Blockchain-Based Data Acquisition with Privacy Protection in UAV Cluster Network

The unmanned aerial vehicle(UAV)self-organizing network is composed of multiple UAVs with autonomous capabilities according to a certain structure and scale,which can quickly and accurately complete complex tasks such as path planning,situational awareness,and information transmission.Due to the openness of the network,the UAV cluster is more vulnerable to passive eavesdropping,active interference,and other attacks,which makes the system face serious security threats.This paper proposes a Blockchain-Based Data Acquisition(BDA)scheme with privacy protection to address the data privacy and identity authentication problems in the UAV-assisted data acquisition scenario.Each UAV cluster has an aggregate unmanned aerial vehicle(AGV)that can batch-verify the acquisition reports within its administrative domain.After successful verification,AGV adds its signcrypted ciphertext to the aggregation and uploads it to the blockchain for storage.There are two chains in the blockchain that store the public key information of registered entities and the aggregated reports,respectively.The security analysis shows that theBDAconstruction can protect the privacy and authenticity of acquisition data,and effectively resist a malicious key generation center and the public-key substitution attack.It also provides unforgeability to acquisition reports under the Elliptic Curve Discrete Logarithm Problem(ECDLP)assumption.The performance analysis demonstrates that compared with other schemes,the proposed BDA construction has lower computational complexity and is more suitable for the UAV cluster network with limited computing power and storage capacity.

A biomimetic nanoplatform for customized photothermal therapy of HNSCC evaluated on patient-derived xenograft models

Cancer cell membrane(CCM)derived nanotechnology functionalizes nanoparticles(NPs)to recognize homologous cells,exhibiting translational potential in accurate tumor therapy.However,these nanoplatforms are majorly generated from fixed cell lines and are typically evaluated in cell line-derived subcutaneous-xenografts(CDX),ignoring the tumor heterogeneity and differentiation from inter-and intra-individuals and microenvironments between heterotopic-and orthotopic-tumors,limiting the therapeutic efficiency of such nanoplatforms.Herein,various biomimetic nanoplatforms(CCM-modified gold@Carbon,i.e.,Au@C-CCM)were fabricated by coating CCMs of head and neck squamous cell carcinoma(HNSCC)cell lines and patient-derived cells on the surface of Au@C NP.The generated Au@C-CCMs were evaluated on corresponding CDX,tongue orthotopic xenograft(TOX),immunecompetent primary and distant tumor models,and patient-derived xenograft(PDX)models.The Au@C-CCM generates a photothermal conversion efficiency up to 44.2% for primary HNSCC therapy and induced immunotherapy to inhibit metastasis via photothermal therapy-induced immunogenic cell death.The homologous CCM endowed the nanoplatforms with optimal targeting properties for the highest therapeutic efficiency,far above those with mismatched CCMs,resulting in distinct tumor ablation and tumor growth inhibition in all four models.This work reinforces the feasibility of biomimetic NPs combining modular designed CMs and functional cores for customized treatment of HNSCC,can be further extended to other malignant tumors therapy.

“功能主义”和“建构主义”视角下集体记忆与档案价值挖掘和应用研究

集体记忆作为一个跨学科的概念,近年来受到档案学界的广泛关注和研究。文章引入功能主义和建构主义的研究视角,试图探究档案与集体记忆的互动关联。功能主义视角下,档案积极发挥其作为资源、媒介和权力的价值,在集体记忆的形成、保存、传承等过程中发挥着不可替代的重要作用;建构主义视角下,档案工作者和社会公众同为集体记忆的积极建构者,在档案馆所构筑的"记忆之场"中,不断推进集体记忆的运行。

A Distributed Intrusion Detection Model via Nondestructive Partitioning and Balanced Allocation for Big Data

There are two key issues in distributed intrusion detection system,that is,maintaining load balance of system and protecting data integrity.To address these issues,this paper proposes a new distributed intrusion detection model for big data based on nondestructive partitioning and balanced allocation.A data allocation strategy based on capacity and workload is introduced to achieve local load balance,and a dynamic load adjustment strategy is adopted to maintain global load balance of cluster.Moreover,data integrity is protected by using session reassemble and session partitioning.The simulation results show that the new model enjoys favorable advantages such as good load balance,higher detection rate and detection efficiency.

