarian function and ameliorated inflammatory environment within the ovary.The underlying mechanism of hucMSC-exos on fertility preservation was associated with the down-regulation of p53-related apoptosis and their anti-inflammatory function.Based on these findings,we propose that hucMSC-exos may be a potential approach to improve fertility in women diagnosed with cancer.展开更多
Objective This study aims to estimate the cost-effectiveness of the combined chemotherapy regimen containing Bedaquiline(BR)and the conventional treatment regimen(CR,not containing Bedaquiline)for the treatment of adu...Objective This study aims to estimate the cost-effectiveness of the combined chemotherapy regimen containing Bedaquiline(BR)and the conventional treatment regimen(CR,not containing Bedaquiline)for the treatment of adults with multidrug-resistant tuberculosis(MDR-TB)in China.Methods A combination of a decision tree and a Markov model was developed to estimate the cost and effects of MDR patients in BR and CR within ten years.The model parameter data were synthesized from the literature,the national TB surveillance information system,and consultation with experts.The incremental cost-effectiveness ratio(ICER)of BR vs.CR was determined.Results BR(vs.CR)had a higher sputum culture conversion rate and cure rate and prevented many premature deaths(decreased by 12.8%),thereby obtaining more quality-adjusted life years(QALYs)(increased by 2.31 years).The per capita cost in BR was as high as 138,000 yuan,roughly double that of CR.The ICER for BR was 33,700 yuan/QALY,which was lower than China's 1×per capita Gross Domestic Product(GDP)in 2020(72,400 yuan).Conclusion BR is shown to be cost effective.When the unit price of Bedaquiline reaches or falls below57.21 yuan per unit,BR is expected to be the dominant strategy in China over CR.展开更多
In this letter,the effect of slip boundary on the origin of subcritical transition in two-dimensional chan-nel flows is studied numerically and theoretically.It is shown that both the positive and the negative slip le...In this letter,the effect of slip boundary on the origin of subcritical transition in two-dimensional chan-nel flows is studied numerically and theoretically.It is shown that both the positive and the negative slip lengths will increase the critical Reynolds number of localized wave packet and hence postpone the transition.By applying a variable transformation and expanding the variables about a small slip length,it is illustrated that the slip boundary effect only exists in the second and higher order modulations of the no-slip solution,and hence explains the power law found in simulations,i.e.the relative increment of the critical Reynolds number due to the slip boundary is proportional to the square of the slip length.展开更多
Glioma is the most common primary brain tumor.Exploration of new tumorigenesis mechanism of glioma is critical to determine more effective treatment targets as well as to develop effective prognosis methods that can e...Glioma is the most common primary brain tumor.Exploration of new tumorigenesis mechanism of glioma is critical to determine more effective treatment targets as well as to develop effective prognosis methods that can enhance the treatment efficacy.We previously demonstrated that the deubiquitinase biquitin carboxyl-terminal hydrolase L5(UCHL5)was downregulated in human glioma.However,the effect and mechanism of UCHL5 on the proliferation of glioma cells remains unknown.Methods:Transfection of siRNA was used to knockdown the expression of UCHL5 in U251 cells.The 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide(MTT)assay,Edu assay,and colony formation assay were employed to identify the effect of UCHL5 on the proliferation of U251 glioma cells.Western blotting and quantitative real-time PCR were carried out to detect the interaction of UCHL5 and PTEN.The effect of UCHL5 on the growth of glioma in vivo was evaluated in nude mice.Then Immunohistochemistry(IHC)were performed to analysis the expression of UCHL5 and PTEN in human glioma tissues.Results:Here,we have reported that silencing of UCHL5 could promote the proliferation of U251 glioma cells through MTT assay,Edu assay,and colony formation assay.Mechanically,we revealed that UCHL5 stabilizes the phosphatase and tensin homolog(PTEN)expression by deubiquitination,thereby inhibiting cell proliferation in U251 cells.Tumor xenograft experiments further demonstrated that silencing the UCHL5 expression could accelerate U251 cell growth in vivo.Finally,in human glioma tissue microarray,the positive correlation between UCHL5 and PTEN expression was confirmed through IHC assay.Conclusion:UCHL5 restrains the proliferation of U251 glioma cells by stabilizing and deubiquitinating PTEN.Our findings provide ideas for developing enhanced targeted PTEN therapy for patients with glioma.展开更多
基金supported in part by National Key R&D Program of China(2020YFB1807203)National Science Foundation of China under Grant number 62071111+2 种基金the Fundamental Research Funds for the Central Universities under Grant 2242022k60006Natural Science Foundation of Sichuan Province under Grant number 2022NSFSC0487the National Key Laboratory of Wireless Communications Foundation under Grant IFN20230104。
文摘In this paper,we present a novel and robust nonlinear precoding(NLP)design and detection structure specifically tailored for multiple-input multipleoutput space division multiple access(MIMO-SDMA)systems toward 6G wireless.Our approach aims to effectively mitigate the impact of imperfect channel estimation by leveraging the channel fluctuation mean square error(MSE)for reconstructing a highly accurate precoding matrix at the transmitter.Furthermore,we introduce a simplified receiver structure that eliminates the need for equalization,resulting in reduced interference and notable enhancements in overall system performance.We conduct both computer simulations and experimental tests to validate the efficacy of our proposed approach.The results reveals that the proposed NLP scheme offers significant performance improvements,making it particularly well-suited for the forthcoming 6G wireless.
