Objective:The present study was designed to evaluate the effects of adjuvant chemotherapy(CT)vs.radiotherapy(RT,alone or combined with CT)on the prognosis of patients with high-risk,early-stage(stage I and stage II)en...Objective:The present study was designed to evaluate the effects of adjuvant chemotherapy(CT)vs.radiotherapy(RT,alone or combined with CT)on the prognosis of patients with high-risk,early-stage(stage I and stage II)endometrioid endometrial carcinoma.Methods:This single-center retrospective clinical study was conducted in Union Hospital,Tongji Medical College,Huazhong University of Science and Technology between 2010 and 2019.展开更多
Obesity is defined as abnormal or excessive fat accumulation that may impair health.Obesity is associated with numerous pathological changes including insulin resistance,fatty liver,hyperlipidemias,and other obesity-r...Obesity is defined as abnormal or excessive fat accumulation that may impair health.Obesity is associated with numerous pathological changes including insulin resistance,fatty liver,hyperlipidemias,and other obesity-related diseases.These comorbidities comprise a significant public health threat.Existing anti-obesity drugs have been limited by side effects that include depression,suicidal thoughts,cardiovascular complications and stroke.Acupuncture treatment has been shown to be effective for treating obesity and obesity-related conditions,while avoiding side effects.However,the mechanisms of acupuncture in treating obesity-related diseases,especially its effect on neural circuits,are not well understood.A growing body of research has studied acupuncture’s effects on the endocrine system and other mechanisms related to the regulation of neural circuits.In this article,recent research that was relevant to the use of acupuncture to treat obesity and obesity-related diseases through the neuroendocrine system,as well as some neural circuits involved,was summarized.Based on this,acupuncture’s potential ability to regulate neural circuits and its mechanisms of action in the endocrine system were reviewed,leading to a deeper mechanistic understanding of acupuncture’s effects and providing insight and direction for future research about obesity.展开更多
An approach for distinguishing two types of positional isomers of dimeric shikonin and its analogs was explored with ^(4)JC,H long-range correlation by prolonging the acquisition time at ^(2,3)JC,H values of 2.0 and 8...An approach for distinguishing two types of positional isomers of dimeric shikonin and its analogs was explored with ^(4)JC,H long-range correlation by prolonging the acquisition time at ^(2,3)JC,H values of 2.0 and 8.0Hz.Furthermore,the ^(1)H(proton)nuclear magnetic resonance(NMR)pattern of phenolic hydroxyl protons was developed as a“diagnosis signal”to ascertain the relative location of each side chain in DMSO-d_(6) at sample concentrations of 0.022-0.034 mol/L.The chemical shift differences of 0.6ppm between OH-5' and OH-1 and between OH-8'and OH-4 are assigned to Type A and Type B,respectively.All reported ambiguous structures were corrected by this pattern.Additionally,the steric structures of isolated compounds were elucidated by quantum chemical calculations of electronic circular dichroism(ECD)spectra.展开更多
To investigate the reactivity of homoatomic clusters[E_(9)]^(4-)(E=Si-Pb)and intermetalloid clusters[M@E_(9)]^(q-),the reactions of the Zintl anions[Sn_(9)]^(4-) and[Ni@Sn_(9)]^(4-) with the CdMes_(2)(Mes=Mesitylene)i...To investigate the reactivity of homoatomic clusters[E_(9)]^(4-)(E=Si-Pb)and intermetalloid clusters[M@E_(9)]^(q-),the reactions of the Zintl anions[Sn_(9)]^(4-) and[Ni@Sn_(9)]^(4-) with the CdMes_(2)(Mes=Mesitylene)in the presence of 2.2.2-crypt were carried out.Two new compounds[K(2.2.2-crypt)]_(6)[(Sn_(9))Cd(Sn_(9))]·en(1)and[K(2.2.2-crypt)]_(6)[(Ni@Sn_(9))Cd(Ni@Sn_(9))]·en(2)were afforded.Both 1 and 2 were characterized by single-crystal X-ray diffraction,energy dispersive X-ray(EDX),and electrospray ionization mass spectrometry(ESI-MS),and can be viewed as two[Sn_(9)]^(4-)or[Ni@Sn_(9)]^(4-)subunits bridged by Cd ion in an η^(3):η^(3) coordination mode.Quantum chemical calculations reveal the relationships between the geometries and electronic structures of clusters 2a,[Ni_(3)Ge_(18)]^(4-)and[Cu_(4)@Sn_(18)]^(4-).Further electron localization technique(Ad NDP method)was performed to explain chemical bonding patterns of 1a.展开更多
