A59-year-old female patient was admitted to our hospital on 9 March 2021,due to recurrent chest pain.She underwent percutaneous coronary intervention,with a focus on the proximal segment of the left anterior descendin...A59-year-old female patient was admitted to our hospital on 9 March 2021,due to recurrent chest pain.She underwent percutaneous coronary intervention,with a focus on the proximal segment of the left anterior descending(LAD)artery,six months prior to admission.The patient had a long-term history of hyperlipidaemia and obstructive sleep apnoea syndrome(OSAS).She also had rheumatoid arthritis and ANCA-associated vasculitis that lasted for more than 10 years and a 9-year history of concomitant hypertension.She was on long-term oral leflunomide and intermittent oral prednisone.The patient underwent a computed tomography angiogram(CTA)six years ago(2015),which showed minor atherosclerotic plaque build-up in the LAD artery and the right coronary artery(RCA)(Figure 1).展开更多
The transient dynamics of anisotropic properties of Ga As was systematically studied by polarization-dependent ultrafast time-resolved transient absorption.Our findings revealed that the anisotropy of reflectivity was...The transient dynamics of anisotropic properties of Ga As was systematically studied by polarization-dependent ultrafast time-resolved transient absorption.Our findings revealed that the anisotropy of reflectivity was enhanced in both pump-induced and probe-induced processes,suggesting an extraordinary resonance absorption of photon-phonon coupling(PPC)with intrinsic anisotropic characteristic in carrier relaxation,regardless of the concrete crystallinity and orientation of GaAs sample.The results,delivering in-depth cognition about the polarization-dependent ultrafast carrier dynamics,also proved the paramount importance of interaction between polarized laser and semiconductor.展开更多
As sessile organisms,plants have evolved numerous strategies to acclimate to changes in environmental temperature.However,the molecular basis of this acclimation remains largely unclear.In this study we identified a t...As sessile organisms,plants have evolved numerous strategies to acclimate to changes in environmental temperature.However,the molecular basis of this acclimation remains largely unclear.In this study we identified a tRNAHis guanylyltransferase,AET1,which contributes to the modification of pre-tRNAH,s and is required for normal growth under high-temperature conditions in rice.Interestingly,AET1 possibly interacts with both RACK1A and elF3h in the endoplasmic reticulum.Notably,AET1 can directly bind to OsARF mRNAs including the uORFs of OsARF19 and OsARF23,indicating that AET1 is associated with translation regulation.Furthermore,polysome profiling assays suggest that the translational status remains unaffected in the aet1 mutant,but that the translational efficiency of OsARF19 and OsARF23 is reduced;moreover,OsARF23 protein levels are obviously decreased in the aet1 mutant under high temperature,implying that AET1 regulates auxin signaling in response to high temperature.Ourfindings provide new insights into the molecular mechanisms whereby AET1 regulates the environmental temperature response in rice by playing a dual role in tRNA modification and translational control.展开更多
Ongoing soil salinization drastically threatens crop growth,development,and yield worldwide.It is therefore crucial that we improve salt tolerance in rice by exploiting natural genetic variation.However,many salt-resp...Ongoing soil salinization drastically threatens crop growth,development,and yield worldwide.It is therefore crucial that we improve salt tolerance in rice by exploiting natural genetic variation.However,many salt-responsive genes confer undesirable phenotypes and therefore cannot be effectively applied to practical agricultural production.In this study,we identified a quantitative trait locus for salt tolerance from the African rice species Oryza glaberrima and named it as Salt Tolerance and Heading Date 1(STH1).We found that STH1 regulates fatty acid metabolic homeostasis,probably by catalyzing the hydrolytic degradation of fatty acids,which contributes to salt tolerance.Meanwhile,we demonstrated that STH1 forms a protein complex with D3 and a vital regulatory factor in salt tolerance,OsHAL3,to regulate the protein abundance of OsHAL3 via the 26S proteasome pathway.Furthermore,we revealed that STH1 also serves as a co-activator with the floral integrator gene Heading date 1 to balance the expression of the florigen gene Heading date 3a under different circumstances,thus coordinating the regulation of salt tolerance and heading date.Notably,the allele of STH1 associated with enhanced salt tolerance and high yield is found in some African rice accessions but barely in Asian cultivars.Introgression of the STH1HP46 allele from African rice into modern rice cultivars is a desirable approach for boosting grain yield under salt stress.Collectively,our discoveries not only provide conceptual advances on the mechanisms of salt tolerance and synergetic regulation between salt tolerance and flowering time but also offer potential strategies to overcome the challenges resulted from increasingly serious soil salinization that many crops are facing.展开更多
基金funded by the Project of Hebei Province Key Research and Development Program(Project:182777166)Lang Fang Science and Technology Research and Development Plan (Project:2 020013106).
