Objective:To study the effects of dietary fiber in enteral nutrition on inflammatory reaction, immune response and intestinal mucosal barrier in patients with severe acute pancreatitis. Methods: The patients with seve...Objective:To study the effects of dietary fiber in enteral nutrition on inflammatory reaction, immune response and intestinal mucosal barrier in patients with severe acute pancreatitis. Methods: The patients with severe acute pancreatitis treated in our hospital between February 2015 and February 2018 were selected and randomly divided into two groups. The observation group received basic treatment combined with enteral nutrition containing dietary fiber, and the control group received basic treatment combined with conventional enteral nutrition. The contents of inflammatory cytokines and intestinal mucosal barrier markers in serum, the number of immune cells in peripheral blood as well as the number of intestinal flora in feces were measured respectively before treatment and 7 d after treatment.Results: Interleukin-8 (IL-8), monocyte chemoattractant protein (MCP-1), soluble intercellular adhesion molecule-1 (sICAM-1), soluble triggering receptor expressed on myeloid cells-1 (sTREM1), endotoxin, D-lactic acid and diamine oxidase (DAO) contents in serum, the number of CD8+T cells in peripheral blood as well as the number of enterococcus and enterobacterium in feces of both groups were significantly lower while the number of CD3+T cells, CD4+T cells, CD19+B cells and CD16+CD56+NK cells in peripheral blood as well as the number of bifidobacteria and lactobacillus in feces were significantly higher after treatment, and IL-8, MCP-1, sICAM-1, sTREM1, endotoxin, D-lactic acid and DAO contents in serum, the number of CD8+T cells in peripheral blood as well as the number of enterococcus and enterobacterium in feces of observation group after treatment were significantly lower than those of control group while the number of CD3+T cells, CD4+T cells, CD19+B cells and CD16+CD56+NK cells in peripheral blood as well as the number of bifidobacteria and lactobacillus in feces were significantly higher than those of control group.Conclusion: Dietary fiber in enteral nutrition can alleviate inflammatory reaction, improve immune response and correct intestinal mucosal barrier dysfunction in patients with severe acute pancreatitis.展开更多
植物通过凋落叶、根系凋落物和根系分泌物向土壤输入有机碳,显著影响土壤碳储量。然而,高寒灌丛生态系统这3种植物碳输入途径对气候变暖的响应仍不清楚。本文通过为期3年的野外增温实验,研究了青藏高原东部高寒灌丛优势种窄叶鲜卑花(Sib...植物通过凋落叶、根系凋落物和根系分泌物向土壤输入有机碳,显著影响土壤碳储量。然而,高寒灌丛生态系统这3种植物碳输入途径对气候变暖的响应仍不清楚。本文通过为期3年的野外增温实验,研究了青藏高原东部高寒灌丛优势种窄叶鲜卑花(Sibiraea angustata)凋落叶、根系凋落物和根系分泌物对土壤碳输入的相对贡献及其对增温的响应。研究结果表明,窄叶鲜卑花通过凋落叶、根系凋落物和根系分泌物向土壤输入有机碳的数量分别为77.45、90.58和26.94 g C m^(-2)。增温分别使凋落叶和根系凋落物有机碳输入轻微增加8.04和11.13 g C m^(-2),同时使根系分泌物有机碳输入显著增加15.40 g C m^(-2)。增温使根系分泌物有机碳输入途径相对贡献显著增加4.6%,分别使凋落叶和根系凋落物有机碳输入途径相对贡献轻微降低了2.5%和2.1%。这些结果表明,在青藏高原高寒灌丛生态系统中,气候变暖主要通过促进根系分泌物输入途径而不是凋落物输入途径来增加植物源土壤有机碳的输入。展开更多
文摘Objective:To study the effects of dietary fiber in enteral nutrition on inflammatory reaction, immune response and intestinal mucosal barrier in patients with severe acute pancreatitis. Methods: The patients with severe acute pancreatitis treated in our hospital between February 2015 and February 2018 were selected and randomly divided into two groups. The observation group received basic treatment combined with enteral nutrition containing dietary fiber, and the control group received basic treatment combined with conventional enteral nutrition. The contents of inflammatory cytokines and intestinal mucosal barrier markers in serum, the number of immune cells in peripheral blood as well as the number of intestinal flora in feces were measured respectively before treatment and 7 d after treatment.Results: Interleukin-8 (IL-8), monocyte chemoattractant protein (MCP-1), soluble intercellular adhesion molecule-1 (sICAM-1), soluble triggering receptor expressed on myeloid cells-1 (sTREM1), endotoxin, D-lactic acid and diamine oxidase (DAO) contents in serum, the number of CD8+T cells in peripheral blood as well as the number of enterococcus and enterobacterium in feces of both groups were significantly lower while the number of CD3+T cells, CD4+T cells, CD19+B cells and CD16+CD56+NK cells in peripheral blood as well as the number of bifidobacteria and lactobacillus in feces were significantly higher after treatment, and IL-8, MCP-1, sICAM-1, sTREM1, endotoxin, D-lactic acid and DAO contents in serum, the number of CD8+T cells in peripheral blood as well as the number of enterococcus and enterobacterium in feces of observation group after treatment were significantly lower than those of control group while the number of CD3+T cells, CD4+T cells, CD19+B cells and CD16+CD56+NK cells in peripheral blood as well as the number of bifidobacteria and lactobacillus in feces were significantly higher than those of control group.Conclusion: Dietary fiber in enteral nutrition can alleviate inflammatory reaction, improve immune response and correct intestinal mucosal barrier dysfunction in patients with severe acute pancreatitis.
基金supported by the Open Project from the Ecological Security and Protection Key Laboratory of Sichuan Province(ESP1904,ESP2102)the Doctoral Scientific Research Foundation of China West Normal University(18Q047)the Scientific Research Innovation Team Project of China West Normal University(CXTD2020-4).
文摘植物通过凋落叶、根系凋落物和根系分泌物向土壤输入有机碳,显著影响土壤碳储量。然而,高寒灌丛生态系统这3种植物碳输入途径对气候变暖的响应仍不清楚。本文通过为期3年的野外增温实验,研究了青藏高原东部高寒灌丛优势种窄叶鲜卑花(Sibiraea angustata)凋落叶、根系凋落物和根系分泌物对土壤碳输入的相对贡献及其对增温的响应。研究结果表明,窄叶鲜卑花通过凋落叶、根系凋落物和根系分泌物向土壤输入有机碳的数量分别为77.45、90.58和26.94 g C m^(-2)。增温分别使凋落叶和根系凋落物有机碳输入轻微增加8.04和11.13 g C m^(-2),同时使根系分泌物有机碳输入显著增加15.40 g C m^(-2)。增温使根系分泌物有机碳输入途径相对贡献显著增加4.6%,分别使凋落叶和根系凋落物有机碳输入途径相对贡献轻微降低了2.5%和2.1%。这些结果表明,在青藏高原高寒灌丛生态系统中,气候变暖主要通过促进根系分泌物输入途径而不是凋落物输入途径来增加植物源土壤有机碳的输入。