Arnequinol A(1),featuring an unprecedented 6/6/3 tricyclic carbon skeleton fused with a heptatomic oxo-bridge,together with arnequinone A(2)bearing a highly conjugated methyl-shifting benzogeijerene skeleton,were isol...Arnequinol A(1),featuring an unprecedented 6/6/3 tricyclic carbon skeleton fused with a heptatomic oxo-bridge,together with arnequinone A(2)bearing a highly conjugated methyl-shifting benzogeijerene skeleton,were isolated from Arnebia euchroma.Their structures were elucidated by extensive spectro-scopic methods and quantum chemical calculations of the 13 C nuclear magnetic resonance(NMR)data and electronic circular dichroism(ECD)spectra.The plausible biosynthetic pathways for 1 and 2 were presented.In in vitro test,compound 2 showed potent neuroprotective activity against serum-deprivation induced PC12 cell damage at a concentration of 10μmol/L.展开更多
Four new glycosides including a eudesmane-type sesquiterpenoid（1）, a guaiane-type sesquiterpenoid（2）, and two C_（14）-polyacetylenes（3, 4） were isolated from the rhizomes of Atractylodes lancea. Their structure...Four new glycosides including a eudesmane-type sesquiterpenoid（1）, a guaiane-type sesquiterpenoid（2）, and two C_（14）-polyacetylenes（3, 4） were isolated from the rhizomes of Atractylodes lancea. Their structures were elucidated by means of spectroscopic and spectrometric analyses（UV, IR, 1D and 2D NMR, and HR-ESIMS）. The absolute configurations of their aglycones were established based on the experimental and calculated electronic circular dichroism（ECD）, whereas those of monosaccharide moieties were determined by the GC method after chiral derivatization. Compound 4 showed weak anti-inflammatory effects on the LPS-induced NO production in microglia BV2 cells at a concentration of10μmmolL^（-1）.展开更多
Main observation and conclusion Five novel pterocarpan derivatives(1—5)and three known pterocarpans were isolated from the roots of Sophora flavescens Ait.Their structures were elucidated based on extensive spectrosc...Main observation and conclusion Five novel pterocarpan derivatives(1—5)and three known pterocarpans were isolated from the roots of Sophora flavescens Ait.Their structures were elucidated based on extensive spectroscopic data(UV,IR,1D and 2D NMR,and HR-ESI-MS).Notably,compounds 1—5 were the first reported natural products,which possess unique pterocarpan-glucose-long chain aliphatic acid structures.The kinds of aliphatic acids were determined by comparison with authentic aliphatic acids using HPLC-ELSD analysis after acid hydrolysis.The absolute configurations of 1—5 were confirmed by analysis of their ECD spectra.All compounds were evaluated against lipopolysaccharide(LPS)-induced TNF-αproduction in RAW264.7 cells,and compound 1 showed significant inhibitory activity with inhibition rate of 86.22%,IC_(50)=0.79μmol/L(dexamethasone as positive control,inhibition rate of 71.38%).展开更多
文摘Objective:The present study was designed to evaluate the effects of adjuvant chemotherapy(CT)vs.radiotherapy(RT,alone or combined with CT)on the prognosis of patients with high-risk,early-stage(stage I and stage II)endometrioid endometrial carcinoma.Methods:This single-center retrospective clinical study was conducted in Union Hospital,Tongji Medical College,Huazhong University of Science and Technology between 2010 and 2019.
基金supported by National Natural Science Foundation of China(No.81804180)。
文摘Obesity is defined as abnormal or excessive fat accumulation that may impair health.Obesity is associated with numerous pathological changes including insulin resistance,fatty liver,hyperlipidemias,and other obesity-related diseases.These comorbidities comprise a significant public health threat.Existing anti-obesity drugs have been limited by side effects that include depression,suicidal thoughts,cardiovascular complications and stroke.Acupuncture treatment has been shown to be effective for treating obesity and obesity-related conditions,while avoiding side effects.However,the mechanisms of acupuncture in treating obesity-related diseases,especially its effect on neural circuits,are not well understood.A growing body of research has studied acupuncture’s effects on the endocrine system and other mechanisms related to the regulation of neural circuits.In this article,recent research that was relevant to the use of acupuncture to treat obesity and obesity-related diseases through the neuroendocrine system,as well as some neural circuits involved,was summarized.Based on this,acupuncture’s potential ability to regulate neural circuits and its mechanisms of action in the endocrine system were reviewed,leading to a deeper mechanistic understanding of acupuncture’s effects and providing insight and direction for future research about obesity.
基金funded by the CAMS Innovation Fund for Medical Sciences(CIFMS,No.2021-I2M-1-028).