文摘A59-year-old female patient was admitted to our hospital on 9 March 2021,due to recurrent chest pain.She underwent percutaneous coronary intervention,with a focus on the proximal segment of the left anterior descending(LAD)artery,six months prior to admission.The patient had a long-term history of hyperlipidaemia and obstructive sleep apnoea syndrome(OSAS).She also had rheumatoid arthritis and ANCA-associated vasculitis that lasted for more than 10 years and a 9-year history of concomitant hypertension.She was on long-term oral leflunomide and intermittent oral prednisone.The patient underwent a computed tomography angiogram(CTA)six years ago(2015),which showed minor atherosclerotic plaque build-up in the LAD artery and the right coronary artery(RCA)(Figure 1).
基金supported by the National Natural Science Foundation of China(Grant Nos.51875006 and 51705009)。
文摘The transient dynamics of anisotropic properties of Ga As was systematically studied by polarization-dependent ultrafast time-resolved transient absorption.Our findings revealed that the anisotropy of reflectivity was enhanced in both pump-induced and probe-induced processes,suggesting an extraordinary resonance absorption of photon-phonon coupling(PPC)with intrinsic anisotropic characteristic in carrier relaxation,regardless of the concrete crystallinity and orientation of GaAs sample.The results,delivering in-depth cognition about the polarization-dependent ultrafast carrier dynamics,also proved the paramount importance of interaction between polarized laser and semiconductor.
基金supported by the grants from National Natural Science Foundation of China (31630052,31788103)the Ministry of Science and Technology of China (2016YFD0100902,2016YFD0100604)+2 种基金Chinese Academy of Sciences (QYZDY-SSW-SMC023,XDB27010104)the Shanghai Science and Technology Development (18JC1415000)CASCroucher Funding Scheme for Joint Laboratories,and National Key Laboratory of Plant Molecular Genetics,China.
文摘As sessile organisms,plants have evolved numerous strategies to acclimate to changes in environmental temperature.However,the molecular basis of this acclimation remains largely unclear.In this study we identified a tRNAHis guanylyltransferase,AET1,which contributes to the modification of pre-tRNAH,s and is required for normal growth under high-temperature conditions in rice.Interestingly,AET1 possibly interacts with both RACK1A and elF3h in the endoplasmic reticulum.Notably,AET1 can directly bind to OsARF mRNAs including the uORFs of OsARF19 and OsARF23,indicating that AET1 is associated with translation regulation.Furthermore,polysome profiling assays suggest that the translational status remains unaffected in the aet1 mutant,but that the translational efficiency of OsARF19 and OsARF23 is reduced;moreover,OsARF23 protein levels are obviously decreased in the aet1 mutant under high temperature,implying that AET1 regulates auxin signaling in response to high temperature.Ourfindings provide new insights into the molecular mechanisms whereby AET1 regulates the environmental temperature response in rice by playing a dual role in tRNA modification and translational control.
基金This work was supported by thegrants from Laboratory of Lingnan Modern Agriculture Project(NT2021002)National Natural Science Foundation of China(31788103)+1 种基金Chinese Academyof Sciences(XDB27010104,QYZDY-SSW-SMC023,159231KYSB20200008)CAS-Croucher Funding Scheme for Joint Laboratories,and National Key Laboratory of Plant MolecularGenetics。
文摘Ongoing soil salinization drastically threatens crop growth,development,and yield worldwide.It is therefore crucial that we improve salt tolerance in rice by exploiting natural genetic variation.However,many salt-responsive genes confer undesirable phenotypes and therefore cannot be effectively applied to practical agricultural production.In this study,we identified a quantitative trait locus for salt tolerance from the African rice species Oryza glaberrima and named it as Salt Tolerance and Heading Date 1(STH1).We found that STH1 regulates fatty acid metabolic homeostasis,probably by catalyzing the hydrolytic degradation of fatty acids,which contributes to salt tolerance.Meanwhile,we demonstrated that STH1 forms a protein complex with D3 and a vital regulatory factor in salt tolerance,OsHAL3,to regulate the protein abundance of OsHAL3 via the 26S proteasome pathway.Furthermore,we revealed that STH1 also serves as a co-activator with the floral integrator gene Heading date 1 to balance the expression of the florigen gene Heading date 3a under different circumstances,thus coordinating the regulation of salt tolerance and heading date.Notably,the allele of STH1 associated with enhanced salt tolerance and high yield is found in some African rice accessions but barely in Asian cultivars.Introgression of the STH1HP46 allele from African rice into modern rice cultivars is a desirable approach for boosting grain yield under salt stress.Collectively,our discoveries not only provide conceptual advances on the mechanisms of salt tolerance and synergetic regulation between salt tolerance and flowering time but also offer potential strategies to overcome the challenges resulted from increasingly serious soil salinization that many crops are facing.