文摘目的 对护士肠内营养相关性腹泻定义、态度和行为问卷(definitions, attitudes and practices in relation to diarrhea during enteral nutrition questionnaire, DAPonDEN)进行汉化和信效度检验。方法 对源问卷进行翻译、回译、预调查及跨文化调适,形成中文版DAPonDEN。应用其对478名护士进行问卷调查,并检验其信效度。结果 中文版DAPonDEN包括3个维度共24个条目,定义、态度和行为维度累计方差贡献率分别为68.76%、72.77%和62.24%,项目分析各条目与总分的相关系数为0.367~0.642,决断值为6.569~16.988,差异均有统计学意义(P<0.01)。总问卷的Cronbach’s α系数为0.873,条目水平内容效度为0.71~1.00,问卷平均内容效度为0.98,重测信度为0.745。结论 中文版DAPonDEN信效度良好,可用于评估和比较护士在患者肠内营养相关性腹泻方面的定义、态度和行为水平。
基金supported by the National Natural Science Foundation of China(No.22103023,No.22173040,No.22241301,No.22103032,No.22173042,and No.21973037)the Shenzhen Science and Technology Innovation Committee(No.ZDSYS20200421111001787,No.JCYJ20210324103810029,No.20220815145746004,and No.2021344670)+1 种基金the Guangdong Innovative&Entrepreneurial Research Team Program(No.2019ZT08L455 and No.2019JC01X091)Innovation Program for Quantum Science and Technology(No.2021ZD0303304).
基金supported by the National Natural Science Foundation of China under Grant U19B2014the Sichuan Science and Technology Program under Grant 2023NSFSC0457the Fundamental Research Funds for the Central Universities under Grant 2242022k60006.
文摘In this paper,a powerful model-driven deep learning framework is exploited to overcome the challenge of multi-domain signal detection in spacedomain index modulation(SDIM)based multiple input multiple output(MIMO)systems.Specifically,we use orthogonal approximate message passing(OAMP)technique to develop OAMPNet,which is a novel signal recovery mechanism in the field of compressed sensing that effectively uses the sparse property from the training SDIM samples.For OAMPNet,the prior probability of the transmit signal has a significant impact on the obtainable performance.For this reason,in our design,we first derive the prior probability of transmitting signals on each antenna for SDIMMIMO systems,which is different from the conventional massive MIMO systems.Then,for massive MIMO scenarios,we propose two novel algorithms to avoid pre-storing all active antenna combinations,thus considerably improving the memory efficiency and reducing the related overhead.Our simulation results show that the proposed framework outperforms the conventional optimization-driven based detection algorithms and has strong robustness under different antenna scales.
基金supported by the National Key Research and Development Program of China(Grant Nos.2018YFC1003703 and 2018YFC1004203)the National Natural Science Foundation of China(Grant No.31871513).
文摘Anti-cancer therapy often causes premature ovarian insufficiency and infertility as the ovarian follicle reserve is extremely sensitive to chemotherapy drugs,such as cisplatin.Various fertility preservation methods have been explored for women,especially prepubertal girls undergoing radiotherapy and chemotherapy due to cancer.In recent years,mesenchymal stem cell-derived exosomes(MSC-exos)have been reported to play an important role in tissue repair and the treatment of various diseases.In the current study,we observed that human umbilical cord-derived MSC-exos(hucMSC-exos)after short-term culture improved follicular survival and development while receiving cisplatin treatment.Moreover,intravenous injection of hucMSC-exos improved ovarian function and ameliorated inflammatory environment within the ovary.The underlying mechanism of hucMSC-exos on fertility preservation was associated with the down-regulation of p53-related apoptosis and their anti-inflammatory function.Based on these findings,we propose that hucMSC-exos may be a potential approach to improve fertility in women diagnosed with cancer.
