Melanocortins,including a-melanocyte stimulating hormone(a-MSH),b-MSH,g-MSH,and adrenocorticotropin(ACTH),are ancient peptides highly conserved in vertebrates and exhibit diverse well-established functions,including d...Melanocortins,including a-melanocyte stimulating hormone(a-MSH),b-MSH,g-MSH,and adrenocorticotropin(ACTH),are ancient peptides highly conserved in vertebrates and exhibit diverse well-established functions,including dermal pigmentation,adrenal steroidogenesis and cell proliferation,energy homeostasis,and inflammation.1 Melanocortins exert their diverse functions through five melanocortin receptors(MCRs),MC1R-MC5R,numbered based on the sequence of their cloning.展开更多
基金supported by the National Natural Science Foundation of China(grant no.32271165 to Chao Zhang).
文摘Melanocortins,including a-melanocyte stimulating hormone(a-MSH),b-MSH,g-MSH,and adrenocorticotropin(ACTH),are ancient peptides highly conserved in vertebrates and exhibit diverse well-established functions,including dermal pigmentation,adrenal steroidogenesis and cell proliferation,energy homeostasis,and inflammation.1 Melanocortins exert their diverse functions through five melanocortin receptors(MCRs),MC1R-MC5R,numbered based on the sequence of their cloning.
