As a natural analog of resveratrol,piceatannol(Pic)exhibits good antioxidant and anti-inflammatory activities in different disease models.However,the role of Pic in type 1 diabetes mousemodel has not been reported yet...As a natural analog of resveratrol,piceatannol(Pic)exhibits good antioxidant and anti-inflammatory activities in different disease models.However,the role of Pic in type 1 diabetes mousemodel has not been reported yet.In this study,we investigated the in vivo effect of Pic in streptozotocin(STZ)-induced type 1 diabetic mice.Mice were injected with STZ to establish the type 1 diabetesmellitus(T1DM)model.After stable hyperglycemia was achieved,mice were then orally treated with Pic(40 mg/kg b.w.,i.g.)for 30 days.The results indicated that Pic supplementation efficiently alleviated the typical symptoms associated with T1DM,including body weight loss,polydipsia,hyperglycemia,and hypoinsulinemia.Pic treatment also improved the glucose tolerance of STZ-induced diabetic mice.In addition,Pic supplementation markedly decreased the expression of pro-inflammatory molecules TNF-αand IL-6,the expression of endoplasmic reticulum(ER)stress markers GRP78 and CHOP,and the level of oxidative stress in T1DM mice.Moreover,Pic administration also partly reversed the metabolic profiles of STZ-treated mice as detected by 1H Nuclear Magnetic Resonance(NMR)-based metabolomics.Our study suggested that the therapeutic potential of Pic in type 1 diabetes and the anti-diabetic effects of Pic may be associated with its activities to suppress oxidative stress,inflammation,and ER stress.展开更多
Nonalcoholic fatty liver disease(NAFLD)represents a huge threat to public health of the whole world.Around 25%of NAFLD patients will progress to nonalcoholic steatohepatitis(NASH),which has been predicted to be the ma...Nonalcoholic fatty liver disease(NAFLD)represents a huge threat to public health of the whole world.Around 25%of NAFLD patients will progress to nonalcoholic steatohepatitis(NASH),which has been predicted to be the main reason for liver transplantation in the United States in 2020.Extensive effort has been devoted to investigating the underlying molecular mechanisms of NASH pathogenesis and developing new promising treatments.Recent studies have demonstrated that pyroptosis,an inflammatory programmed cell death mediated by inflammasome and gasdermin-D(GSDMD),is involved in the development and progression of NASH.This review aims to summarize the recent findings regarding the role of pyroptosis and related molecules in the pathogenesis of NASH.展开更多
基金the National Natural Science Foundation of China under Grant 21677076 and 31970897 to DWOutstanding Youth Foundation of Jiangsu Province(BK20190093)to DWQing Lan Project of Jiangsu Province to DW,the Fundamental Research Funds for the Central Universities No.30919011102 to DW,the Innovative and Entrepreneurial Talent Cultivation(Shuangchuang)Program of Jiangsu Province to DW.
文摘As a natural analog of resveratrol,piceatannol(Pic)exhibits good antioxidant and anti-inflammatory activities in different disease models.However,the role of Pic in type 1 diabetes mousemodel has not been reported yet.In this study,we investigated the in vivo effect of Pic in streptozotocin(STZ)-induced type 1 diabetic mice.Mice were injected with STZ to establish the type 1 diabetesmellitus(T1DM)model.After stable hyperglycemia was achieved,mice were then orally treated with Pic(40 mg/kg b.w.,i.g.)for 30 days.The results indicated that Pic supplementation efficiently alleviated the typical symptoms associated with T1DM,including body weight loss,polydipsia,hyperglycemia,and hypoinsulinemia.Pic treatment also improved the glucose tolerance of STZ-induced diabetic mice.In addition,Pic supplementation markedly decreased the expression of pro-inflammatory molecules TNF-αand IL-6,the expression of endoplasmic reticulum(ER)stress markers GRP78 and CHOP,and the level of oxidative stress in T1DM mice.Moreover,Pic administration also partly reversed the metabolic profiles of STZ-treated mice as detected by 1H Nuclear Magnetic Resonance(NMR)-based metabolomics.Our study suggested that the therapeutic potential of Pic in type 1 diabetes and the anti-diabetic effects of Pic may be associated with its activities to suppress oxidative stress,inflammation,and ER stress.
基金the National Natural Science Foundation of China under Grant 31970897Outstanding Youth Foundation of Jiangsu Province(BK20190069)Qing Lan Project of Jiangsu Province,and the Fundamental Research Funds for the Central Universities No.30919011102.
文摘Nonalcoholic fatty liver disease(NAFLD)represents a huge threat to public health of the whole world.Around 25%of NAFLD patients will progress to nonalcoholic steatohepatitis(NASH),which has been predicted to be the main reason for liver transplantation in the United States in 2020.Extensive effort has been devoted to investigating the underlying molecular mechanisms of NASH pathogenesis and developing new promising treatments.Recent studies have demonstrated that pyroptosis,an inflammatory programmed cell death mediated by inflammasome and gasdermin-D(GSDMD),is involved in the development and progression of NASH.This review aims to summarize the recent findings regarding the role of pyroptosis and related molecules in the pathogenesis of NASH.