Metabolomic and proteomic responses of Phaeodactylum tricornutum to hypoxia

Diatoms are important contributors to global net primary productivity,and play a crucial role in the biogeochemical cycles of carbon,phosphorus,nitrogen,iron,and silicon.Currently in some regions in the ocean,there’s a trend that carbon content is high while oxygen concentration is low,and the underlying mechanisms of diatoms’response to low oxygen environments are worth investigating.Phaeodactylum tricornutum is a model diatom whose genome has been sequenced;it provides a universal molecular toolbox and a stable transgenic expression system.Therefore,the study of the responses of P.tricornutum to low oxygen has not only fundamental research significance but also important ecologic al significance.In this study,growth rates were determined and proteomic analysis and metabolomic analysis were performed to examine P.tricornutum responses under different oxygen concentrations(2%oxygen concentration for hypoxic condition and 21%oxygen concentration for the normal condition(sterilized air)).Results show that the hypoxic environment inhibited the growth of P.tricornutum.In the hypoxic conditions,P.tricornutum could reset its metabolism pathways,including enhancement in lipid utilization,replenishment of tricarboxylic acid(TCA)cycle through the glyoxylic acid cycle,and down-regulation of photorespiration to reduce energy waste.Additionally,the stress resistance mechanism was activated to facilitate the adaptation to low oxygen conditions.This study helps to reveal the different metabolic changes to hypoxia of diatom from that of higher plants,which might be ascribed to their different habitats and needs further exploration in the future.

CO_(2)LASER PLUS PHOTODYNAMIC THERAPY VERSUS CO_(2)LASER IN THE TREATMENT OF CONDYLOMA ACUMINATUM:A RANDOMIZED COMPARATIVE STUDY

To compare the efficacy and safety of CO_(2)laser plus 5-aminolevulinic acid(ALA)photodynamic therapy(PDT)with CO_(2)laser for the treatment of multiple condyloma acuminatum(CA),120 patients with multiple CA were allocated into two groups—combined group(CO_(2)laser plus ALA-PDT,n=60)and CO_(2)laser group(CO_(2)laser plus placebo-PDT,n=60).After CO_(2)laser,a 20%ALA or a placebo solution was applied to the CA area 3 h before illumination with red light(635 nm,100mW/cm^(2),80 J/cm^(2)).The treatment was repeated seven days after the first treatment if the lesions were not completely resolved.The complete response rate,recurrence rate and adverse effects in the two groups were analyzed.After two treatments,the complete response rates in the CO_(2)laser group and combined group were 100%(509/509)and 100%(507/507)in the CA(p>0:05),respectively.The recurrence rates in the CO_(2)laser group and combined group were 44.9%(229/509)and 10.6%(54/507)in the CA(p<0:05),respectively.The adverse effects in CO_(2)laser group was more than that in combined group.The combined group is a more effective treatment for multiple CA compared with CO_(2)laser group.T/S.Style the highlighted text as abstract.

Achieving Privacy-Preserving Iris Identification Via El Gamal

Currently,many biometric systems maintain the user’s biometrics and templates in plaintext format,which brings great privacy risk to uses’biometric information.Biometrics are unique and almost unchangeable,which means it is a great concern for users on whether their biometric information would be leaked.To address this issue,this paper proposes a confidential comparison algorithm for iris feature vectors with masks,and develops a privacy-preserving iris verification scheme based on the El Gamal encryption scheme.In our scheme,the multiplicative homomorphism of encrypted features is used to compare of iris features and their mask information.Also,this paper improves the Hamming distance of iris features,which makes the similarity matching work better than existing ones.Experimental results confirm the practicality of our proposed schemes in real world applications,that is,for the iris feature vectors and masks of 2048 bits,nearly 12 comparisons can be performed per second.

Preparation and Performance Research of CuInSe₂Materials Applied in Solar Cell

At present, CuInSe2 (referred to as CIS) semiconductor has become one of the hot points in solar cell field at home and abroad for its excellent performances, such as direct bandgap, high light absorption coefficient, high photoelectric conversion efficiency and long-term stability. In this paper, the CIS bulk materials are prepared by the horizontal Bridgman method with double-heat sources, the crystal structure, microstructure morphology and composition of the samples are analyzed in X-ray diffraction instrument (XRD) and scanning electronic microscope (SEM) with Energy Dispersive X-ray Spectrum (EDX), and surface electrical state and electrical properties of the samples are characterized in X-ray photoelectron spectroscopy (XPS) and four point resistivity test system. The results show that the CIS crystal was grown, and that the conductive performance of the samples is good which display the characteristics of p-type semiconductor. Furthermore, a thin film CIS sample was obtained by argon ion-beam scanning bombardment, and it has high solar energy absorptivity and the bandgap of 0.99 eV analyzed in Ultraviolet-visible Spectrum that is suitable for solar cell. Keywords:

