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Single-cell detection by enhancement of fluorescence in waveguides for cancer diagnosis and therapy 被引量:1
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作者 HAILANG DAI HONGRUI SHAN +4 位作者 ZHANGCHI SUN DAOPENG DAI yuxi shang ZHUANGQI CAO XIANFENG CHEN 《Photonics Research》 SCIE EI CAS CSCD 2021年第12期2381-2387,共7页
Cancer is one of the most common diseases to threaten human health.If individuals are diagnosed with malignant tumors via a single cell,medical workers are greatly advantageous to early diagnose and intervene in malig... Cancer is one of the most common diseases to threaten human health.If individuals are diagnosed with malignant tumors via a single cell,medical workers are greatly advantageous to early diagnose and intervene in malignant tumors therapy.In this paper,we propose a fluorescence detection map to rapidly distinguish whether the chromosomes of a cell are normal or abnormal by detecting the fluorescent intensity of a single cell.Herein,we draw a map from a single cell with an abnormal number of chromosomes that is monitored in real time.Moreover,this way offers precise and prompt detection of the surviving of cancer cells at or near the site of the tumor after treatments for cancer,which can achieve personalized cancer diagnosis and therapy.Therefore,cancer recurrences and metastasis can be effectively identified,utilizing this ultrasensitive detection method of an abnormal chromosome number. 展开更多
关键词 diagnosis utilizing PROMPT
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Secondary structure changes of ox-LDL by photoirradiation in an optofluidic resonator
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作者 yuxi shang Hailang Dai +4 位作者 Daopeng qai jinmao Gu Meng Zhang Qiheng Wei Xianfeng Chen 《Chinese Optics Letters》 SCIE EI CAS CSCD 2022年第3期89-94,共6页
Atherosclerotic cardio-cerebral vascular disease is the most common disease that threatens human health.Many researches indicated that oxidatively modified low-density lipoprotein[ox-LDL]is a key pathogenic factor of ... Atherosclerotic cardio-cerebral vascular disease is the most common disease that threatens human health.Many researches indicated that oxidatively modified low-density lipoprotein[ox-LDL]is a key pathogenic factor of atherosclero-sis.Here,we report the change of the secondary structure of ox-LDL caused by photoirradiation in an optofluidic resonator.The content ratios of amphipathic o-helices and β-sheets of ox-LDL are changed under laser beam ilumination,resulting in an increasing binding rate of ox-LDL and ox-LDL antibodies.Our findings may provide a potential way for clinical athero-sclerosis treatment and prompt recovery rate of atherosclerotic cardio-cerebral vascular disease by optical technology and immunotherapy. 展开更多
关键词 ATHEROSCLEROSIS OX-LDL optofluidic resonator PHOTOIRRADIATION
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