文摘An approach for distinguishing two types of positional isomers of dimeric shikonin and its analogs was explored with ^(4)JC,H long-range correlation by prolonging the acquisition time at ^(2,3)JC,H values of 2.0 and 8.0Hz.Furthermore,the ^(1)H(proton)nuclear magnetic resonance(NMR)pattern of phenolic hydroxyl protons was developed as a“diagnosis signal”to ascertain the relative location of each side chain in DMSO-d_(6) at sample concentrations of 0.022-0.034 mol/L.The chemical shift differences of 0.6ppm between OH-5' and OH-1 and between OH-8'and OH-4 are assigned to Type A and Type B,respectively.All reported ambiguous structures were corrected by this pattern.Additionally,the steric structures of isolated compounds were elucidated by quantum chemical calculations of electronic circular dichroism(ECD)spectra.
基金supported by the National Natural Science Foundation of China(Nos.92161102 and 21971118)the Natural Science Foundation of Tianjin City(Nos.20JCYBJC01560 and B2021202077)to Z.-M.Sun。
文摘To investigate the reactivity of homoatomic clusters[E_(9)]^(4-)(E=Si-Pb)and intermetalloid clusters[M@E_(9)]^(q-),the reactions of the Zintl anions[Sn_(9)]^(4-) and[Ni@Sn_(9)]^(4-) with the CdMes_(2)(Mes=Mesitylene)in the presence of 2.2.2-crypt were carried out.Two new compounds[K(2.2.2-crypt)]_(6)[(Sn_(9))Cd(Sn_(9))]·en(1)and[K(2.2.2-crypt)]_(6)[(Ni@Sn_(9))Cd(Ni@Sn_(9))]·en(2)were afforded.Both 1 and 2 were characterized by single-crystal X-ray diffraction,energy dispersive X-ray(EDX),and electrospray ionization mass spectrometry(ESI-MS),and can be viewed as two[Sn_(9)]^(4-)or[Ni@Sn_(9)]^(4-)subunits bridged by Cd ion in an η^(3):η^(3) coordination mode.Quantum chemical calculations reveal the relationships between the geometries and electronic structures of clusters 2a,[Ni_(3)Ge_(18)]^(4-)and[Cu_(4)@Sn_(18)]^(4-).Further electron localization technique(Ad NDP method)was performed to explain chemical bonding patterns of 1a.
基金supported by the CAMS Innovation Fund for Medical Sciences(No.2016-I2M-1-010,China).
文摘Arnequinol A(1),featuring an unprecedented 6/6/3 tricyclic carbon skeleton fused with a heptatomic oxo-bridge,together with arnequinone A(2)bearing a highly conjugated methyl-shifting benzogeijerene skeleton,were isolated from Arnebia euchroma.Their structures were elucidated by extensive spectro-scopic methods and quantum chemical calculations of the 13 C nuclear magnetic resonance(NMR)data and electronic circular dichroism(ECD)spectra.The plausible biosynthetic pathways for 1 and 2 were presented.In in vitro test,compound 2 showed potent neuroprotective activity against serum-deprivation induced PC12 cell damage at a concentration of 10μmol/L.
基金funded by the National Science and Technology Project of China(No.2012ZX09301002-001003)
文摘Four new glycosides including a eudesmane-type sesquiterpenoid（1）, a guaiane-type sesquiterpenoid（2）, and two C_（14）-polyacetylenes（3, 4） were isolated from the rhizomes of Atractylodes lancea. Their structures were elucidated by means of spectroscopic and spectrometric analyses（UV, IR, 1D and 2D NMR, and HR-ESIMS）. The absolute configurations of their aglycones were established based on the experimental and calculated electronic circular dichroism（ECD）, whereas those of monosaccharide moieties were determined by the GC method after chiral derivatization. Compound 4 showed weak anti-inflammatory effects on the LPS-induced NO production in microglia BV2 cells at a concentration of10μmmolL^（-1）.
基金supported by the National Natural Science Foundtion of China(No.81973194)CAMS Innovation Fund for Medical Sciences(CIFMS)(2019-12M-1-005).
文摘Main observation and conclusion Five novel pterocarpan derivatives(1—5)and three known pterocarpans were isolated from the roots of Sophora flavescens Ait.Their structures were elucidated based on extensive spectroscopic data(UV,IR,1D and 2D NMR,and HR-ESI-MS).Notably,compounds 1—5 were the first reported natural products,which possess unique pterocarpan-glucose-long chain aliphatic acid structures.The kinds of aliphatic acids were determined by comparison with authentic aliphatic acids using HPLC-ELSD analysis after acid hydrolysis.The absolute configurations of 1—5 were confirmed by analysis of their ECD spectra.All compounds were evaluated against lipopolysaccharide(LPS)-induced TNF-αproduction in RAW264.7 cells,and compound 1 showed significant inhibitory activity with inhibition rate of 86.22%,IC_(50)=0.79μmol/L(dexamethasone as positive control,inhibition rate of 71.38%).