Wireless Communication Signal Strength Prediction Method Based on the K-nearest Neighbor Algorithm

Existing interference protection systems lack automatic evaluation methods to provide scientific, objective and accurate assessment results. To address this issue, this paper develops a layout scheme by geometrically modeling the actual scene, so that the hand-held full-band spectrum analyzer would be able to collect signal field strength values for indoor complex scenes. An improved prediction algorithm based on the K-nearest neighbor non-parametric kernel regression was proposed to predict the signal field strengths for the whole plane before and after being shield. Then the highest accuracy set of data could be picked out by comparison. The experimental results show that the improved prediction algorithm based on the K-nearest neighbor non-parametric kernel regression can scientifically and objectively predict the indoor complex scenes’ signal strength and evaluate the interference protection with high accuracy.

A Privacy-Preserving TPA-aided Remote Data Integrity Auditing Scheme in Clouds

The remote data integrity auditing technology can guarantee the integrity of outsourced data in clouds. Users can periodically run an integrity auditing protocol by interacting with cloud server, to verify the latest status of outsourced data. Integrity auditing requires user to take massive time-consuming computations, which would not be affordable by weak devices. In this paper, we propose a privacy-preserving TPA-aided remote data integrity auditing scheme based on Li et al.’s data integrity auditing scheme without bilinear pairings, where a third party auditor (TPA) is employed to perform integrity auditing on outsourced data for users. The privacy of outsourced data can be guaranteed against TPA in the sense that TPA could not infer its contents from the returned proofs in the integrity auditing phase. Our construction is as efficient as Li et al.’s scheme, that is, each procedure takes the same time-consuming operations in both schemes, and our solution does not increase the sizes of processed data, challenge and proof.

Small-molecule agents for cancer immunotherapy

Cancer immunotherapy,exemplified by the remarkable clinical benefits of the immune checkpoint blockade and chimeric antigen receptor T-cell therapy,is revolutionizing cancer therapy.They induce long-term tumor regression and overall survival benefit in many types of cancer.With the advances in our knowledge about the tumor immune microenvironment,remarkable progress has been made in the development of small-molecule drugs for immunotherapy.Small molecules targeting PRR-associated pathways,immune checkpoints,oncogenic signaling,metabolic pathways,cytokine/chemokine signaling,and immune-related kinases have been extensively investigated.Monotherapy of smallmolecule immunotherapeutic drugs and their combinations with other antitumor modalities are under active clinical investigations to overcome immune tolerance and circumvent immune checkpoint inhibitor resistance.Here,we review the latest development of small-molecule agents for cancer immunotherapy by targeting defined pathways and highlighting their progress in recent clinical investigations.

13-Valent pneumococcal conjugate vaccines vaccination innovative strategy in Weifang City,China:a case study

The World Health Organization(WHO)prioritizes pneumococcal disease as a vaccine-preventable disease and recommends the inclusion of pneumococcal conjugate vaccines(PCV)in national immunization programs worldwide.However,PCV is not included in the National Immunization Program in China and has low vaccination coverage due to its high cost.To address this,Weifang City implemented an innovative strategy for a 13-valent PCV(PCV13)on June 1,2021.This strategy aimed to provide one dose of PCV13 free of charge for children aged 6 months to 2 years in registered households and to adopt a commercial insurance model with one dose of PCV13 free of charge in 2023 for children over 2 years old.The Health Commission of Weifang and other departments conducted a comprehensive investigation and considered various factors,such as vaccine efectiveness,safety,accessibility,vaccine price,and immunization schedules,for eligible children(under 5 years old).Stakeholder opinions were also solicited before implementing the policy.The Commission negotiated with various vaccine manufacturers to maximize its negotiating power and reduce vaccine prices.The implementation plan was introduced under the Healthy Weifang Strategy.Following the implementation of this strategy,the full course of vaccination coverage increased signifcantly from 0.67 to 6.59%.However,vaccination coverage is still lower than that in developed countries.Weifang’s PCV13 vaccination innovative strategy is the frst of its kind in Chinese mainland and is an active pilot of non-immunization program vaccination strategies.To further promote PCV13 vaccination,Weifang City should continue to implement this strategy and explore appropriate fnancing channels.Regions with higher levels of economic development can innovate the implementation of vaccine programs,broaden fnancing channels,improve accessibility to vaccination services,and advocate for more localities to incorporate PCV13 into locally expanded immunization programs or people-benefting projects.A monitoring and evaluation system should also be established to evaluate implementation efects.