基金supported by The National 13th Five-year Mega-Scientific Projects of Infectious Diseases in China[Grant Number:2017ZX10201302001004]。
文摘Objective This study aims to estimate the cost-effectiveness of the combined chemotherapy regimen containing Bedaquiline(BR)and the conventional treatment regimen(CR,not containing Bedaquiline)for the treatment of adults with multidrug-resistant tuberculosis(MDR-TB)in China.Methods A combination of a decision tree and a Markov model was developed to estimate the cost and effects of MDR patients in BR and CR within ten years.The model parameter data were synthesized from the literature,the national TB surveillance information system,and consultation with experts.The incremental cost-effectiveness ratio(ICER)of BR vs.CR was determined.Results BR(vs.CR)had a higher sputum culture conversion rate and cure rate and prevented many premature deaths(decreased by 12.8%),thereby obtaining more quality-adjusted life years(QALYs)(increased by 2.31 years).The per capita cost in BR was as high as 138,000 yuan,roughly double that of CR.The ICER for BR was 33,700 yuan/QALY,which was lower than China's 1×per capita Gross Domestic Product(GDP)in 2020(72,400 yuan).Conclusion BR is shown to be cost effective.When the unit price of Bedaquiline reaches or falls below57.21 yuan per unit,BR is expected to be the dominant strategy in China over CR.
基金The present research is financially supported by the National Natural Science Foundation of China(Grants No.91752203).
文摘In this letter,the effect of slip boundary on the origin of subcritical transition in two-dimensional chan-nel flows is studied numerically and theoretically.It is shown that both the positive and the negative slip lengths will increase the critical Reynolds number of localized wave packet and hence postpone the transition.By applying a variable transformation and expanding the variables about a small slip length,it is illustrated that the slip boundary effect only exists in the second and higher order modulations of the no-slip solution,and hence explains the power law found in simulations,i.e.the relative increment of the critical Reynolds number due to the slip boundary is proportional to the square of the slip length.
基金supported by grants from the Shenzhen Science and Technology Innovation Commission Grant(Nos.JCYJ20180507182253653 and JCYJ20190808172201639)Guangdong Province Basic and Applied Basic Research Fund(No.2022A1515111143).
文摘Glioma is the most common primary brain tumor.Exploration of new tumorigenesis mechanism of glioma is critical to determine more effective treatment targets as well as to develop effective prognosis methods that can enhance the treatment efficacy.We previously demonstrated that the deubiquitinase biquitin carboxyl-terminal hydrolase L5(UCHL5)was downregulated in human glioma.However,the effect and mechanism of UCHL5 on the proliferation of glioma cells remains unknown.Methods:Transfection of siRNA was used to knockdown the expression of UCHL5 in U251 cells.The 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide(MTT)assay,Edu assay,and colony formation assay were employed to identify the effect of UCHL5 on the proliferation of U251 glioma cells.Western blotting and quantitative real-time PCR were carried out to detect the interaction of UCHL5 and PTEN.The effect of UCHL5 on the growth of glioma in vivo was evaluated in nude mice.Then Immunohistochemistry(IHC)were performed to analysis the expression of UCHL5 and PTEN in human glioma tissues.Results:Here,we have reported that silencing of UCHL5 could promote the proliferation of U251 glioma cells through MTT assay,Edu assay,and colony formation assay.Mechanically,we revealed that UCHL5 stabilizes the phosphatase and tensin homolog(PTEN)expression by deubiquitination,thereby inhibiting cell proliferation in U251 cells.Tumor xenograft experiments further demonstrated that silencing the UCHL5 expression could accelerate U251 cell growth in vivo.Finally,in human glioma tissue microarray,the positive correlation between UCHL5 and PTEN expression was confirmed through IHC assay.Conclusion:UCHL5 restrains the proliferation of U251 glioma cells by stabilizing and deubiquitinating PTEN.Our findings provide ideas for developing enhanced targeted PTEN therapy for patients with glioma.
