Objective: To evaluate whether the combination of Uremic clearance granule with Alprostadil is superior to Alprostadil alone for CRF. Methods: Relevant RCTs were searched through March 2019. Data were analyzed by Stat...Objective: To evaluate whether the combination of Uremic clearance granule with Alprostadil is superior to Alprostadil alone for CRF. Methods: Relevant RCTs were searched through March 2019. Data were analyzed by Stata 15.0. Results: Nine articles involving 726 patients were enrolled in this study. Meta-analysis showed that the total effective rate [OR = 3.68 (2.44, 5.55), P < 0.001], Scr [SMD =-2.34 (-3.49,-1.19), P < 0.001], BUN [SMD =-1.80 (-2.73,-0.87), P < 0.001], Ccr [SMD = 0.71 (0.44, 0.97), P < 0.001] were better in the experimental group. But there were no significant difference in UA, CysC, 24h-Upro and incidence of adverse reactions (all P > 0.05) between two groups. No serious adverse reactions were found. Conclusions: The effect of the integrated medicine on CRF was better than Alprostadil alone. Uremic clearance granule is safe and has no obvious adverse reactions.展开更多
The generalized-stacking-fault energies are calculated to illustrate the dissociation of〈c＋a〉dislocation on pyramidal I plane in magnesium.The c surfaces of {1011} plane and its adjacent planes {3034} and {3032} ar...The generalized-stacking-fault energies are calculated to illustrate the dissociation of〈c＋a〉dislocation on pyramidal I plane in magnesium.The c surfaces of {1011} plane and its adjacent planes {3034} and {3032} are presented using Liu embedded-atom-method potential method,and one possible dissociation path of 1/3{1123} dislocation on {1011} plane with minimum energy is predicted.Meanwhile,another two reasonable dissociation paths of 1/3{1123} dislocation successively on {3034} and {3032} planes are also proposed.Moreover,based on molecular dynamics simulations of magnesium single crystals under c-axis compression,the possible slip path is further examined and discussed.展开更多
Molecular dynamics simulation is employed to study the tension and compression deformation behaviors of magnesium single crystals with different orientations.The angle between the loading axis and the basal direction ...Molecular dynamics simulation is employed to study the tension and compression deformation behaviors of magnesium single crystals with different orientations.The angle between the loading axis and the basal direction ranges from 0° to 90°.The simulation results show that the initial defects usually nucleate at free surfaces,but the initial plastic deformation and the subsequent microstructural evolutions are various due to different loading directions.The tension simulations exhibit the deformation mechanisms of twinning,slip,crystallographic reorientation and basal/prismatic transformation.The twinning,crystallographic reorientation and basal/prismatic transformation can only appear in the crystal model loaded along or near the a-axis or c-axis.For the compression simulations,the basal,prismatic and pyramidal slips are responsible for the initial plasticity,and no twinning is observed.Moreover,the plastic deformation models affect the yield strengths for the samples with different orientations.The maximum yield stresses for the samples loaded along the c-axis or a-axis are much higher than those loaded in other directions.展开更多
文摘Objective: To evaluate whether the combination of Uremic clearance granule with Alprostadil is superior to Alprostadil alone for CRF. Methods: Relevant RCTs were searched through March 2019. Data were analyzed by Stata 15.0. Results: Nine articles involving 726 patients were enrolled in this study. Meta-analysis showed that the total effective rate [OR = 3.68 (2.44, 5.55), P < 0.001], Scr [SMD =-2.34 (-3.49,-1.19), P < 0.001], BUN [SMD =-1.80 (-2.73,-0.87), P < 0.001], Ccr [SMD = 0.71 (0.44, 0.97), P < 0.001] were better in the experimental group. But there were no significant difference in UA, CysC, 24h-Upro and incidence of adverse reactions (all P > 0.05) between two groups. No serious adverse reactions were found. Conclusions: The effect of the integrated medicine on CRF was better than Alprostadil alone. Uremic clearance granule is safe and has no obvious adverse reactions.
基金supported by the Fundamental Research Funds for the Central Universities of China (No.2014YJS092)the National Natural Science Foundation of China (No.11372032)
文摘The generalized-stacking-fault energies are calculated to illustrate the dissociation of〈c＋a〉dislocation on pyramidal I plane in magnesium.The c surfaces of {1011} plane and its adjacent planes {3034} and {3032} are presented using Liu embedded-atom-method potential method,and one possible dissociation path of 1/3{1123} dislocation on {1011} plane with minimum energy is predicted.Meanwhile,another two reasonable dissociation paths of 1/3{1123} dislocation successively on {3034} and {3032} planes are also proposed.Moreover,based on molecular dynamics simulations of magnesium single crystals under c-axis compression,the possible slip path is further examined and discussed.
基金supported by the National Natural Science Foundation of China(No.11372032)The Open Project of Key Laboratory of Computational Physics in China
文摘Molecular dynamics simulation is employed to study the tension and compression deformation behaviors of magnesium single crystals with different orientations.The angle between the loading axis and the basal direction ranges from 0° to 90°.The simulation results show that the initial defects usually nucleate at free surfaces,but the initial plastic deformation and the subsequent microstructural evolutions are various due to different loading directions.The tension simulations exhibit the deformation mechanisms of twinning,slip,crystallographic reorientation and basal/prismatic transformation.The twinning,crystallographic reorientation and basal/prismatic transformation can only appear in the crystal model loaded along or near the a-axis or c-axis.For the compression simulations,the basal,prismatic and pyramidal slips are responsible for the initial plasticity,and no twinning is observed.Moreover,the plastic deformation models affect the yield strengths for the samples with different orientations.The maximum yield stresses for the samples loaded along the c-axis or a-axis are much higher than those loaded in other directions.