tsrCert:Traceable Self-Randomization Certificate and Its Application to Blockchain Supervision

Traditional public key infrastructure(PKI)only provides authentication for network communication,and the standard X.509 certificate used in this architecture reveals the user’s identity.This lack of privacy protection no longer satisfies the increasing demands for personal privacy.Though an optimized anonymous PKI certificate realizes anonymity,it has the potential to be abused due to the lack of identity tracking.Therefore,maintaining a balance between user anonymity and traceability has become an increasing requirement for current PKI.This paper introduces a novel traceable self-randomization certificate authentication scheme based on PKI architecture that achieves both anonymity and traceability.We propose a traceable self-randomization certificate authentication scheme based on the short randomizable signature.Specifically,certificate users can randomize the initial certificate and public key into multiple anonymous certificates and public keys by themselves under the premise of traceability,which possesses lower computational complexity and fewer interactive operations.Users can exhibit different attributes of themselves in different scenarios,randomizing the attributes that do not necessarily need to be displayed.Through security and performance analysis,we demonstrate the suitability of the improved PKI architecture for practical applications.Additionally,we provide an application of the proposed scheme to the permissioned blockchain for supervision.

温带草原生态系统土壤原核生物特征对自然水分梯度的响应

土壤水分是影响生态系统功能的重要因素,其不仅可以维持微生物的活性,还可以通过改变植被多样性,控制土壤养分的扩散和运输,最终改变微生物群落。为探索土壤含水量对土壤原核生物群落的影响,本研究在中国内蒙古呼伦湖南岸的草原生态系统中建立了一个覆盖自然土壤水分梯度的研究区域,并将其细分为高含水量(4.80%±1.18%)、中含水量(2.17%±0.09%)和低含水量(1.85%±0.14%)三个梯度。环境因子是通过实地调查和实验室分析获得的。土壤原核生物是通过高通量测序技术测定的。植被特征和土壤理化性质对原核生物丰富度多样性有显著影响,其中土壤含水量是最重要的影响因素。在中含水量梯度中,差异原核生物的数量最少,且门水平原核微生物的多样性和相对丰度最高。这表明中含水量梯度下的原核生物群落的内在变异较小,整体活性较高。此外,高含水量和低含水量梯度的原核生物多样性和门水平相对丰度较低。表型预测结果表明,这两组条件下的原核微生物群落具有更强的耐受性。总之,原核生物群落对呼伦湖南岸草地生态系统的自然水分梯度有明显响应,土壤水分过高或过低都会增加原核生物的抗逆性。

Factors Associated with PCV13 Vaccine Hesitancy in Parents under an Innovative Immunization Strategy:a Cross-Sectional Study—Weifang City,Shandong Province,China,2021

Summary What is already known on this topic?Pneumococcal diseases(PDs)are serious threats to child health.Although vaccination is one of the most effective ways to prevent these diseases,the pneumococcal vaccination coverage rate is still relatively low in China.What is added by this report?This study investigated the factors associated with 13-valent pneumococcal conjugate vaccine(PCV13)vaccine hesitancy in parents under an innovative immunization strategy.

大气颗粒物中棕色碳的化学组成、来源和生成机制

大气颗粒物中棕色碳(BrC)在近紫外波段具有强吸光性,并因其显著的气候效应被广泛关注。BrC组成、来源、演变和光学性质的不确定性是造成气候模型估算气溶胶辐射强迫不确定性的重要因素。本文综述了大气颗粒物中BrC的化学组成、来源和生成机制,聚焦分子水平上BrC组成、二次生成机制和吸光间的关联。大气颗粒物中BrC的主要类别包括有机溶剂(甲醇)提取的碳质组分、水溶性有机碳及类腐殖质;分子水平上,硝基芳香烃和含氮杂环有机物是BrC的主要发色团。BrC的来源包括生物质等不完全燃烧一次排放和挥发性有机物氧化二次生成;二次生成途径主要包括人为源芳香烃氧化生成硝基芳香烃等含氮组分、羰基化合物与铵/胺反应生成含氮杂环组分或低聚物。前体物和反应条件影响二次生成BrC的组成和吸光性质;BrC在大气传输过程中还会发生"光漂白"现象。在分子水平上识别和阐明BrC的发色团、二次生成机制及其演变过程是未来该领域的重点研究方向。

