Cancer is one of the most common diseases to threaten human health.If individuals are diagnosed with malignant tumors via a single cell,medical workers are greatly advantageous to early diagnose and intervene in malig...Cancer is one of the most common diseases to threaten human health.If individuals are diagnosed with malignant tumors via a single cell,medical workers are greatly advantageous to early diagnose and intervene in malignant tumors therapy.In this paper,we propose a fluorescence detection map to rapidly distinguish whether the chromosomes of a cell are normal or abnormal by detecting the fluorescent intensity of a single cell.Herein,we draw a map from a single cell with an abnormal number of chromosomes that is monitored in real time.Moreover,this way offers precise and prompt detection of the surviving of cancer cells at or near the site of the tumor after treatments for cancer,which can achieve personalized cancer diagnosis and therapy.Therefore,cancer recurrences and metastasis can be effectively identified,utilizing this ultrasensitive detection method of an abnormal chromosome number.展开更多
Atherosclerotic cardio-cerebral vascular disease is the most common disease that threatens human health.Many researches indicated that oxidatively modified low-density lipoprotein[ox-LDL]is a key pathogenic factor of ...Atherosclerotic cardio-cerebral vascular disease is the most common disease that threatens human health.Many researches indicated that oxidatively modified low-density lipoprotein[ox-LDL]is a key pathogenic factor of atherosclero-sis.Here,we report the change of the secondary structure of ox-LDL caused by photoirradiation in an optofluidic resonator.The content ratios of amphipathic o-helices and β-sheets of ox-LDL are changed under laser beam ilumination,resulting in an increasing binding rate of ox-LDL and ox-LDL antibodies.Our findings may provide a potential way for clinical athero-sclerosis treatment and prompt recovery rate of atherosclerotic cardio-cerebral vascular disease by optical technology and immunotherapy.展开更多
基金Shanghai Municipal Science and Technology Major Project(2019SHZDZX01)Foundation for Development of Science and Technology of Shanghai(17JC1400400)+2 种基金fellowship of China Postdoctoral Science Foundation(2020M681275,2021T140452)National Natural Science Foundation of China(11734011,11764020,11974245)National Key R&D Program of China(2017YFA0303701,2018YFA0306301)。
文摘Cancer is one of the most common diseases to threaten human health.If individuals are diagnosed with malignant tumors via a single cell,medical workers are greatly advantageous to early diagnose and intervene in malignant tumors therapy.In this paper,we propose a fluorescence detection map to rapidly distinguish whether the chromosomes of a cell are normal or abnormal by detecting the fluorescent intensity of a single cell.Herein,we draw a map from a single cell with an abnormal number of chromosomes that is monitored in real time.Moreover,this way offers precise and prompt detection of the surviving of cancer cells at or near the site of the tumor after treatments for cancer,which can achieve personalized cancer diagnosis and therapy.Therefore,cancer recurrences and metastasis can be effectively identified,utilizing this ultrasensitive detection method of an abnormal chromosome number.
基金This work was supported by the National Key R&D Program of China(No.2018YFA0306301)the National Natural Science Foundation of China(NSFC)(Nos.11734011,11764020,and 12104298)+1 种基金the China Postdoctoral Science Foundation(Nos.2020M681275 and 2021T140452)the Foundation for Shanghai Municipal Science and Technology Major Project(No.2019SHZDZX01-ZX06).
文摘Atherosclerotic cardio-cerebral vascular disease is the most common disease that threatens human health.Many researches indicated that oxidatively modified low-density lipoprotein[ox-LDL]is a key pathogenic factor of atherosclero-sis.Here,we report the change of the secondary structure of ox-LDL caused by photoirradiation in an optofluidic resonator.The content ratios of amphipathic o-helices and β-sheets of ox-LDL are changed under laser beam ilumination,resulting in an increasing binding rate of ox-LDL and ox-LDL antibodies.Our findings may provide a potential way for clinical athero-sclerosis treatment and prompt recovery rate of atherosclerotic cardio-cerebral vascular disease by optical technology and immunotherapy.