珠江河口区大型底栖动物群落结构

河口区大型底栖动物具有的重要群落特征往往可以反映群落所经历的环境污染。为更好地了解珠江河口区大型底栖动物群落结构,作者于2014年11月至2015年8月进行了4个季度的大型底栖动物调查,并利用PRIMER 6.0软件进行群落生物多样性指数计算、群落等级聚类(Cluster)和非度量多维标度排序(nMDS)分析。研究结果显示:珠江河口区共获得大型底栖动物52种,优势种包括光滑河篮蛤(Potamocorbulalaevis)、中国绿螂(Glaucomya chinensis)、焦河篮蛤(Potamocorbulaustulata)和羽须鳃沙蚕(Dendronerispinnaticirrus)。大型底栖动物年平均密度为269.3 ind./m^2,年平均生物量为129.61g/m^2。12个站次的丰富度指数(D)、均匀度指数(J’)和Shannon-Wiener多样性指数(H’)平均值分别为1.81±1.38、0.50±0.27和1.60±1.13。该结果显示除P01断面的秋季和冬季环境质量为优良外,其他站位在不同季度都显示出轻度到重度的污染。Cluster聚类分析和n MDS标序结果表明, P01断面与P02和P03断面群落相似度较低,与断面地理分布情况一致;P02断面和P03断面存在交叉聚集,群落相似度较高。结合环境因子结果可知,沉积物理化因子与群落分布特征相关性较大,其中最能解释珠江河口区群落多样性分布特征的环境因子为盐度和pH值。

《名古屋议定书》背景下我国传统知识的保护:以德昂族酸茶为例

中国于2016年9月6日成为《名古屋议定书》缔约方,意味着遗传资源及相关传统知识的保护以及获取与惠益分享制度,在国际和国内层面已经步入履行阶段。传统知识的防御性保护是防范生物剽窃,建设性保护是促进惠益分享。本研究通过多年的实地调研发现,德昂族酸茶作为一类与遗传资源相关的传统知识,在原持有方不知情同意的情况下,被某利用方申请了专利,构成了生物剽窃。本研究指出,传统知识防御性保护可考虑修订国内专利法,将传统知识强制性来源披露要求纳入其中,进而防范生物剽窃。为促进传统知识的持有方分享应得惠益和可持续利用,本研究建议依据《名古屋议定书》精神,通过立法制定特殊制度,创造性地发展出可行的惠益分享制度,区分不同的传统知识主体资格,以事先知情同意程序和共同商定条件为途径,以补偿责任或知识共享许可协议为手段,来实现《生物多样性公约》的保护与可持续利用两大目标,方能达成传统知识的建设性保护。

Catalytic fast pyrolysis of Kraft lignin with HZSM-5 zeolite for producing aromatic hydrocarbons

Catalytic fast pyrolysis （CFP） of Kraft lignins with HZSM-5 zeolite for producing aromatics was investigated using analytical pyrolysis methods. Two Kraft lignins were fast pyrolyzed in the absence and presence of HZSM-5 in a Curie-point pyrolyzer. Without the catalyst, fast pyrolysis of lignin predominantly produced phenols and guaiacols that were derived from the subunits of lignin. However, the presence of HZSM-5 changed the product distribution dramatically. As the SiO2/ A1203 ratio of HZSM-5 decreased from 200 to 25 and the catalyst-to-lignin ratio increased from 1 to 20, the lignin- derived oxygenates progressively decreased to trace and the aromatics increased substantially. The aromatic yield increased considerably as the pyrolysis temperature increased from 500~C to 650~C, but then decreased with yet further increase of pyrolysis temperature. Under optimal reaction conditions, the aromatic yields were 2.0 wt.% and 5.2 wt.% for the two lignins that had effective hydrogen indexes of 0.08 and 0.35.

森林生态系统细根周转规律及影响因素

根系周转是陆地生态系统碳循环的关键过程,对研究土壤碳库变化及全球气候变化均具有重要意义。然而由于根系周转率的测量计算方法较多,不同方法得出的结果差异较大,且目前对全球区域尺度上森林生态系统根系周转的研究还不够充分,使得全球森林生态系统根系周转变化规律仍不清楚。该研究通过收集文献数据并统一周转率计算方法,对全球5种森林类型的细根周转空间格局进行整合,同时结合土壤理化性质和气候数据,得出影响森林生态系统细根周转的因子。结果表明,不同森林类型细根周转率存在显著差异,且随着纬度的升高逐渐降低;森林生态系统细根周转率与年平均温度和年平均降水量呈正相关;森林生态系统细根周转率与土壤有机碳含量呈正相关但与土壤pH值呈负相关。该研究为揭示森林生态系统细根周转规律及机制提供了科学依据。